Postnatal Changes in mRNA Expression of the K+ Channel in Rat Cardiac Ventricles.
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概要
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The reason for the postnatal changes of action potential duration in rat heart cells is still a matter of controversy. We have examined mRNA expression levels of Kv1.2, one of the K<SUP>+</SUP>-channel genes, in neonatal (1 week) and adult (8 weeks) rat cardiac ventricles. For analysis of mRNA expression, we used the reverse transcription-polymerase chain reaction method. The level of Kv1.2 mRNA expression in adult rats was significantly higher than that in neonatal rats. This result suggests that the levels of ion channel gene expression may be responsible for the postnatal changes of the action potential duration.
- 公益社団法人 日本薬理学会の論文
著者
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IIJIMA Toshihiko
Department of Pharmacology, Akita University School of Medicine
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Nakamura Kazuhiro
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Iijima Toshihiko
Department Of Life And Medicine Urayasu Hospital Of Juntendo University School Of Medicine
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