Amelioration of heart failure by MDL 17043 and MDL 19205, novel positive inotropic drugs, in dog heart-lung preparations.
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概要
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The efficacies of MDL 17043 and MDL 19205 in ameliorating heart failure were assessed in dog heart-lung preparations in which cardiac function had been severely depressed by pentobarbital. Six preparations were used for each drug. Both drugs in doses of 1-30μmol similarly improved cardiac function in adose-dependent manner and at 30μmol improved it beyond control values. AV conduction impaired by pentobarbital was restored by 30μmol of the 2 drugs. In these doses, however, neither of the drugs produced a significant increase in heart rate or arrhythmias. These results indicate that the 2 drugs would be of use in the treatment of heart failure.
- International Heart Journal刊行会の論文
著者
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Satoh Keisuke
Department Of Pathophysiological And Therapeutic Science Division Of Molecular Pharmacology Tottori
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Nunoki Kazuo
Department Of Molecular Pharmacology Tohoku University Graduate School Of Medicine
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TAIRA Norio
Department o f Pharmacology, Tohoku University, School of Medicine
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NUNOKI Kazuo
Department of Pharmacology, Tohoku University School of Medicine
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GOTO Toshikazu
Department of Pharmacology, Tohoku University School of Medicine
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GOTO Toshikazu
Depart-ment of Internal Medicne Yamagata Prefectural Central Hospital
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