Exaggerated response of renin secretion to captopril (SQ 14225) in renovascular hypertension.

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概要

• 論文の詳細を見る

• Captopril (SQ 14225), an orally active converting enzyme inhibitor, was administered in a dose of 50mg to 12 normotensive subjects (Group I), 26 essential hypertensive patients (Group II), and 8 renovascular hypertensive patients (Group III). In Group III, 5 of the 8 patients had control plasma renin activity (PRA) similar to those in Groups I and II patients, but the PRA response to the administration of captopril was greater in 7 of the 8 patients than those in Groups I and II. These 7 patients had either bilateral or unilateral main renal artery stenosis. Captopril caused no increase in PRA in the remaining 1 who had unilateral renal artery stenosis with contralateral renal aplasia.It is concluded that this provocation test is useful as a screening procedure for the diagnosis of renovascular hypertension.

• International Heart Journal 刊行会の論文

著者

• Sato Makito

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• Sato Makito

  Department Of Dermatology Sapporo Medical University

• Imai Yutaka

  Department Of Clinical Pharmacology And Therapeutics Tohoku University

• ABE KEISHI

  Department of Internal Medicine, Tohoku University School of Medicine

• HARUYAMA TOSHIAKI

  Department of Internal Medicine, Tohoku University School of Medicine

• OTSUKA YOICHI

  Department of Internal Medicine, Tohoku University School of Medicine

• YOSHINAGA KAORU

  Department of Internal Medicine, Tohoku University School of Medicine

• OMATA KEN

  Department of Internal Medicine, Tohoku University School of Medicine

• HIWATARI MASAO

  Department of Internal Medicine, Tohoku University School of Medicine

• ITO TORU

  Department of Internal Medicine, Tohoku University School of Medicine

• Sakurai Yutaka

  Department Of Hygiene National Defense Medical College

• Sato Ko

  Tohoku Univ. Sendai Jpn

• Ito Toru

  Department Of Biotechnology The University Of Tokyo

• Yoshinaga Kaoru

  Department Of Internal Medicine Tohoku University School Of Medicine

• Abe Keishi

  Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University

• Hiwatari Masao

  Department Of Cardiovascular Surgery Nihon University School Of Medicine

• SATO Makito

  Department of Internal Medicine, Tohoku University School of Medicine

• SAKURAI Yutaka

  Department of Internal Medicine, Tohoku University School of Medicine

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