Improvement of cardiac performance by AR-L 115 BS, a new cardiotonic drug, in the experimental failing dog heart.
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概要
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The cardiotonic effect of AR-L 115 BS was assessed in 5 dog heart-lung preparations in which cardiac function had been severely depressed by pentobarbital. AR-L 115 BS in doses of 1-60mg improved cardiac function in a dose-dependent manner and at 30 and 60mg improved it beyond control values. These doses of AR-L 115 BS, however, produced neither a significant increase in heart rate nor arrhythmias. The results indicate that the drug would be of use in the treatment of heart failure.
- International Heart Journal刊行会の論文
著者
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Satoh Keisuke
Department Of Pathophysiological And Therapeutic Science Division Of Molecular Pharmacology Tottori
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MORITA Tominori
Department of Biology, New Drug Research Laboratories, Kanebo Ltd.
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TAIRA Norio
Department o f Pharmacology, Tohoku University, School of Medicine
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MORITA Tominori
Department of Pharmacology, Tohoku University School of Medicine
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