Enhanced Expression of the Apoptosis Inducing Ligand TRAIL in Mononuclear Cells After Myocardial Infarction

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概要

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• Tumor necrosis factor (TNF) family proteins including TNF-α and Fas (CD95)-ligand have been implicated in the development of acute myocardial infarction (AMI). We studied whether AMI patients displayed up-regulation of another TNF family member, TNF-related-apoptosis-inducing ligand (TRAIL), on peripheral blood mononuclear cells (PBMCs). We compared expression of TRAIL on PBMCs from 26 patients in the acute phase of AMI with that on PBMCs from 16 healthy control subjects using flow cytometry and RT-PCR. In addition, expression of TRAIL protein on PBMCs from patients in the acute phase of AMI was also compared with that from the same patients 7 days later. Furthermore, we compared the expression of TRAIL protein on CD4+, CD8+, CD14+, and CD19+ cells from patients in the acute phase of AMI with that from control subjects using flow cytometry. Finally, expression of the TRAIL receptors (TRAILR)-1 and TRAILR-2 in human cardiomyocytes was examined immunohistochemically. Expression of TRAIL protein was significantly higher in the acute phase of AMI than in control subjects. Expression of TRAIL protein was significantly higher in the acute phase of AMI than 7 days later. TRAIL mRNA expression in the acute phase of AMI was higher than in control subjects. Expression of TRAIL protein on CD4+ and CD14+ cells from AMI patients was significantly higher than that from control subjects. Expression of TRAILR-1 and TRAILR-2 in human cardiomyocytes was confirmed immunohistochemically. TRAIL on infiltrating CD4+ and CD14+ cells may be involved in the induction of cardiomyocyte apoptosis after AMI.

• Japanese Heart Journal Associationの論文

著者

• YAMASHINA Akira

  Second Department of Internal Medicine, Tokyo Medical University

• Yamashina Akira

  Second Department Of Internal Medicine Tokyo Medical University

• Yamashina Akira

  東京医科大学 2内

• Sasame Atsuko

  Second Department of Internal Medicine, Tokyo Medical University

• Takata Ryu

  Second Department of Internal Medicine, Tokyo Medical University

• Hara Takeshi

  Second Department of Internal Medicine, Tokyo Medical University

• Nakajima Hitoshi

  Second Department of Internal Medicine, Tokyo Medical University

• Oshima Kazutaka

  Second Department of Internal Medicine,Tokyo Medical University

• Yanase Noriko

  Department of Immunology, Tokyo Medical University

• Fukazawa Shinya

  Second Department of Internal Medicine, Tokyo Medical University

• Hata Kikumi

  Department of Immunology, Tokyo Medical University

• Mukai Kiyoshi

  First Department of Pathology, Tokyo Medical University

• Mizuguchi Junichiro

  Department of Immunology, Tokyo Medical University

• Mukai Kiyoshi

  First Department Of Pathology Tokyo Medical University

• Oshima Kazutaka

  Second Department Of Internal Medicine Tokyo Medical University

• Mizuguchi Junichiro

  Department Of Immunology Graduate School Of Medicine Kagoshima University

• Takata Ryu

  Second Department Of Internal Medicine Tokyo Medical University

• Nakajima Hitoshi

  Second Department Of Internal Medicine Tokyo Medical College Hospital

• YANASE Noriko

  Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture

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