Impaired Exercise-Induced Vasodilatation in Chronic Atrial Fibrillation : Role of Endothelium-Derived Nitric Oxide
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概要
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Exercise capacity is often reduced in patients with atrial fibrillation (AF), but very few studies have focused on changes in endothelial function as a potential mechanism for the exercise limitation. The present study used using venous occlusion plethysmography to investigate whether nitric oxide (NO)-mediated vasodilatation is attenuated during exercise in patients with AF by measuring forearm blood flow (FBF) in 10 patients at rest and immediately after 2 levels of rhythmic handgrip exercise, before and after inhibition of NO synthesis with N^G-monomethyl-L-arginine (L-NMMA, 100μmol). The measurements were repeated 1 day after restoration of sinus rhythm by cardioversion. FBF responses to graded doses of acetylcholine (ACh) were also observed before and after cardioversion. Heart rate decreased after cardioversion, but blood pressure did not change. FBF at rest was not affected by cardioversion, but at the highest level of exercise it increased from 28.4±2.3 ml・min^<-1>. dl^<-1> before to 39.4±3.2 ml・min^<-1>・dl^<-1> after cardioversion (p<0.05). L-NMMA significantly decreased FBF at rest (p<0.01) and depressed the increase in FBF response to exercise after (p<0.01), but not before cardioversion. The FBF response to ACh was also accelerated significantly after cardioversion. The present results provide new evidence that NO bioavailability is depressed at rest and during exercise in patients with AF.
- 社団法人日本循環器学会の論文
- 2002-05-20
著者
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Katoh Harumi
倉敷中央病院 循環器内科
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Katoh Harumi
Division Of Cardiology Department Of Internal Medicine Shimane University School Of Medicine
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ISHIBASHI Yutaka
The Fourth Department of Internal Medicine, Shimane Medical University
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Inoue Shin-ichi
The Second Department Of Internal Medicine Matsue City Hospital
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Shimada Toshio
Division Of Cardiobascular Medicine Shimane University Faculty Of Medicine
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Murakami Yo
The Fourth Department of Internal Medicine Shimane Medical University
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Sugamori Takashi
The Fourth Department of Internal Medicine and The First Department of Physiology, Shimane Medical U
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Shimada Toshio
The Fourth Department of Internal Medicine and The First Department of Physiology, Shimane Medical U
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Takahashi Nobuyuki
The Fourth Department of Internal Medicine and The First Department of Physiology, Shimane Medical U
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Sakane Takeshi
The Fourth Department of Internal Medicine and The First Department of Physiology, Shimane Medical U
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Ohata Shuzo
The Fourth Department of Internal Medicine and The First Department of Physiology, Shimane Medical U
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Inoue Shin-ichi
The Fourth Department of Internal Medicine and The First Department of Physiology, Shimane Medical U
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Nakamura Ko
The Fourth Department of Internal Medicine and The First Department of Physiology, Shimane Medical U
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Ohta Yoko
The Fourth Department of Internal Medicine and The First Department of Physiology, Shimane Medical U
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Shimizu Hiromi
The Fourth Department of Internal Medicine and The First Department of Physiology, Shimane Medical U
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Katoh Harumi
The Fourth Department of Internal Medicine and The First Department of Physiology, Shimane Medical U
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Takahashi Nobuyuki
Division Of Cardiovascular Medicine Shimane University Faculty Of Medicine
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Ohta Yoko
Division Of Cardiovascular Medicine Department Of Internal Medicine Shimane University Medical Schoo
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Nakamura Ko
Division Of Cardiovascular Medicine Department Of Internal Medicine Shimane University Medical Schoo
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Ohata Shuzo
Division Of Cardiology Department Of Internal Medicine Shimane University School Of Medicine
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Sakane Takeshi
Division Of Cardiobascular Medicine Shimane University Faculty Of Medicine
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Shimizu Hiromi
Division Of Cardiovascular Medicine Department Of Internal Medicine Shimane University Medical Schoo
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Nakamura Ko
Department Of 2nd. Internal Medicine Matsue City Hospital
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Ishibashi Yutaka
Division Of Cardiobascular Medicine Shimane University Faculty Of Medicine
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