THE EFFECTS OF CORONARY REPERFUSION ON SARCOLEMMAL Na^+, K^+-ATPase ACTIVITY IN DOGS
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概要
- 論文の詳細を見る
After the ligation of coronary artery for 1 hour (1-hr group), 2 hours (2-hr group) and 4 hours (4-hr group), we investigated myocardial viability through the alterations in sarcolemmal function with measurements of regional myocardial blood flow (RMBF) and sarcolemmal Na^+, K^+-ATPase (ATPase) activity, comparing these groups with a permanently occluded group (permanent group). RMBF was measured in the ischemic region using hydrogen gas generated by electrolysis. Sarcolemmal membrane debris was prepared from ischemic, marginal and non-ischemic regions of the myocardium 7 days after reperfusion. Seven days after reperfusion, RMBF in 1-hr group recovered to control value. Reduction of RMBF in 2-hr group was significantly less than that of RMBF in parmanent group. There was no significant difference in RMBF between 4-hr group and permanent group. In the ischemic region, reduction of ATPase activity in 1-hr 2-hr group was significantly less than that of enzyme activity in permanent group. There was no difference in enzyme activity between 4-hr agoup and permanent group. In the marginal region, there was no difference in ATPase activity between the reperfusion group and the permanent group. These results show that in 4 hours or more after coronary artery occlusion, little salvage of the myocardium can be induced by acute reperfusion.
- 島根大学の論文
著者
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Nara Yasuo
Department Of Pharmacy School Of Pharmacy Shujitsu University
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Nara Yasuo
就実大学 薬学部応用薬学
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Nara Yasuo
武庫川女子大学
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Yamori Y
Institute For World Health Development Mukogawa Women's University
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Yamori Y
Who Centre For Primary Prevention Of Cardiovascular Diseases Kyoto Jpn
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Yamori Yukio
福山大学 衛生化学
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NAKAZAWA Yoshio
The Fourth Department of Internal Medicine, Shimane Medical University
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ISHIBASHI Yutaka
The Fourth Department of Internal Medicine, Shimane Medical University
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NIHEI Tohyoh
The Fourth Department of Internal Medicine, Shimane Medical University
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MORIOKA Shigefumi
The Fourth Department of Internal Medicine, Shimane Medical University
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MORIYAMA Katsutoshi
The Fourth Department of Internal Medicine, Shimane Medical University
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NARA Yasuo
The Second Department of Pathology, Shimane Medical University
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YAMORI Yukio
The Second Department of Pathology, Shimane Medical University
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Yamori Yukio
Who Collaborating Center
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Morioka Shigefumi
Fourth Department Of Internal Medicine Shimane Medical University
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Nara Y
Univ. East Asia Shimonoseki Jpn
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Moriyama Katsutoshi
The Fourth Department Of Internal Medicine Shimane University
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Nihei Tohyoh
The Fourth Department Of Internal Medicine Shimane Medical University
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Yamori Yukio
Departments Of Pathology Shimane Medical University
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Nakazawa Yoshio
Department Of Cardiology Gotsu Saiseikai General Hospital
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Nagasaka Yukihiro
Cardiovascular Division Department Of Internal Medicine Shimane Medical University
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