Photodynamic Therapy for the Prevention of Intimal Hyperplasia in Balloon-Injured Rabbit Arteries
スポンサーリンク
概要
- 論文の詳細を見る
This study was performed to demonstrate accumulation of the photosensitizer hematoporphyrin derivative (HPD) in atherosclerosis and to determine whether intimal hyperplasia, the main cause of restenosis after angioplasty, can be inhibited by photodynamic therapy (PDT). Forty Japanese White rabbits were subjected to balloom endothelial injury in the common iliac artery. Five groups of rabbits, ie, immediately after, or 3, 7, 14 or 28 days after the balloom injury, were injected with HPD. These rabbits were sacrificed 24h after HPD administration, and HPD fluorescence was investigated in the injured arteries by fluorescence microscopy. Other groups of rabbits were injected with HPD 24h before PDT, and they were then subjected to intravascular Hg-Xe flashlamp irradiation immediately after (0D-PDT), or 3 days (3D-PDT), 7 days (7D-PDT), or 14 days (14D-PDT) after the balloon injury. All rabbits were sacrificed 28 days after the balloon injury, and histological sections of PDT-treated arteries were examined by light microscopy. Slight, uniform HPD accumulation was observed in the injured media immediately after the balloon injury, and throughout the entire media and the neointima on day 7. On day 14, HPD accumulation had diminished in the media and increased in the intima, and on day 28 no HPD remained in the media. In the 0D- or 3D-PDT groups, no inhibition of intimal hyperplasia was observed. In contrast, there was significant inhibition of intimal hyperplasia in the 7D- and 14D-PDT groups, and the most effective inhibition was in the 7D-PDT group. This study demonstrated that PDT with HPD inhibits smooth muscle cell growth and decreases the intimal hyperplasia response in rabbits.
- 社団法人日本循環器学会の論文
- 1999-04-20
著者
-
Asahara Takayuki
The Second Department Of Internal Medicine Tokyo Medical University
-
Ibukiyama Chiharu
Second Department Of Internal Medicine Tokyo Medical University
-
Ibukiyama Chiharu
The Second Department Of Internal Medicine Tokyo Medical University
-
Ibukiyama Chiharu
Tokyo Medical College
-
Ibukiyama Chiharu
The Second Department Of Internal Medicine Tokyo Medical College
-
Naito Yuichi
Second Department Of Internal Medicine Tokyo Medical University
-
Katoh Tomitsugu
Second Department Of Internal Medicine Tokyo Medical University
-
Usui Mikio
The Second Department of Internal Medicine, Tokyo Medical University
-
Naitoh Yuuichi
The Second Department of Internal Medicine, Tokyo Medical University
-
Katoh Tomitsugu
The Second Department of Internal Medicine, Tokyo Medical University
-
Ibukiyama Chiharu
The 2nd Department Of Internal Medicine Tokyo Medical College
-
Ibukiyama Chiharu
2nd Department Of Internal Medicine Tokyo Medical College Tokyo
-
Usui Mikio
2nd Department Of Internal Medicine Tokyo Medical University
-
Kato Tomitsugu
Second Department Of Internal Medicine Tokyo Medical College
-
Ibukiyama Chiharu
Tokyo Madical College
-
Asahara Takayuki
St. Elizabeth's Medical Center
-
Ibukiyama Chiharu
The 2nd Dept. Of Intern.med. Tokyo Medical College
関連論文
- Clinical Application of Photodynamic Therapy to Prevent Coronary Artery Stenting following Restenosis
- Enhanced expression of TNF-related-apoptosis-inducing ligand(TRAIL) and Tumor necrosis factor-α (TNF-α) in mononuclear cells after acute myocardial infarction
- The influence of reperfusion therapy to short-term cardiac rehabilitation on acute myocardial infarction
- The effect of short-term exercise training in patients after acute myocardial infarction who underwent successful reperfusion therapy.
- EVALUATION OF MYOCARDIAL VIABILITY BY ^TlCL MYOCARDIAL SCINTIGRAPHY IN THE ACUTE STAGE OF MYOCARDIAL INFARCTION
- CLINICAL STUDY OF A CORONARY ENDOSCOPIC FLUORESCENT SPECTRAL ANALYZER
- A COMPARATIVE STUDY OF THE EFFICACY OF DIRECT-PTCA AND PTCR : USING DUAL ISOTOPE SPECT
- IS056 BLOOD CELL DERIVED ENDOTHELIAL CELL PROGENITORS CEN PARTICIPATE IN ANGIOGENESIS IN ADULT.
