A Study to Determine if Basic Fibroblast Growth Factor(bFGF) Reduces Myocardial Infarct Size in Acute Coronary Arterial Occlusion.

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概要

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• We investigated the angiogenic and myocardial salvage effects of bFGF. Twelve beagles with ligated left anterior descending coronary arteries were divided into two groups: a FGF group administered bFGF intravenously, and a Control group, after CAG immediately post-ligation. One week post-ligation, CAG was repeated. The heart was sliced along the short axis. For each section, the fluorescein Na staining deficit area (DA) and ratio of DA to total area (DAR), TTC staining of the infarct area (IA) and ratio of IA to total area (IAR), and Masson trichrome staining of the fibrosed area (MA) and ratio of MA to total area (MAR), were calculated. The increase in the number of collateral vessels, seen on CAG from post-ligation to 1 week later, was significantly greater in the FGF group. No significant differences in IAR or MAR were seen between the groups. However, DAR and DA/IA were significantly less in the FGF group. In conclusion, bFGF had no effect on infarct size, but stimulated the growth of collateral vessels and improved coronary blood flow in IA.

著者

• Sasame Atsuko

  Second Department of Internal Medicine, Tokyo Medical University

• Usui Mikio

  Second Department of Internal Medicine, Tokyo Medical University

• Miyagi Manabu

  Second Department of Internal Medicine, Tokyo Medical University

• Naitoh Yuichi

  Second Department of Internal Medicine, Tokyo Medical University

• Ibukiyama Chiharu

  Second Department Of Internal Medicine Tokyo Medical College

• Katoh Tomitsugu

  Second Department Of Internal Medicine Tokyo Medical University

• Tamura Ken

  Second Department Of Internal Medicine Chiba University School Of Medicine

• Rakue Hiroyuki

  Second Department Of Internal Medicine Tokyo Medical University

• Nakajima Hitoshi

  Second Department Of Internal Medicine Tokyo Medical College Hospital

• IBUKIYAMA Chiharu

  Second Depertment of Internal Medicine, Tokyo Medical University, Tokyo, Japan

• RAKUE Hiroyuki

  Second Depertment of Internal Medicine, Tokyo Medical University, Tokyo, Japan

• USUI Mikio

  Second Depertment of Internal Medicine, Tokyo Medical University, Tokyo, Japan

• MIYAGI Manabu

  Second Depertment of Internal Medicine, Tokyo Medical University, Tokyo, Japan

• SASAME Atsuko

  Second Depertment of Internal Medicine, Tokyo Medical University, Tokyo, Japan

• NAITOH Yuichi

  Second Depertment of Internal Medicine, Tokyo Medical University, Tokyo, Japan

• TAMURA Ken

  Second Depertment of Internal Medicine, Tokyo Medical University, Tokyo, Japan

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