CIRCUMSTANTIAL EVIDENCE FOR INCREASED POTASSIUM CONDUCTANCE OF MEMBRANE OF CARDIAC MUSCLE BY 2-NICOTINAMIDOETHYL NITRATE (SG-75)
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概要
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The mechanism of action of 2-nicotinamidoethyl nitrate (SG-75), was investigated by the use of arterially blood-perfused papillary muscle preparations of the dog. All drugs were administered intra-arterially. SG-75 shortened the effective refractory period (ERP) and decreased the rate of automaticity and developed tension of the papillary muscle, whereas verapamil failed to change the ERP despite a decrease in the developed tension. SG-75 in extremely high doses induced ventricular fibrillation. Methacholine produced decreases in the rate of automaticity and developed tension, and the actions were abolished by atropine. The SG-75-induced decreases in two parameters were not modified by atropine. These results indicate that the cardiac action of SG-75 differs from that of calcium-antagonistic vasodilators and it is suggested that the basic mechanism of action of SG-75 involves an increase in potassium conductance in the membrane of cardiac muscle, without mediation through muscarinic receptors.
- 社団法人 日本薬理学会の論文
著者
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Satoh Keisuke
Department Of Pharmacology Tohoku University School Of Medicine
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Satoh Keisuke
Department Of Pathophysiological And Therapeutic Science Division Of Molecular Pharmacology Tottori
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Taira Norio
Department of Pharmacology, Tohoku University School of Medicine
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YANAGISAWA Teruyuki
Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine
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Yanagisawa Teruyuki
Department Of Molecular Pharmacology Tohoku University Graduate School Of Medicine
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Taira Norio
Department Of Pharmacology Tohoku University School Of Medicine
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TAIRA Norio
Department o f Pharmacology, Tohoku University, School of Medicine
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