Cardiohemodynamic Effects of SK&F 24260, D 600, Diltiazem, Dilazep, and Trimetazidine in the Dog
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概要
- 論文の詳細を見る
The cardiohemodynamic effects of a hypotensive agent, SK & F 24260, and coronary vasodilators, diltiazem, dilazep, and trimetazidine, and D 600 were studied in anesthetized open-chest dogs. The systemic blood pressure, cardiac output (pulmonary arterial flow), venous return (sum of the inferior and superior caval flow), right atrial pressure and heart rate were measured. All 5 drugs decreased the systemic blood pressure and heart rate and increased the right atrial pressure. The venous return and the cardiac output were reduced by higher doses of all the 5 drugs. However, SK & F 24260 in a wide range of doses greatly and diltiazem slightly but clearly increased the venous return and cardiac output. It appears that SK & F 24260 affects predominantly blood vessels whereas the other drugs affect rather the heart to produce a negative inotropic action.
- International Heart Journal刊行会の論文
著者
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IMAI Yutaka
Department of Clinical Pharmacology and Therapeutics, Tohoku University
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Imai Yutaka
Department Of Clinical Pharmacology And Therapeutics Tohoku University
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Taira Norio
Department of Pharmacology, Tohoku University School of Medicine
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Taira Norio
Department Of Pharmacology Tohoku University School Of Medicine
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HIMORI Norio
Department o f Pharmacology, Tohoku University, School of Medicine
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IMAI Yutaka
Department of Pharmacology, Tohoku University School of Medicine
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HIMORI Norio
Department of Pharmacology, Tohoku University School of Medicine
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TAIRA Norio
Department o f Pharmacology, Tohoku University, School of Medicine
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