The Baroreflex-Mediated Changes Plasma Norepinephrine and Heart Rate in Patients with Essential Hypertension
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概要
- 論文の詳細を見る
Baroreflex sensitivity was evaluated in 19 patients with essential hypertension (EH), 8 patients with borderline hypertension (BH) and 12 age-matched normal controls (N), by measuring the reflex-mediated changes in plasma norepinephrine (NE) and heart rate (RR interval) while a phenylephrine hydrochloride or a sodium nitroprusside solution was infused in graded doses for a total of 24 minutes. Changes in RR interval and plasma NE showed a significant linear correlation to those in mean arterial pressure (MAP) in every subject studied. The slopes of RR/MAP and %NE/MAP tended to be reduced in EH and BH patients during both pressor and depressor stimulations. There was a significant (p<0.01) inverse correlation between the basal MAP levels an RR/MAP or %NE/MAP except for %NE/MAP during pressor stimulation. Fifteen minutes after the pressor stimulation was stopped, MAP and RR interval in each group tended to be greater than their baselines. Plasma NE remained significantly (p<0.01) depressed in N and BH subjects while those in EH returned to their baselines. When pressor stimulations were repeated twice at intervals of 15 minutes in hypertensive subjects, the second response curves of MAP-RR interval tended to shift slightly to the right while the slopes of the second response curves of plasma NE were significantly (p<0.05) reduced compared with the first ones. These findings indicate that an inability of the baroreflex to produce a sustained suppression of sympathetic nerve activity associate with an efficient ability to reset at the higher pressure levels in EH patients results in a continued tendency for blood pressure to rise and contributes to the development of hypertension.
- 社団法人日本循環器学会の論文
- 1987-10-20
著者
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Kaneko Yoshihiro
Second Department Of Internal Medicine Yokohama City University Hospital
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Yoshida K
Furukawa City Hospital
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Yoshinaga Kaoru
The Second Department Of Internal Medicine Tohoku University School Of Medicine
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Kobayashi Yoshio
Cardiovascular Division National Cardiovascular Center
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NOSHIRO TAKAO
The Second Department of Internal Medicine,Tohoku University School of Medicine
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Sano Naoki
East Japan Railway Sendai Hospital
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Miura Yukio
The Department Of Informatics On Pathophysiology Tohoku University Graduate School Of Information Sc
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Miura Yukio
The Second Department Of Internal Medicine Tohoku University School Of Medicine
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Noshiro Takao
The Second Department Of Internal Medicine Tohoku University School Of Medicine
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Noshiro Takao
The Second Department Of Internal Medicine
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SUGAWARA Takashi
The Second Department of Internal Medicine
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TAKAHASHI Masaki
Sendai Municipal Hospital
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Watanabe Hiroshi
The Second Department of Surgery Niigata University School of Medicine
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Miura Yukio
Department Of Internal Medicine Tohoku University School Of Medicine
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Yoshinaga Kaoru
Dept. Of Intern. Med. Tohoku Univ. Shool Of Medicine
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Kaneko Yoshihiro
The Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Ishizuka Yuki
The Second Department Of Internal Medicine Tohoku University School Of Medicine
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Miura Yukio
The 2nd Department Of Internal Medicine Tohoku University School Of Med
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ISHZUKA YUKI
The Second Department of Internal Medicine, Tohoku University School of Medicine
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KIMURA SHINOBU
The Second Department of Internal Medicine, Tohoku University School of Medicine
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OHASHI HIROBUMI
The Second Department of Internal Medicine, Tohoku University School of Medicine
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TAKAHASHI MASAKI
The Second Department of Internal Medicine, Tohoku University School of Medicine
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SANO NAOKI
The Second Department of Internal Medicine, Tohoku University School of Medicine
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OHASHI HIROFUMI
The Second Department of Internal Medicine, Tohoku University School of Medicine
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Kimura Shinobu
The Second Department Of Internal Medicine Tohoku University School Of Medicine
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Ohashi Hirofumi
The Second Department Of Internal Medicine Tohoku University School Of Medicine
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Miura Y
The Department Of Informatics On Pathophysiology Tohoku University Graduate School Of Information Sc
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Kimura Shinobu
The 2nd Department Of Internal Medicine Tohoku University School Of Medicine
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Kimura Yoshio
2nd Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Yoshinaga Kaoru.
The 2nd Department Of Internal Medicine Tohoku University School Of Med
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Watanabe Hiroshi
The Second Department Of Internal Medicine Tohoku University School Of Medicine
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Yoshinaga Keiichiro
Department Of Photobiology Division Of Molecular Cellular Imaging Hokkaido University Graduate Schoo
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Miura Yukio
The Department Of Informatics On Pathophysiology Tohoku University Graduate School Of Information Sc
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