Differential effects of isoproterenol on the canine atrial action potential in the presence of carbachol or nicorandil.
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概要
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In canine atrial muscles, carbachol and nicorandil hyperpolarized the resting membrane potential and shortened the action potential duration. In the presence of carbachol or nicorandil, isoproterenol further hyperpolarized the resting membrane potential and shortened the action potential duration. Isoproterenol significantly increased the plateau duration in the presence of nicorandil, but further abbreviated it in the presence of carbachol. This increase in the plateau duration by isoproterenol in the presence of nicorandil probably reflects the increase in the slow inward current.
- 公益社団法人 日本薬理学会の論文
著者
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Endoh Masao
Department Of Cardiovascular Pharmacology Yamagata University School Of Medicine
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Iijima Toshihiko
Department Of Life And Medicine Urayasu Hospital Of Juntendo University School Of Medicine
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ENDOH Masao
Department of Pharmacology, Yamagata University School of Medicine
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TAIRA Norio
Department o f Pharmacology, Tohoku University, School of Medicine
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