Early Occurrence of Respiratory Muscle Deoxygenation Assessed by Near-Infrared Spectroscopy During Leg Exercise in Patients With Chronic Heart Failure

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The mechanisms of respiratory muscle deoxygenation during incremental leg exercise with expired gas analysis were investigated in 29 patients with chronic heart failure and 21 normal subjects. The deoxygenation and blood volume of the respiratory muscle and exercising leg muscle were assessed by near-infrared spectroscopy(NIRS). To evaluate the influence of the leg exercise on the blood volume of the respiratory muscle, 10 normal subjects also underwent a hyperventilation test with NIRS. The respiratory muscle deoxygenation point(RDP), at which oxygenated hemoglobin starts to decrease, was observed in both groups during exercise. The oxygen consumption(VO_2)and the minute ventilation at the RDP in the patients was lower(p<0.01). At the same VO_2, the respiratory rate was higher in patients(p<0.01). During exercise, the blood volume of the leg muscle increased, while that of the respiratory muscle decreased. During a hyperventilation test, the minute ventilation was higher than that of the RDP during exercise, the blood volume of the respiratory muscle did not decrease, and the RDP was not detectable. In conclusion, a limited ability to increase perfusion of respiratory muscles during exercise combined with the greater work of breathing results in early respiratory muscle deoxygenation in patients with chronic heart failure.
社団法人日本循環器学会の論文
1999-01-20