Mn-Metalloporphyrin Conjugated with Gd-DTPA (Gd-ATN10): Tumor Enhancement Agent for Magnetic Resonance Imaging
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概要
- 論文の詳細を見る
A conjugate of manganese-metalloporphyrin and gadolinium (Gd)-diethylenetriaminepenta-acetic acid (Gd-ATN10) was developed as a tumor-specific enhancement agent for magnetic resonance (MR) imaging. Gd-ATN10 was evaluated in an experimental 9L gliosarcoma rat tumor model. T_1-weighted MR imaging showed enhancement of the tumor which persisted for up to 24 hours. Gd concentration measurement by inductively coupled plasma atomic emission spectroscopy revealed the peak Gd concentration was reached after 30 minutes and Gd was retained in the blood and tumor up to 24 hours. There was no uptake of Gd in the normal brain and little in the skin. Gd-porphyrin derivatives are potentially useful agents for tumor diagnosis on MR imaging and for neutron capture therapy.
- 日本脳神経外科学会の論文
- 1997-04-15
著者
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YAMAMOTO Tetsuya
Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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MATSUMURA Akira
Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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Nakajima Susumu
Department Of Orthopaedic Surgery Faculty Of Medicine The University Of Tokyo
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柴田 靖
秋本脳神経外科
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柴田 靖
北茨城市立総合病院
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柴田 靖
小川香料
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Matsumura A
茨城西南医療センター病院 脳神経外科
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NOSE Tadao
Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba
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Matsumura Akira
Department Of Neurosurgery Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Matsumura Akira
Departments Of Neurosurgery Institute Of Clinical Medicine University Of Tsukuba
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柴田 靖
筑波大学大学院 人間総合科学研究科脳神経外科
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SHIBATA Yasushi
Department of Applied Biological Science, Faculty of Science and Technology
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松村 明
Department Of Neurosurgery Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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NAKAGAWA Kunio
Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba
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YASUDA Susumu
Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba
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SAKATA Isao
Toyohakka Co. Ltd.
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YOSHIZAWA Takashi
Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba
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Shibata Yasushi
Department Of Neurosurgery Institute Of Clinical Medicine University Of Tsukuba:(present Address)dep
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Shibata Yasushi
Department Of Neurosurgery Institute Of Clinical Medicine University Of Tsukuba:department Of Neuros
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Shibata Yasushi
Department Of Agricultural Chemistry Faculty Of Agriculture Yamaguchi University
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Nose Tadao
Department Of Neurosurgery Institute Of Clinical Medicine University Of Tsukuba
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Nose Tadao
Department Of Neurological Surgery Insititute Of Clinical Medicine University Of Tsukuba
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Yasuda Susumu
Department Of Civil And Environmental Engineering Tokyo Denki University
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Yasuda Susumu
Department Of Neurosurgery Institute Of Clinical Medicine University Of Tsukuba
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Nakagawa Kunio
Department Of Neurosurgery Institute Of Clinical Medicine University Of Tsukuba
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Nakajima Susumu
Department Of Operative Surgery Asahikawa Medical College
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Yamamoto Tetsuya
Department Of Chemical Engineering Graduate School Of Engineering Hiroshima University
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Matsumura Akira
Department Of Gastroenterology Dokkyo Medical University
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Shibata Yasushi
Department Of Neurosurgery Kobari General Hospital:department Of Neurosurgery Institute Of Clinical
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Yoshizawa Takashi
Department Of Neurosurgery Institute Of Clinical Medicine University Of Tsukuba
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Yamamoto Tetsuya
Department Of Neurosurgery Institute Of Clinical Medicine University Of Tsukuba
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Yamamoto Tetsuya
Department Of Astronomy School Of Science The University Of Tokyo
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Yoshizawa Takashi
Department Of Engineering Physics The University Of Electro-communications
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Nakajima Susumu
Department of Emergency and Critical Care Medicine, The University of Tokyo Hospital, Japan
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