The Influence of Changes in Loading Patterns on Left Ventricular Relaxation in Humans
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概要
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This clinical investigation was designed to determine the effect of changes in loading patterns on left ventricular(LV)relaxation when heart rate was maintained constant. Not only were changes noted in total load or time in which load is changed, but also the contour of the ascending aortic systolic pressure wave. Twenty patients were studied. LV and ascending aortic pressure were measured by a multisensor catheter under baseline conditions(C)and after an intravenous injection of 2.5 μg angiotensin(A)and sublingual administration of 0.3 mg nitroglycerin(N). A bipolar pacing catheter was placed in the right atrium to maintain a constant heart rate throughout the protocol. The augmentation index(AI), which characterizes the contour of the ascending aortic systolic pressure wave, was defined as the ratio of the height of the late systolic shoulder/peak to that of the early systolic shoulder/peak in the pulse. The rate of isovolumic LV pressure decline was calculated as a time constant(Tau). Ascending aortic systolic pressures(mmHg)were 127±29(C), 158±20(A)and 109±15(N). AI were 1.61±1.14(C), 2.08±1.11(A)and 1.27±1.14(N). Tau values(msec)were 49±4(C), 54±4(A)and 45±5(N). Tau was prolonged proportionally with increasing AI(p<0.001, r=0.64). It was concluded that late systolic pressure augmentation in the ascending aorta is one important factor that influences the rate of isovolumic left ventricular pressure decline in humans.
- 社団法人日本循環器学会の論文
- 1998-07-20
著者
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Takazawa Kenji
Division Of Cardiology Hachioji Medical Center Tokyo Medical University Department Of Cardiology Tok
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Ibukiyama Chiharu
The second division of internal medicine, Tokyo medical college
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Ibukiyama Chiharu
The Second Department Of Internal Medicine Tokyo Medical University
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Ibukiyama Chiharu
The Second Department Of Internal Medicine Tokyo Medical College
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Takazawa Kenji
The Second Department of Internal Medicine, Tokyo Medical University
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Iketani Toshiro
The Second Department of Internal Medicine, Tokyo Medical College
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Takazawa Kenji
Division Of Cardiology Hachioji Medical Center Tokyo Medical University
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Ibukiyama Chiharu
The 2nd Department Of Internal Medicine Tokyo Medical College
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Takazawa Kenji
Cardiology Of Hachioji Medical Center Tokyo Medical University
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Iketani Toshiro
The Second Department Of Internal Medicine Tokyo Medical College
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Takazawa Kenji
Department Of Internal Medicine Tokyo Medical College Hospital
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Takazawa Kenji
The Second Department Of Internal Medicine Tokyo Medical College
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Ibukiyama Chiharu
Department Of Internal Medicine Tokyo Medical Colle9e Hospital
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Takazawa Kenji
Division Of Cardiology Hachioji Medical Center Tokyo Medical University Department Of Cardiology Tok
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Iketani Toshirou
The 2nd Department Of Internal Medicine Tokyo Medical College
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