EFFECTS OF ALPHA HUMAN ATRIAL NATRIURETIC POLYPEPTIDEON THE SYSTEMIC HEMODYNAMICS AND CORONARY CIRCULATION IN PATIENTS WITH ISCHEMIC HEART DISEASE
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概要
- 論文の詳細を見る
Alpha human atrial natriuretic polypeptide (α-hANP) was intravenously infused into 7 patients with ischemic heart disease who had almost normal cardiac function at a rate of 0.025 μg/kg/min for 15 min. During infusion of α-hANP, left ventricular (LV) systolic pressure decreased from 144 ± 19 (SD) to 129 ± 22 mmHg (p < 0.01), LV end diastolic pressure (EDP) from 15 ± 5 to 13 ± 4 mmHg (p < 0.05), mean aortic pressure from 102 ± 14 to 91 ± 14 mmHg (p < 0.01), time constant of LV pressure fall (T) from 100 ± 15 to 88 ± 13 msec (p < 0.05), systemic vascular resistance (SVR) from 1711 ± 206 to 1424 ± 340 dynes・sec・cm^<-5> (p < 0.05) and coronary vascular resistance (CVR) from 8.5 ± 1.2 to 7.4 ± 1.3 × 10^4 dynes・sec・cm^<-5> (p < 0.05). There was a linear correlation between percent changes in SVR and those of CVR (r=0.92, p < 0.01), and the fall in CVR was approximately 68% of that in SVR. Increases occurred in heart rate from 63 ± 7 to 66 ± 8 beats/min (p < 0.05), LV dp/dt from 1558 266 to 1627 238 mmHg/sec (p 0.05), LV dp/dt/p from 22.9 3.2 to 25.6 3.7/sec (p 0.01), and myocardial oxygen consumption (from 7.9 2.4 to 9.8 2.1 ml/min, p 0.05), while mean right atrial and mean pulmonary arterial pressures and pulmonary vascular resistance were unchanged. -hANP dilates the systemic and coronary resistance vessels, and increases myocardial shortening velocity and relaxation.
- 社団法人日本循環器学会の論文
- 1988-10-20
著者
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OMAE Teruo
National Cardiovascular Center
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Sato Hiroshi
The Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Kaneko Yoshihiro
Second Department Of Internal Medicine Yokohama City University Hospital
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Omae Teruo
琉球大学 第3内科
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Ornae Teruo
Second Dept. Of Intern. Med. Kyushu Univ. School Of Med.
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Takahashi Toshiyuki
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Iizuka Masahiko
The second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Miyahara Mitsuo
The Second Department Of Internal Medicine Sapporo Medical College
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Kaneko Yoshihiro
Department Of Internal Medicine Jikei University School Of Medicine
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Kobayashi Yoshio
Cardiovascular Division National Cardiovascular Center
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Oyama Tomomi
千葉大学 循環病態医科学
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ISHII MASAO
The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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MATSUOKA HIROAKI
The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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HIRATA YASUNOBU
The Second Department of Internal Medicine, University of Tokyo
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Omae T
National Cardiovascular Center
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Sugimoto T
The Second Department Of Internal Medicine
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Sugimoto Tsuneaki
The Second Department Of Internal Medicine Toyama Medical And Pharmaceutical University
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Kohmoto Osami
The Second Department of Medicine, Saitama Medical School
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TAKAHASHI Toshiyuki
The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Serizawa Takashi
The Second Department of Internal Medicine, Saitama Medical School
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Iizuka Masahiko
The Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Ohe Tooru
Department Of Cardiovascular Medicine Okayama University Medical School
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Omae Teruo
2nd Div. Dept. Of Intern. Med. (prof. S. Katsuki) Facul. Of Med. Kyushu University Fukuoka
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Kohmoto Osami
The Second Department Of Medicine Saitama Medical School
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Hirata Yasunobu
The Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Kohmoto Osami
The Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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KANGAWA KENJI
The Second Department of Biochemistry, Miyazaki Medical College
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MATSUO HISAYUKI
The Second Department of Biochemistry, Miyazaki Medical College
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Takahashi Tomiko
Department Of Cardiovascular Medicine University Of Tokyo
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Masuo Masatoshi
The Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Omae Teruo
Division Of Hypertension And Renal Diseases Department Of Medicine National Cardiovascular Center Ho
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Omae Teruo
The 2nd Depatment Of Internal Medicine And Department Of Anatomy Faculty Of Medicine Kyusyu Universi
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OHYA Tetsuo
The Second Department of Internal Medicine Faculty of Medicine, University of Tokyo
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Kaneko Yoshihiro
The Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Sugimoto Tsuneaki
The Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Ishii Masao
The Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Takahashi Toshiyuki
Department Of Cardiovascular Medicine University Of Tokyo Graduate School Of Medicine
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Serizawa Takashi
The Second Department Of Internal Medicine Saitama Medical School
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Ishii Masao
University Of Tokyo Second Dept. Of Internal Medicine
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KIMURA YOSHIO
The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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SATO HIROAKI
The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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MOCIHZUKI TAKATOSHI
The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Takahashi Tomiko
Department Of Laboratory Medicine University Of Tokyo
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Mori Masaki
Division Of Gene Therapy Science Osaka University
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Ishii Masao
Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Yoshihiro Kanako
Second Department Of Internal Medicine Yokohama City University Hospital
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SATO Hiroshi
Tsukuba Research Institute, Sumitomo Forestry Co. Ltd.
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Kaneko Y
Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Iio Masahiro
The Department Of Radiolocrv Universitv Of Tokyo
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Toshimori Tsukasa
2nd Dept. Of Biochem. Miyazaki Med. Coll.
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Mochizuki Takatoshi
The Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Kimura Yoshio
2nd Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Ohya Tetsuo
2nd Dept. Of Internal Medicine Fac. Of Medicine Univ. Of Tokyo
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Miyahara Mitsuo
Second Department Of Internal Medicine Sapporo Medical College
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Ohya Tetsuo
The Second Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Satonaka Hiroshi
Department Of Nephrology And Endocrinology Graduate School Of Medicine University Of Tokyo
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Yoshinaga Keiichiro
Department Of Photobiology Division Of Molecular Cellular Imaging Hokkaido University Graduate Schoo
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