- THE BENEFICIAL EFFECTS OF ATRIAL NATRIURETIC PEPTIDE ON ARRHYTHMIAS AND MYOCARDIAL HIGH ENERGY PHOSPHATES AFTER REPERFUSION
- Effects of Nicorandil on Aortic Input Impedance : A Comparative Study With Nitroglycerin
- P542 Analysis of Coronary Flow Velocity Components : Changes in the Component Pattern After Aortic Pressure Reduction
- P470 Ascending Aortic Pressure Can be Synthesized from Radial Arterial Pressure Using Generalized Transfer Function
- 0692 Wall Thickness and New Asynergy Durine Exercise Echocardiography
- The relationship between the Augmentation Index (AI) in the pressure pulse wave and aortic input impedance (AoImp)
- The Influence of Changes in Loading Patterns on Left Ventricular Relaxation in Humans
- TWO-DIMENSIONAL ECHOCARDIOGRAPHY(Ex-2DE)DURING EXERCISE OF PATIENTS WITH MULTIVESSEL ISCHEMIC HEART DESEASE
- UNDERESTIMATION OF EFFECT OF VASODILATOR AGENTS BY PERIPHERAL BLOOD PRESSURE MEASUREMENT;THE CAUSE AND STRATEGY
- THE INFLUENCE OF PERIPHERAL WAVE REFLECTION ON LEFT VENTRICULAR RELAXATION
- 8) THE CHANGE OF THE P LOOP MAGNITUDE DURING EXERCISE AND AFTER ANGIOTENSIN II ADMINISTRATION IN ISCHEMIC HEART DISEASE: RELATION TO HEMODYNAMICS
- P418 EXPERIMENTAL STUDY OF MULTI-SITE SEQUENTIAL VENTRICULAR PACING FOR THE SUPPRESSION OF VENTRICULAR FIBRILLATION
- Frequency, Significance, and Mechanism of Myocardial Ischemia During Daily Activities Detected by Holter Dynamic Electrocardiogram
- STUDY ON THE MAXIMAL AMPLITUDE OF AORTIC REGURGITANT MURMUR
- EXPERIMENTAL STUDIES ON ATRIAL FIBRILLATION (FURTHER STUDIES) STUDIES ON ACONITINE-ATRIAL FIBRILLATION WITH MICROELECTRODES BY MEANS OF THE ISOLATION TECHNIQUE
- Experimental Study on Atrial Fibrillation (continued) : On the Difference at Right and Left Atrium as to Occurrence and Maintenance of Aconitine Induced Fibrillation after Interatrial Block : Part II
- 130) On the Influence of Extracardiac Nerves Upon the Aconitine Induced Auricular Fibrillation
- Goldenhar Syndrome Associated With Various Cardiovascular Malformations
- -296- THE DICROTIC NOTCH POSITION ON THE PRESSURE WAVE FORM AT THE BASE OF ASCENDING AORTA : Echo Cardiography : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Photodynamic Therapy for the Prevention of Intimal Hyperplasia in Balloon-Injured Rabbit Arteries
- Accumulation of Pheophorbide a in Arteriosclerosis and Its Application to Diagnosis and Treatment
- EXPERIMENTAL STUDY ON LASER CORONARY ANGIOPLASTY USING HOT-TIP WITH CERAMICS : Myocardial Metabolism, Biochemistry : 53 Annual Scientific Meeting, Japanese Circulation Society
- -168-THE UTILITY OF THE ANGIOSCOPE-FLUORESCENCE ANALYZER SYSTEM FOR DIAGNOSIS OF ATHEROMA USING A NEW PHOTOSENSITIZER. NPe6 : Arteriosclerosis : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -1163- DIAGNOSTIC VALUE OF SPATIAL VELOCITY ELECTROCARDIOGRAM IN COMPARISON WITH RESTING THALLIUM MYOCARDIAL SCINTIGRAPHY AND TWO-DIMENSIONAL ECHOCARDIOGRAM IN PATIENT WITH EFFORT ANGINA PECTORIS(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JA
- DIAGNOSTIC VALUE OF SPATIAL VELOCITY ELECTROCARDIOGRAM-T WAVES IN PATIENTS WITH EFFORT ANGINA PECTORIS
- Adjuvant Photodynamic Therapy with Local Photosensitizer Delivery Inhibits Restenosis after Coronary Angioplasty
- -354- LACTATE THRESHOLD FOR THE EVALUATION OF VARIOUS TOTAL ARTIFICIAL HEART (TAH) CONTROL MODES
- 7) CONSIDERATION ABOUT NON-SPECIFIC ECG CHANGES IN THE EARLY STAGE OF MYOCARDIAL INFARCTION
- Fluorescence Spectrum Analysis of Atherosclerotic Plaque Using Doxycycline
