Low Peripheral Lymphocyte Count Before Focal Radiotherapy Plus Concomitant Temozolomide Predicts Severe Lymphopenia During Malignant Glioma Treatment
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概要
- 論文の詳細を見る
Malignant glioma patients treated with the golden standard therapy, focal radiotherapy plus concomitant daily temozolomide (radiotherapy/TMZ), often suffer severe lymphopenia. The frequency of severe lymphopenia and its predictors were analyzed by assessing adverse effects including decrease in white blood cell counts, lymphocyte counts, and neutrocyte counts according to the Common Toxicity Criteria version 3.0 (CTC) in 28 consecutive patients with pathologically verified malignant gliomas treated with radiotherapy/TMZ. Eighty-two percent of the patients suffered one or more adverse effects; lymphopenia (68%) was the most frequent adverse effect, with 32% of patients suffering CTC grade 4 lymphopenia. CTC grade 4 lymphopenia was associated with the incidence of other CTC grade 3 or 4 adverse effects and discontinuance of TMZ. Minimal lymphocyte counts during radiotherapy/TMZ and lymphocyte counts before radiotherapy/TMZ showed close linear correlation by linear regression analysis (p < 0.0001, R2 = 0.569), and the most important predictor for CTC grade 4 lymphopenia was lymphocyte count before radiotherapy/TMZ less than 1200/μl by multivariate analysis (p < 0.0321, Exp = 13.2). Lymphocyte counts before radiotherapy/TMZ of less than 1200/μl predict severe lymphopenia during radiotherapy/TMZ.
- 2010-08-15
著者
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YAMAMOTO Tetsuya
Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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MATSUMURA Akira
Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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ISHIKAWA Eiichi
Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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SAKAMOTO Noriaki
Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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NAKAI Kei
Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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AKUTSU Hiroyoshi
Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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TAKANO Shingo
Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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TSUBOI Koji
Department of Proton Medical Research Center, Graduate School of Comprehensive Human Sciences, Unive
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Matsumura A
茨城県立中央病院 総合診療科
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Nakai Kei
Department Of Neurosurgery Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Takano Shingo
Department Of Neurosurgery Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Takano Shingo
Department Of Neurological Surgery Institute Of Clinical Medicine University Of Tsukuba:division Of
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Matsumura Akira
Department Of Neurosurgery Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Akutsu Hiroyoshi
Department Of Neurosurgery Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Tsuboi K
Department Of Proton Medical Research Center Graduate School Of Comprehensive Human Sciences Univers
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Ishikawa Eiichi
茨城県立中央病院 総合診療科
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Ishikawa Eiichi
Department Of Neurosurgery Ibaraki Prefectural Central Hospital
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Ishikawa Eiichi
Department Of Neurosurgery Ibaraki Prefectural Central Hospital:department Of Neurosurgery Tsukuba M
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Ishikawa Eiichi
Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu University
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Sakamoto Noriaki
Department Of Neurosurgery Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Yamamoto Tetsuya
Department Of Chemical Engineering Graduate School Of Engineering Hiroshima University
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Ishikawa Eiichi
Department Of Neurosurgery Institute Of Clinical Medicine Graduate School Of Comprehensive Human Sci
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Tsuboi Koji
Department Of Neurosurgery Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Matsumura Akira
Department Of Gastroenterology Dokkyo Medical University
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Sakamoto Noriaki
Department Of Clinical Research Division Of Surgery National Shikoku Cancer Center Hospital
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Yamamoto Tetsuya
Department Of Astronomy School Of Science The University Of Tokyo
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Tsuboi Koji
Department Of Neurological Surgery Institute Of Clinical Medicine University Of Tsukuba
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Yamamoto Tetsuya
Department Of Neurosurgery Doctoral Program In Functional And Regulatory Medical Science Graduate Sc
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Akutsu Hiroyoshi
Department Of Neurosurgery University Of Tsukuba
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Matsumura Akira
Department Of Forest Resources Science Shizuoka University
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MATSUMURA Akira
Department of Electronic Science and Engineering, Faculty of Engineering, Kyoto University
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