SEQUENTIAL CHANGES IN URINARY CATECHOLAMINE IN THE TRANSITION FROM BENIGN TO MALIGNANT HYPERTENSION IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
The sequential changes in 24-hour urinary norepinephrine (NE) and epinephrine (E) excretion levels were measured in spontaneously hypertensive rats (SHR) that received deoxycorticosterone acetate (DOCA) and 1% NaCl drinking water. These were compared with those from control SHR and similarly treated Wistar-Kyoto rats (WKY). Blood pressure, NE and E increased progressively in DOCA-SHR group, and NE (2392 ± 94 vs. 998 ± 49 ng/day) and E (250 ± 21 vs. 116 ± 6 ng/day) exceeded twice that of the control SHR group in the sixth week of DOCA treatment. In WKY rats, NE (1372 ± 48 vs. 968 ± 37 ng/day) and E (147 ± 9 vs. 121 ± 7 ng/day) levels were significantly higher in rats given DOCA than those in control group in the sixth week of the treatment, but were not so remarkably high as in DOCA-SHR group. A histological examination of DOCA-SHR kidneys revealed fibrinoid necrosis in the vascular walls. These data suggest that sympathoadrenal activity plays an important role in the development of malignant hypertension in DOCA-SHR group.
- 社団法人日本循環器学会の論文
- 1988-02-20
著者
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Kaneko Yoshihiro
Second Department Of Internal Medicine Yokohama City University Hospital
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SHIONOIRI Hiroshi
Second Department of Internal Medicine, Yokohama City University School of Medicine
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Kaneko Yoshihiro
Department Of Internal Medicine Jikei University School Of Medicine
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Kobayashi Yoshio
Cardiovascular Division National Cardiovascular Center
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SESOKO SHOJI
Second Department of Internal Medicine, Yokohama City University Hospital
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IWASAWA HIROSHI
Second Department of Internal Medicine, Yokohama City University Hospital
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AKEMA NORIKO
Second Department of Internal Medicine, Yokohama City University Hospital
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MATSUKAWA TOSHIYOSHI
Second Department of Internal Medicine, Yokohama City University Hospital
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SUGIYAMA KAZUHIDE
Second Department of Internal Medicine, Yokohama City University Hospital
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Sesoko Syoji
Second Department Of Internal Medicine Yokohama City University
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Sesoko Shoji
Second Department Of Internal Medicine Yokohama City University Hospital
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Sesoko Shoji
Second Department Of Internal Medecine Yokohama City University School Of Medicine
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Akema Noriko
2nd Dept. Of Int. Med. Yokohama City University School Of Medicine
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Akema Noriko
Second Department Of Internal Medicine Yokohama City University Hospital
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Iwasawa Hiroshi
Second Department Of Internal Medicine Yokohama City University Hospital
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Sionoiri Hiroshi
2nd Department Of Internal Medicine Yokohama City University
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Kaneko Yoshihiro
The Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Sugiyama Kazuhide
Second Department Of Internal Medicine Yokohama City University Hospital
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Matsukawa Toshiyoshi
Second Department Of Internal Medicine Yokohama City University
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Matsukawa Toshiyoshi
Second Department Of Internal Medicine Yokohama City University Hospital
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Shionoiri Hiroshi
Second Department Of Internal Medicine Yokohama City University Hospital
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Shionoiri Hiroshi
2nd Department Of Internal Medicine Yokohama City University
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Yoshihiro Kanako
Second Department Of Internal Medicine Yokohama City University Hospital
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Kaneko Y
Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Shionoiri Hiroshi
Graduate School Of Science And Technology Niigata University
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Shionoiri Hiroshi
The Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Kimura Yoshio
2nd Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Yoshinaga Keiichiro
Department Of Photobiology Division Of Molecular Cellular Imaging Hokkaido University Graduate Schoo
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