Relaxation of airway smooth muscle induced by potassium in the presence of Ca-antagonists.
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概要
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We examined K<SUP>+</SUP>-induced relaxation instead of contraction in the presence of Ca-antagonists by measuring isometric tension in the tracheal smooth muscle isolated from guinea pigs. Cumulative administration of KCI (10-90 mM) induced a concentration-dependent contraction. When the muscle was pretreated with low concentrations of Ca-antagonists, cumulative administration of KCI caused a mild contraction, followed by a moderate relaxation. In the muscle pretreated with high concentrations of Ca-antagonists, KCI revealed a concentration-related relaxation without contraction. The potency ratios of Ca-antagonists to reverse the KCI-induced contraction to relaxation were nifedipine : verapamil : diltiazem= 94:4:1. This order of potency was quite similar to that of Ca-antagonists to relax the muscle precontracted with KCI (30 mM). Magnitudes of KCI (30 mM)-induced relaxation in the presence of Ca-antagonists were similar to those caused by Ca-antagonists in the KCI (30 mM)-precontracted muscles. Thus, K<SUP>+</SUP>-induced relaxation in the airway smooth muscle in the presence of Ca-antagonists may be due to the voltage-dependent increase in binding of Ca-antagonists to calcium channels.
- 公益社団法人 日本薬理学会の論文
著者
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Yanagisawa Teruyuki
Department Of Molecular Pharmacology Tohoku University Graduate School Of Medicine
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Satoh Shun
Department Of Intensive Care Medicine Tohoku University School Of Medicine
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Koga Yoshihisa
Department Of Anesthesiology Kinki University Faculty Of Medicine
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TAIRA Norio
Department o f Pharmacology, Tohoku University, School of Medicine
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ENDOH Masao
epartment of Pharmacology, Yamagata University School of Medicine
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KOGA Yoshihisa
Department of Anesthesiology, Tohoku University School of Medicine
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SODEYAMA Naoya
Department of Anesthesiology, Tohoku University School of Medicine
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TESHIGAWARA Tadashi
Department of Anesthesiology, Tohoku University School of Medicine
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SATOH Shun
Department of Anesthesiology, Tohoku University School of Medicine
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