BIOCHEMICAL REMODELING OF COLLAGEN IN THE HEART OF SPONTANEOUSLY HYPERTENSIVE RATS : Prominent Increase in Type V Collagen

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• To determine how collagen is remodeled in the heart during the development of cardiac hypertrophy, the collagen concentration and the proportions of types I, III, and V collagen were analyzed in the hearts of 10-, 20-, 32-, and 40-week-old spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. The collagen concentration was calculated after the hydroxyproline content was measured and the proportions of types I, III, and V collagen were determined by non-interrupted SDS-polyacrylamide gel electrophoresis (SDS-PAGE). There was no significant difference between the collagen concentrations in 10-week-old SHR and WKY. At 20 weeks, the collagen concentration in the hearts of the SHR had decreased significantly (p< 0.01) when compared to that in the WKY, at 40 weeks, this concentration in SHR had increased significantly (p<0.05) when compared to that in the WKY. Type V collagen in WKY increased with age and type I collagen in the 20- and 40-week-old WKY de-creased significantly (p<0.05) when compared to that in the 10-week-old WKY. However, the proportion of type I collagen in the 20-week-old WKY did not differ from that of the 40-week-old WKY. There was no significant difference between the proportions of the various types of collagen in 10-week-old SHR and those in age- and sex-matched WKY. However, the proportion of type V collagen in the 20- and 40-week-old SHR was significantly (p<0.01) higher than that in age- and sex-matched WKY. Moreover, the proportion of type I collagen in the 40-week-old SHR was significantly (p<0.01) lower than that in age- and sex-matched WKY. The III/I ratio of the 40-week-old SHR was significantly higher than that of age-matched WKY (p< 0.05). These results show qualitatively and quantitatively that collagen is remodeled as cardiac hypertrophy develops and that there is a prominent increase in type V collagen. This suggests that type V collagen is involved in the pathogenesis of cardiac hypertrophy in SHR.

• 社団法人日本循環器学会の論文
• 1993-05-20

著者

• Yamori Y

  Institute For World Health Development Mukogawa Women's University

• Yamori Y

  Who Centre For Primary Prevention Of Cardiovascular Diseases Kyoto Jpn

• Yamori Yukio

  福山大学 衛生化学

• HONDA MASAAKI

  The 4th Department of Internal Medicine, Shimane Medical University

• GOTO YASUTOSHI

  The 4th Department of Internal Medicine, Shimane Medical University

• KUZUO HIROSHI

  The 4th Department of Internal Medicine, Shimane Medical University

• ISHIKAWA SHIGENORI

  The 4th Department of Internal Medicine, Shimane Medical University

• MORIOKA SHIGEFUMI

  The 4th Department of Internal Medicine, Shimane Medical University

• YAMORI YUKIO

  The 2nd Department of Pathology, Shimane Medical University

• MORIYAMA KATSUTOSHI

  The 4th Department of Internal Medicine, Shimane Medical University

• Yamori Yukio

  Who Collaborating Center

• Honda Masaaki

  The 4th Department Of Internal Medicine Shimane Medical University

• MORIOKA Shigefumi

  Cardiovascular Division, Kobe General Hospital

• Morioka Shigefumi

  Fourth Department Of Internal Medicine Shimane Medical University

• Moriyama Katsutoshi

  The Fourth Department Of Internal Medicine Shimane University

• Moriyama Katsutoshi

  The 4th Department Of Internal Medicine Shimane Medical University

• Ishikawa Shigenori

  The 4th Department Of Internal Medicine Shimane Medical University

• Yamori Yukio

  The 2nd Department Of Pathology Shimane Medical University

• Yamori Yukio

  Departments Of Pathology Shimane Medical University

• Kuzuo Hiroshi

  The 4th Department Of Internal Medicine Shimane Medical University

• Goto Yasutoshi

  The 4th Department Of Internal Medicine Shimane Medical University

• Morioka Shigefumi

  The 4th Department Of Internal Medicine Shimane Medical University

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