Experimental Primary Fatal Head Injury Caused by Linear Acceleration-Biomechanics and Pathogenesis

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概要

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• The present experiment was undertaken to clarify the pathogenesis of primary fatal head injury due to impact and further to obtain a severity index denoting the relationship between the magnitude of impact and the severity of head injury in animals with experimental blunt head injuries caused by simplified impact upon the cranium. The experiment was conducted on Ketalar-anesthesized rhesus monkeys. Impact was imparted to the animals by means of a 12 in. HYGE impact tester. Before and after the impact the animals were subjected to a series of examinations at intervals, including respiration, ECG, blood pressure, cerebral circulation, partial pressure of blood gases, acid-base equilibrium and EEG. Pathological examination, measurements of lactic acid and monoamine contents in various portions of the brain were also made. An impact upon the head, at an acceleration in the horizontal antero-posterior direction of 1000-1500 G and a duration of 3-4 msec, proved fatal invariably in animals weighing more than 8 kg (body weight × effective acceleration above 30 kg). In dead animals, primary injury consisting of narrowing of lumen and stoppage of blood flow in perforating arteries of the brain-stem and small hemorrhages in the same areas was noted. It was demonstrated that these changes give rise to central dysregulation of the circulatory (including heart) and respiratory systems which in turn acts on cerebral circulation and metabolism. This fact not only proves the existence of a primary fatal head injury and further clarifies its mechanism of development but also suggests the possibility of grading the severity of head injury by simplified impact and also by expressing the relationship between the magnitude of impact and the severity of brain damage as a severity index.

• 社団法人日本脳神経外科学会の論文

著者

• Goto Toshikazu

  Department Of Neurological Surgery Nihon University School Of Medicine

• Goto Toshikazu

  Department Of Electrical Engineering Faculty Of Engineering Science Osaka University

• KURISAKA Masahiro

  Department of Neurosurgery, Kochi Medical School

• Hayashi Nariyuki

  Department of Emergency and Critical care Medicine, Nihon University School of Medicine

• TAKEUCHI Totaro

  Department of Neurosurgery, The Gyoda General Hospital

• Nakamura Saburo

  Department Of Neurological Surgery Nihon University School Of Medicine

• TSUBOKAWA Takashi

  Department of Neurological Surgery, Nihon University School of Medicine

• TAGUMA Norikata

  Department of Neurological Surgery, Nihon University School of Medicine

• SUGAWARA Takehito

  Department of Neurological Surgery, Nihon University School of Medicine

• MORIYASU Nobuo

  Department of Neurological Surgery, Nihon University School of Medicine

• MIYAGAMI Mitsusuke

  Department of Neurological Surgery, Nihon University School of Medicine

• YAMADA Jitsuhiro

  Department of Neurological Surgery, Nihon University School of Medicine

• SUGAWARA Takekito

  Department of Neurological Surgery, Nihon University School of Medicine

• SHINOZAKI Hideo

  Department of Neurological Surgery, Nihon University School of Medicine

• Hayashi Nariyuki

  Department Of Neurological Surgery Nihon University School Of Medicine

• Hayashi Nariyuki

  Department Of Emergency And Critical Care Medicine Nihon University School Of Medicine

• Hayashi Nariyuki

  Department Of Neurological Surgery School Of Medicine Nihon University

• Moriyasu Nobuo

  Department Of Neurological Surgery Nihon University School Of Medicine

• Moriyasu Nobuo

  Department Of Neurological Surgery Faculty Of Medicine University Of Nihon

• Tsubokawa Takashi

  Department Of Neurological Surgery Nihon University School Of Medicine

• Tsubokawa Takashi

  Department Of Neurological Surgery School Of Medicine Nihon University

• Miyagami Mitsusuke

  Department Of Neurological Surgery School Of Medicine Nihon University

• Shinozaki Hideo

  Department Of Neurological Surgery Nihon University School Of Medicine

• Yamada Jitsuhiro

  Department Of Neurological Surgery Nihon University School Of Medicine

• Tsubokawa Takashi

  Department Of Neuroligical Surgery Nihon University School Of Medicine

• Moriyasu Nobuo

  Department Of Neurological Surgery School Of Medicine Nihon University

• Taguma Norikata

  Department Of Neurological Surgery Nihon University School Of Medicine

• Sugawara Takehito

  Department Of Neurological Surgery Nihon University School Of Medicine

• Takeuchi Totaro

  Neurosurgical Department The Municipal Of Higashimatsuyama Hospital

• Takeuchi Totaro

  Department Of Neurosurgery The Gyoda General Hospital

• Kurisaka Masahiro

  Department Of Neurological Surgery Faculty Of Medicine University Of Nihon

• Miyagami Mitsusuke

  Department Of Neurological Surgery Nihon University School Of Medicine

• Nakamura Saburo

  Department Of Internal Medicine Tsuruga City Hospital

• Sugawara Takekito

  Department Of Neurological Surgery Nihon University School Of Medicine

• Naakmura Saburo

  Department Of Neurological Surgery School Of Medicine Nihon University

• Takeuchi Tohtaro

  Department Of Neurosurgery Nihon University School Of Medicine

• GOTO Toshikazu

  Depart-ment of Internal Medicne Yamagata Prefectural Central Hospital

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