- Low-Dose Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor for Angiogenesis in Canine Acute Hindlimb Insufficiency
- clinical application of the coronary fluorescence-spectrum analysis (FSA) with the use of Doxycyclin (DOXY)
- -132-THE SECOND COMPONENT OF LEFT VENTRICULAR SYSTOLIC PRESSURE
- Elevated Circulating Levels of Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor in Patients With Acute Myocardial Infarction
- Photodynamic Therapy of Atherosclerosis Using YAG-OPO Laser and Porfimer Sodium, and Comparison With Using Argon-Dye Laser
- Early Occurrence of Respiratory Muscle Deoxygenation Assessed by Near-Infrared Spectroscopy During Leg Exercise in Patients With Chronic Heart Failure
- Skeletal Muscle Deoxygenation During Exercise Assessed by Near-Infrared Spectroscopy and its Relation to Expired Gas Analysis Parameters
- VENTILATORY THRESHOLD AND SKELETAL MUSCLE OXYGENATION DURING EXERCISE EVALUATED BY NEAR-INFRARED SPECTROSCOPY
- The prognostic significance of exercise-induced silent ST-segment depression in patients after myocardial infarction
- -0451-EVALUATION OF ANAEROBIC THRESHOLD AS THE OPTIMAL EXERCISE TRAINING INTENSITY FOR PATIENTS WITH CORONARY ARTERY DISEASE
- -0886-EXPERIMENTAL STUDY ON PROTECTION OF ISCHEMIC MYOCARDIUM BY PRECONDITIONING : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- A STUDY OF THE CARDIAC COMPLICATIONS IN DIABETICS : USEFULNESS OF STRESS THALLIUM IMAGING AND GATED BLOOD POOL SCINTIGRAPHY : RI : 53 Annual Scientific Meeting, Japanese Circulation Society
- EFFECT OF MYOCARDIAL SQUEEZING IN HYPERTROPHIC CARDIOMYOPATHY : EXAMINATION USING WASHOUT RATE IN^ T1 EXERCISE MYOCARDIAL SCINTIGRAPHY : Tl-201 Scintigraphy : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -0255-RELATION OF TYPE A BEHAVIOR PATTERN (TABP) TO TRADITIONAL CORONARY RISK FACTORS AND PSYCHOLOGICAL FACTORS
- -507-MYOCARDIAL METABOLIC CHANGES OF NON-ISCHEMIC MYOCARDIUM IN DOGS WITH CORONARY LIGATION : Myocardial Infarction : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- EXERCISE TOLERANCE FOR PREDICTING THE RESPONSE OF ANGINAL PAIN TO MEDICATION : Exercise Testing Ischemia : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- EXERCISE TOLERNCE IN PATIENTS WITH ANGINA PECTORIS, EFFORT : DIAGNOSTIC RELIABILITY OF ETI AND HRI : Excercise Test : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
- Exercise Parameters for the Prediction of Post-training Increase in Exercise Tolerance in Patient with Stable Angina Pectoris : Cardiac Rehabilitation
- EVALUATION OF LEFT VENTRICULAR DIASTOLIC PROPERTIES IN NORMAL SUBJECTS AND PATIENTS WITH CORONARY ARTERY DISEASE USING AFTERLOAD STRESS : Ventricular Function : 46th Annual Scientific Meeting, Japanese Circulation Society
- HEMODINAMIC EFFECTS OF DILTIAZEM IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY : A STUDY BY PULSED DOPPLER TECHNIQUE AND MULTI GATED BLOOD POOL IMAGING : Hemodynamics, Cardiac Function (IV) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
- 16)STUDY ON ELECTROCARDIOGRAPHIC PATTERN OF EARLY EXCITATION AT POSTEROBASAL PORTION OF LEFT VENTRICLE : THE II CONFERENCE ON VECTORCARDIOGRAPHY
- -210- LEFT VENTRICULAR FILLING DYNAMICS IN ISCHEMIC HEART DISEASE AND HYPER-TROPHIC CARDIOMYOPATHY : Cardiac : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- A Study to Determine if Basic Fibroblast Growth Factor(bFGF) Reduces Myocardial Infarct Size in Acute Coronary Arterial Occlusion.
- Sudden Cardiac Death from Hypertrophic Cardiomyopathy and Acute Idiopathic (Fiedler's) Myocarditis: Autopsy Report.