Improvement of pentobarbital-induced heart failure by MCI-154, a novel and potent cardiotonic agent, in the dog heart-lung preparation.

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概要

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• The efficacy of MCI-154, a new pyridazinone cardiotonic agent, in improving heart failure was assessed in dog heart-lung preparations in which cardiac function had been severely depressed by pentobarbital. MCI-154 in doses of 10-100 μig improved the cardiac function curve and restored it to the control level at 100 μg. At this dose, MCI-154 neither produced an increase in heart rate beyond the control value nor induced arrhythmias. The effects of MCI-154 were not affected by atenolol, a cardioselective β<SUB>1</SUB>-blocker. These results indicate that MCI-154 would be of potential use in the treatment of heart failure.

• 公益社団法人 日本薬理学会の論文

著者

• Goto Toshikazu

  Department Of Electrical Engineering Faculty Of Engineering Science Osaka University

• Satoh Keisuke

  Department Of Pathophysiological And Therapeutic Science Division Of Molecular Pharmacology Tottori

• Hosono Makoto

  Department Of Pet Kinki University School Of Medicine

• HASHIMOTO Hiroo

  Department of Medicine III, Okayama University Medical school

• Nunoki Kazuo

  Department Of Molecular Pharmacology Tohoku University Graduate School Of Medicine

• TAIRA Norio

  Department o f Pharmacology, Tohoku University, School of Medicine

• SATO Yoshinori

  Department of Bioclimatology and Medicine. Research Institute of Bioregulation. Kyushu University

• SATO Yoshinori

  Department of Pharmacology, Tohoku University School of Medicine

• GOTO Toshikazu

  Depart-ment of Internal Medicne Yamagata Prefectural Central Hospital

• HOSONO Makoto

  Department of Pharmacology, Tohoku University School of Medicine

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