A Multicenter Study Design to Assess the Clinical Usefulness of Semi-Automatic Measurement of Flow-Mediated Vasodilatation of the Brachial Artery

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概要

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• Flow-mediated vasodilatation of the brachial artery (FMD) is a marker which is related to endothelial nitric oxide bioavailability. Commercially available ultrasound machines equipped with online computer-assisted semi-automatic analysis software to measure FMD have recently become available in Japan. These devices enable more convenient examination, enhanced reproducibility of FMD measurement, and a shortened examination time. Using such devices, in the present multicenter prospective study we propose to: 1) establish standardized FMD values and determine the annual rates of FMD change in healthy subjects; 2) confirm the predictive value of FMD for future cardiovascular events in Japanese subjects; 3) evaluate the potential usefulness of a multimarker strategy, including measurements of FMD, pulse-wave velocity (PWV), ankle-brachial pressure index, biochemical markers, and proteomic biomarkers obtained by mass spectroscopic analysis to assess the prognosis of subjects with coronary artery disease; and 4) clarify the usefulness of FMD measurement to predict the rate of progression of carotid atherosclerosis, arterial stiffness and microalbuminuria in subjects with hypertension or diabetes mellitus. In total, we estimate that approximately 4000 Japanese subjects in 3 different study groups will eventually be enrolled in this prospective observational investigation. We anticipate that the present study will provide important evidence for the usefulness of FMD measurement in the risk stratification for cardiovascular disease.

著者

• Yamashina Akira

  Second Department Of Internal Medicine Tokyo Medical University

• Ueda Shinichiro

  Department Of Clinical Pharmacology & Therapeutics

• Koba Shinji

  Department of Medicine, Division of Cardiology, Showa University School of Medicine

• Kohro Takahide

  Department Of Cardiology Tokyo University School Of Medicine

• Ohya Yusuke

  The Third Department of Internal Medicine, University of the Ryukyus

• Ishizu Tomoko

  Cardiovascular Division Graduate School Of Comprehensive Human Sciences University Of Tsukuba

• Koba Shinji

  Department Of Medicine Division Of Cardiology Showa University School Of Medicine

• Kario Kazuomi

  Division Of Cardiology Department Of Internal Medicine Jichi Medical University

• Inoue Teruo

  Department Of Cardiology Koshigaya Hospital Dokkyo University School Of Medicine

• Furumoto Tomoo

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Furukawa Taiji

  Department Of Cardiology Saitama Medical School

• Tomiyama Hirofumi

  Second Department Of Internal Medicine Tokyo Medical University

• Sata Masataka

  Department Of Advanced Clinical Science And Therapeutics Graduate School Of Medicine University Of T

• Maemura Koji

  Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome

• Higashi Yukihito

  Department Of Cardiovascular Physiology And Medicine

• Ishibashi Yutaka

  Division Of Cardiobascular Medicine Shimane University Faculty Of Medicine

• Node Koichi

  Department Of Cardiovascular & Renal Disease Medicine Saga University

• Yamazaki Tsutomu

  Department Of Applied Chemistry Graduate School Of Engineering Tokyo University Of Agriculture And T

• Ito Hiroshi

  Department Neurosurgery Tokyo Medical College

• Ohya Yusuke

  The Third Department Of Internal Medicine Graduate School Of Medicine University Of The Ryukyus

• Takase Bonpei

  Division Of Biomedical Engineering National Defense Medical College Research Institute

• Ueda Shinichiro

  Department of Clinical Pharmacology and Therapeutics, University of the Ryukyus School of Medicine

• TAKEMOTO Yasuhiko

  Department of Graduate Medical Education and General Practice, Osaka City University Graduate School of Medicine

• Watanabe Kentaro

  Department of Applied Physics, Graduate School of Engineering, The University of Tokyo, Bunkyo, Tokyo 113-8656, Japan

• Suzuki Toru

  Department of Applied Electronics, Faculty of Industrial Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan

• Ishizu Tomoko

  Cardiovascular Division, Institute of Clinical Medicine, University of Tsukuba

• Hano Takuzo

  Medical Education and Population-based Medicine, Postgraduate School of Medicine, Wakayama Medical University

• Takemoto Yasuhiko

  Department of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine

• Yamazaki Tsutomu

  Department of Clinical Epidemiology and Systems, Faculty of Medicine, The University of Tokyo

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