Difference in Subcellular Distribution between 45- and 37-kDa Mevalonate Pyrophosphate Decarboxylase in Rat Liver

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概要

• 論文の詳細を見る

• We previously reported that the CP diet(a diet containing 5% cholestyramine and 0.1% pravastatin)-induced new species of 37-kDa mevalonate pyrophosphate decarboxylase(MPD)was characteristically and immunologically very similar to the well-known 45-kDa MPD. In the present study, we found a difference in subcellular distribution between 45- and 37-kDa MPD by cell fractionation and immunoblot analysis. The cytosol fraction contained 45- and 37-kDa MPD. Peroxisomal fraction contained a small amount of 45-kDa MPD, but not 37-kDa MPD. Also, 45-kDa MPD in peroxisome is localized n the matrix. From these data, the difference in subcellular distribution between 45- and 37-kDa MPD may be due to differences in the physiological role of cholesterol biosynthesis in rat liver.

• 社団法人日本薬学会の論文
• 2001-12-01

著者

• Yamori Y

  Institute For World Health Development Mukogawa Women's University

• Yamori Y

  Who Centre For Primary Prevention Of Cardiovascular Diseases Kyoto Jpn

• Yamori Yukio

  福山大学 衛生化学

• Yamori Yukio

  三楽病院

• MICHIHARA Akihiro

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• SAWAMURA Makoto

  Takeda Hospital

• AKASAKI Kenji

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• TSUJI Hiroshi

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• MIURA AYAKO

  WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases

• YAMORI Yukio

  Graduate School of Human and Environmental Studies, Kyoto University

• Sawamura M

  Takeda Hospital

• Sagara Miki

  国立国際医療センター研究所

• Sagara Miki

  Research Institute For Production Development

• Miura Ayako

  京都府立医科大学 法医学

• Yamori Y

  Departments Of Pathology Shimane Medical University

• Yamori Yukio

  Life Science Environmental Conservation And Development

• Akasaki K

  Fac. Of Pharmacy And Pharmaceutical Sciences Fukuyama Univ.

• Akasaki Kenji

  Faculty Of Pharmacy & Pharmaceutical Sciences Of Fukuyama University

• Tsuji H

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Yamori Yukio

  Departments Of Pathology Shimane Medical University

• Yamori Yukio

  Graduate School Of Human And Environmental Studies Kyoto University

• Tsuji Hiroshi

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Akasaki K

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Yamori Yuki

  Departments Of Pediatrics And Pathology Shimane Medical University

• Miura Ayako

  Department Of Environmental Preservation And Development

• Tsuji Hiroshi

  Faculty Of Pharmacy & Pharmaceutical Sciences Of Fukuyama University

• Yamori Yukio

  Graduate School of Human and Environmental Studies

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