Transcutaneous Cisternal Puncture for Sampling of Cerebrospinal Fluid in Awake Rat
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概要
- 論文の詳細を見る
Reported cisternal puncture methods require the anesthetization and fixation of an animal within a stereotaxic frame. To determine the effect of anesthesia and animal fixation on the central nervous system (CNS), amino acid concentrations of cerebrospinal fluid (CSF) sampled by transcutaneous cisternal puncture were compared among awake rats, pentobarbital-anesthetized rats and pentobarbital-anesthetized rats fixed in a stereotaxic frame. Although the concentrations of many amino acids in the CSF of pentobarbital-anesthetized rats were lower than in awake rats, use of the stereotaxic frame resulted in significantly increased amino acid concentrations in the CSF. These data indicate that CSF sampling by transcutaneous cisternal puncture from awake rats is a suitable method for serial measurement of drug effects on the CNS.
- 2005-04-01
著者
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UMEDA Takashi
Department of Clinical Acupuncture, Kansai College of Oriental Medicine
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Futagawa Koichi
Department of Anesthesiology, Nara Hospital Kinki University School of Medicine
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Koga Yoshihisa
Department of Anesthesiology, Kinki University School of Medicine
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Koga Yoshihisa
近畿大学 医学部麻酔科学
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Koga Yoshihisa
Department Of Anesthesiology School Of Medicine Kinki University
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Koga Yoshihisa
Department Of Anesthesiology Kinki University School Of Medicine
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Shirai Toru
Department of Anesthesiology, Nara Hospital Kinki University School of Medicine
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Umeda Takashi
Department Of Acupuncture And Moxibustion Kansai University Of Health Sciences
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TAKASUGI Yoshihiro
Department of Anesthesiology, School of Medicine, Kinki University
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WATANABE Shinsuke
Life Science Research Institute, School of Medicine, Kinki University
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Futagawa Koichi
Department Of Anesthesiology Nara Hospital Kinki University School Of Medicine
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Futagawa Koichi
近畿大学医学部附属奈良病院 麻酔科
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Watanabe Shinsuke
Life Science Research Institute School Of Medicine Kinki University
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Shirai Toru
Department Of Anesthesiology Nara Hospital Kinki University School Of Medicine
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EGAWA Kentaro
Life Science Research Institute, Kinki University School of Medicine
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Egawa Kentaro
Life Science Research Institute Kinki University School Of Medicine
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Shirai Toru
Department Of Anesthesiology Kinki University School Of Medicine
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Takasugi Yoshihiro
Department Of Anesthesiology Kinki University School Of Medicine
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Umeda Takashi
Department Of Clinical Acupuncture Osaka Kansai College Of Oriental Medicine
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Takasugi Yoshihiro
Department Of Anesthesiology Kinki University Faculty Of Medicine
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Koga Yoshihisa
Department Of Anesthesiology Kinki University Faculty Of Medicine
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