Anti-angiogenic and Immunomodulatory Effect of the Herbal Medicine "Juzen-taiho-to" on Malignant Glioma(Pharmacognosy)

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概要

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• Juzen-taiho-to (JTT) is known as a Japanese herbal medicine that increases the immune function via the enhancement of phagocytosis, cytokine induction, and antibody production. Anti-neoplastic effects on malignant gliomas have been reported by means of the enhancement of the immune function in both animals and humans. We evaluated whether JTT has anti-angiogenic effects on malignant glioma growth in vitro and in vivo. In vitro, the anti-proliferative effect of JTT on malignant glioma cells and endothelial cells was assessed by cell proliferation assay. In vivo, a subcutaneous model of malignant glioma with different-aged mice (old, 43 weeks; young, 8 weeks) was used. After oral administration of JTT to mice, their immunological function and angiogenic status of tumor tissues were assessed by flow cytometry and immunohistochemistry, respectively. JTT inhibited human endothelial cell, but not glioma cell, proliferation in vitro. In vivo, the NK (natural killer) cell ratio within PBMC (peripheral blood mononuclear cells) and NK activity of fresh splenocytes obtained from JTT-treated old mice were significantly increased compared to the ratio and activity in control mice. In old mice, the vessel area of tumor tissues in JTT treatment groups was significantly decreased. These enhancements of immunological function and the inhibition of angiogenic activity were not observed in young mice. JTT not only increased host immunological function but also exerted anti-angiogenic effects on malignant glioma growth. JTT would be useful as an adjuvant medicine for malignant gliomas through its enhancement of systemic immunological function and its anti-angiogenic action.

• 公益社団法人日本薬学会の論文
• 2005-11-01

著者

• MATSUMURA Akira

  Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba

• ISHIKAWA Eiichi

  Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba

• TAKANO Shingo

  Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba

• Kamiyama Hiroshi

  Department Of Cardiology Isesaki Sawa Hospital

• TSUBOI Koji

  Department of Proton Medical Research Center, Graduate School of Comprehensive Human Sciences, Unive

• Matsumura A

  茨城県立中央病院 総合診療科

• Takano Shingo

  Department Of Neurosurgery Graduate School Of Comprehensive Human Sciences University Of Tsukuba

• Takano Shingo

  Department Of Neurological Surgery Institute Of Clinical Medicine University Of Tsukuba:division Of

• Matsumura Akira

  Department Of Neurosurgery Graduate School Of Comprehensive Human Sciences University Of Tsukuba

• Tsuboi K

  Department Of Proton Medical Research Center Graduate School Of Comprehensive Human Sciences Univers

• Ishikawa Eiichi

  茨城県立中央病院 総合診療科

• Ishikawa Eiichi

  Department Of Neurosurgery Ibaraki Prefectural Central Hospital

• Ishikawa Eiichi

  Department Of Neurosurgery Ibaraki Prefectural Central Hospital:department Of Neurosurgery Tsukuba M

• Ishikawa Eiichi

  Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu University

• Ishikawa Eiichi

  Department Of Neurosurgery Institute Of Clinical Medicine Graduate School Of Comprehensive Human Sci

• Tsuboi Koji

  Department Of Neurosurgery Graduate School Of Comprehensive Human Sciences University Of Tsukuba

• Matsumura Akira

  Department Of Gastroenterology Dokkyo Medical University

• Kamiyama Hiroshi

  Department Of Neurosurgery Institute Of Clinical Medicine

• Tsuboi Koji

  Department Of Neurological Surgery Institute Of Clinical Medicine University Of Tsukuba

• Matsumura Akira

  Department Of Forest Resources Science Shizuoka University

• MATSUMURA Akira

  Department of Electronic Science and Engineering, Faculty of Engineering, Kyoto University

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