Effects of Single Administration of a Phosphodiesterase III Inhibitor During Cardiopulmonary Bypass : Comparison of Milrinone and Amrinone
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概要
- 論文の詳細を見る
The effects of phosphodiesterase III(PDE III)inhibitors administered after aortic declamping during cardiopulmonary bypass(CPB)for open heart surgery were in vestigated. Ten patients(group M)ware administered milrinone(50 μg/kg)after aortic declamping during CPB, 10 patients were administered amrinone(1 mg/kg)at the same time during their surgery(group A), and 10 patients served as controls with no drug administered(group C). Soon after bolus infusion of the PDE III inhibitor, perfusion pressure dropped significantly in groups M and A. However, after release of CPB and at the end of surgery, there was no difference in aortic pressure between the 3 groups. There were also no differences between the groups in heart rate, pulmonary artery pressure, and pulmonary capillary wedge pressure. After weaning from CPB, the cardiac index was high and systemic vascular resistance index was low in groups M and A. There were no significant differences in the need for additional catecholamines and time for rewarming between groups. No adverse reactions were observed. A single administration of a PDE III inhibitor during CPB was useful for post-CPB management of patients undergoing open heart surgery. Amrinone reduced perfusion pressures more than milrinone, but cardiac indices and aortic pressures after weaning from CPB showed no differences between group M and group A patients.
- 社団法人日本循環器学会の論文
- 1999-07-20
著者
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YAMAMOTO Tetsuya
Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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Koh Yoshiaki
The 3rd Department Of Surgery Nara Medical College
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Hamada Yoshihiro
Department of Pathology, Faculty of Medicine, Fukuoka University
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KAWACHI Kanji
Department of Cardiovascular Surgery, Ehime University Hospital
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Kawachi Kanji
Department Of Surgery Ii Ehime University School Of Medicine
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Kawachi Kanji
Department Of Cardiovascular Surgery Ehime University Hospital
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Kawachi Kanji
愛媛大学 医学系研究科臓器再生外科学
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WATANABE YUJI
Department of Nuclear Medicine, Faculty of Medicine, Kyoto University
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Watanabe Yuji
Organ Regenerative Surgery Ehime University Graduate School Of Medicine
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NAKATA Tatsuhiro
the Department of Surgery II, Ehime University School of Medicine.
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SATO Motomichi
the Department of Surgery II, Ehime University School of Medicine.
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Nakata Tatsuhiro
Department of Surgery II, Ehime University School of Medicine
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Kashu Yasuaki
Department of Surgery II, Ehime University School of Medicine
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Sato Motomichi
Department of Surgery II, Ehime University School of Medicine
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Watanabe Yuji
Department Of Nuclear Medicine Faculty Of Medicine Kyoto University
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Hamada Yoshihiro
Department Of Surgery Ii Ehime University School Of Medicine
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Hamada Yoshihiro
Department Of Cancer Survey Osaka Medical Center For Cancer And Cvd
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Watanabe Y
Dep. Of Surgery Graduate School Of Medicine Ehime Univ.
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Kashu Yasuaki
Department Of Cardiovascular Surgery Uwajima Municipal Hospital
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Kashu Yasuaki
Department Of Surgery Ii Ehime University School Of Medicine
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Sato Motomichi
The Department Of Surgery Ii Ehime University School Of Medicine.
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Yamamoto Tetsuya
Department Of Chemical Engineering Graduate School Of Engineering Hiroshima University
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Kawachi Kanji
Department Of Organ Regenerative Surgery Ehime University Graduate School Of Medicine
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Nakata Tatsuhiro
The Department Of Surgery Ii Ehime University School Of Medicine.
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Watanabe Yuji
Department Of Molecular Neurobiology Institute Of Development Aging & Cancer Tohoku University
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Yamamoto Tetsuya
Department Of Surgery Ii Ehime University School Of Medicine
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Yamamoto Tetsuya
Department Of Astronomy School Of Science The University Of Tokyo
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Watanabe Yuji
Department Of Computational Science And Engineering Graduate School Of Engineering Nagoya University
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