Clostridium difficile Infection Induced by Pregabalin-associated Agranulocytosis
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概要
- 論文の詳細を見る
A 33-year-old man who had recently undergone surgery for cervical spondylotic myelopathy was prescribed pregabalin for neuralgia, and the dose was increased to 600 mg/day during hospitalization. However, the patient was diagnosed with a Clostridium difficile infection on day 34 after admission. A complete blood count showed agranulocytosis (neutrophil count: 105/μL). We did not observe any changes in vital signs, a relative increase in band cells, or intestinal edema. The patient's agranulocytosis resolved after withdrawing pregabalin. This is the first reported case of agranulocytosis associated with pregabalin. Periodic monitoring of the white blood cell count is therefore considered to be useful in patients receiving high-dose pregabalin therapy.
- 一般社団法人 日本内科学会の論文
著者
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Uemura Kazuya
Department Of Neurosurgery Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Ito Yoshiro
Department Of Applied Chemistry School Of Engineering Nagoya University
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Suzuki Hiromichi
Division Of Bioscience And Biotechnology Department Of Environmental And Life Sciences Toyohashi Uni
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Nakamura Kazuhiro
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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MATSUMURA Akira
Department of Electronic Science and Engineering, Faculty of Engineering, Kyoto University
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Matsumura Akira
Department of Neurosurgery, University of Tsukuba Hospital, Japan
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Kino Hiroyoshi
Department of Neurosurgery, Tsukuba Medical Center Hospital, Japan
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Koiso Takao
Department of Neurosurgery, Tsukuba Medical Center Hospital, Japan
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