Probucol Decreases Mevalonate Pyrophosphate Decarboxylase in the Rat Liver(Biochemistry/Molecular Biology)

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概要

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• It is known that cholesterol biosynthesis in the liver is inhibited by probucol. This inhibition by probucol is caused at least in part by a decrease in 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase activity. In this study, we examined serum cholesterol and the change in the activity or protein level of mevalonate pyrophosphate decarboxylase (MPD), which is involved in cholesterol biosynthesis, in the livers of rats fed probucol. The results indicated that serum cholesterol, MPD activity and MPD protein were decreased by 70, 50 and 60% by probucol, respectively, as compared with those in rats fed normal chow. These data show for the first time that probucol decreases the level of an enzyme involved in cholesterol biosynthesis other than HMG-CoA reductase.

• 社団法人日本薬学会の論文
• 2003-10-01

著者

• Nara Yasuo

  就実大学 薬学部応用薬学

• Yamori Yukio

  WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases

• YAMORI Yukio

  Collaborating Center for Prevention of Cardiovascular Diseases

• Yamori Y

  Institute For World Health Development Mukogawa Women's University

• Yamori Y

  Who Centre For Primary Prevention Of Cardiovascular Diseases Kyoto Jpn

• Yamori Yukio

  就実大学 薬学部応用薬学

• Yamori Yukio

  日本大学 内科2

• Yamori Yukio

  福山大学 衛生化学

• Yamori Yukio

  三楽病院

• MICHIHARA Akihiro

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• SAWAMURA Makoto

  Takeda Hospital

• AKASAKI Kenji

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• TSUJI Hiroshi

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• MIURA AYAKO

  WHO Collaborating Center for Research on Primary Prevention of Cardiovascular Diseases

• Sawamura M

  Takeda Hospital

• Sagara Miki

  国立国際医療センター研究所

• Sagara Miki

  Research Institute For Production Development

• Miura Ayako

  京都府立医科大学 法医学

• Yamori Y

  Departments Of Pathology Shimane Medical University

• Yamori Yukio

  Who Collaborating Center

• Yamori Yukio

  Mukogawa Women's University Institute For World Health Development

• Yamori Yukio

  Life Science Environmental Conservation And Development

• Akasaki K

  Fac. Of Pharmacy And Pharmaceutical Sciences Fukuyama Univ.

• Akasaki Kenji

  Faculty Of Pharmacy & Pharmaceutical Sciences Of Fukuyama University

• Nara Y

  Univ. East Asia Shimonoseki Jpn

• Tsuji H

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Yamori Yukio

  Departments Of Pathology Shimane Medical University

• Yamori Yukio

  Graduate School Of Human And Environmental Studies Kyoto University

• Yamori Yukio

  Graduate School Of Human And Environmental Studies University Of Kyoto

• Tsuji Hiroshi

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Akasaki K

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Yamori Yuki

  Departments Of Pediatrics And Pathology Shimane Medical University

• Miura Ayako

  Department Of Environmental Preservation And Development

• Tsuji Hiroshi

  Faculty Of Pharmacy & Pharmaceutical Sciences Of Fukuyama University

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