Intra-arterial ACNU Chemotherapy Employing 20% Mannitol Osmotic Blood-brain Barrier Disruption for Malignant Brain Tumors
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概要
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The clinical effects and problems of intra-arterial water-soluble antitumor nitrosourea (ACNU) therapy following osmotic blood-brain barrier modification are discussed. Twenty-one patients with malignant brain tumors were divided into two groups. Group 1 consisted of 16 patients treated by operation, irradiation, and two or more courses of intracarotid infusion of ACNU 100 mg/body (1.7-2.2 mg/kg) following 20% mannitol 200 ml (1.3-1.6 ml/sec) (7 grade 4 astrocytomas, 5 grade 3 astrocytomas, and 4 others). Group 2 consisted of five patients treated by operation, irradiation, and repeated intracarotid infusion of ACNU 100 mg/body alone (grade 4 astrocytoma). The 2-year survival rate in Group 1 was 79% (11 of 14 cases followed up for longer than 2 years) and the 3-year survival rate was 67%. Five of seven grade 4 astrocytoma patients (71%) in Group 1 survived for more than 1 year 6 months, whereas four of five grade 4 astrocytoma in Group 2 died within 1 year 6 months. The measurement of the ACNU concentration in tumor tissues and blood in 11 brain tumors, after intracarotid infusion of ACNU with blood-brain barrier disruption, showed peak values in the tumor tissues of 3.02-32.53 μg/gm (mean, 9.67 μg/gm), about three to five times as high as that in blood in most cases. This method used in Group 1 appears to be relatively safe without permanent neurological deficits and offers a potential therapeutic effect when used in combination with appropriate premedication in suitable patients.
- 日本脳神経外科学会の論文
- 1990-08-15
著者
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MIYAGAMI Mitsusuke
Department of Neurological Surgery, Nihon University School of Medicine
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Tazoe Makoto
Department Of Neurological Surgery Nihon University School Of Medicine
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Tsubokawa Takashi
Department Of Neuroligical Surgery Nihon University School Of Medicine
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Miyagami Mitsusuke
Department Of Neurological Surgery Nihon University School Of Medicine
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KAGAWA Yukihide
Department of Neurological Surgery, Nihon University School of Medicine
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Kagawa Yukihide
Department Of Neurological Surgery Nihon University School Of Medicine
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