Implication of Endogenous Prostaglandin System in the Antihypertensive Effect of Captopril,SQ14225, in Low Renin Hypertension : IX Conference on the Pathogenesis of Hypertension

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概要

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• The role of endogenous prostaglandins in the antihypertensive mechanism of orally active angiotensin I-converting enzyme inhibitor in low renin hypertension was investigated. In the SQ 14225-responders with low renin hypertension, blood pressure was elevated to control level and antihypertensive effect of SQ 14225 was attenuated after the inhibition of endogenous prostaglandin synthesis with indomethacin, while no significant change in blood pressure was found in the SQ 14225-responders with normal renin hypertension. Urinary prostaglandin E excretion was not significantly increased after the SQ 14225 administration but significantly decreased after the administration of indomethacin. There was no significant difference in urinary prostaglandin E excretion between normal renin hypertension and low renin hypertension. These results suggest that SQ 14225 may potentiate extrarenal vasodilating prostaglandin system, probably vascular prostaglandin system, contributing to the antihypertensive mechanism in SQ 14225-responders with low renin hypertension. The augmented renin release following SQ 14225 administration was inhibited by indomethacin, suggesting that endogenous prostaglandin system may contribute to the negative short feedback mechanism of renin release.

• 社団法人日本循環器学会の論文
• 1980-06-20

著者

• IMAI Yutaka

  Department of Clinical Pharmacology and Therapeutics, Tohoku University

• Sato Makito

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• Sato Makito

  Department Of Dermatology Sapporo Medical University

• Imai Yutaka

  Department Of Clinical Pharmacology And Therapeutics Tohoku University

• Imai Yutaka

  東北大学 臨床薬学

• Yoshida K

  Furukawa City Hospital

• Inoue Taku

  Third Department On Internal Medicine University Of The Ryukyus

• Goto Toshikazu

  Department Of Neurological Surgery Nihon University School Of Medicine

• Sakurai Yutaka

  Department of Preventive Medicine and Public Health, National Defense Medical College

• Sakurai Yutaka

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• HARUYAMA TOSHIAKI

  The Second Department of Internal Medicine, Tohoku University School of Medicine

• ABE KEISHI

  Department of Internal Medicine, Tohoku University School of Medicine

• ITOH TORU

  Department of Internal Medicine, Tohoku University School of Medicine

• HARUYAMA TOSHIAKI

  Department of Internal Medicine, Tohoku University School of Medicine

• OTSUKA YOICHI

  Department of Internal Medicine, Tohoku University School of Medicine

• YOSHINAGA KAORU

  Department of Internal Medicine, Tohoku University School of Medicine

• Goto Toshikazu

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• Goto Toshikazu

  Department Of Electrical Engineering Faculty Of Engineering Science Osaka University

• Abe Koji

  The Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University

• Abe Keishi

  Department Of Internal Medicine Tohoku University School Of Medicine

• Otsuka Yoichi

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• Sakurai Yutaka

  Department Of Hygiene National Defense Medical College

• Itoh Toru

  Department Of Internal Medicine Tohoku University School Of Medicine

• Sato Ko

  Tohoku Univ. Sendai Jpn

• Abe K

  Tohoku University

• Haruyama Toshiaki

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• Saito K

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• Yoshinaga Kaoru

  Department Of Internal Medicine Tohoku University School Of Medicine

• Ichikawa Takaharu

  Department Of Urology Okayama University Medical School

• Abe Keishi

  Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University

• Yoshida Kazunori

  Department Of Internal Medicine And Rehabilitation Science Tohoku University Graduate School Of Medi

• Yoshinaga Kaoru.

  The 2nd Department Of Internal Medicine Tohoku University School Of Med

• GOTO Toshikazu

  Depart-ment of Internal Medicne Yamagata Prefectural Central Hospital

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