Allopurinol Improves Cardiac Dysfunction After Ischemia-Reperfusion via Reduction of Oxidative Stress in Isolated Perfused Rat Hearts
スポンサーリンク
概要
- 論文の詳細を見る
It has been reported that the xanthine oxidase inhibitor, allopurinol, has a protective effect on ischemia-reperfusion injury, but the precise mechanism of its action is still unclear. Therefore, in the present study the mechanisms of the myocardial protection of allopurinol were evaluated in isolated perfused rat hearts. Allopurinol significantly inhibited myocardial xanthine oxidase activity, and improved left ventricular dysfunction after ischemia-reperfusion. In addition, the lactate dehydrogenase content in the coronary effluent obtained after reperfusion was significantly decreased. ATP, ADP, AMP and IMP significantly decreased, whereas inosine, hypoxanthine and xanthine significantly increased after ischemia in both the control and allopurinol groups. The concentration of xanthine was significantly decreased after ischemia-reperfusion in the allopurinol group; however, allopurinol did not affect the other purine metabolites. To evaluate the accumulation of oxidative stress, thiobarbituric acid reactive substances (TEARS) production in myocardial tissue was measured and allopurinol significantly decreased TEARS formation after ischemia-reperfusion. Finally, myocardial hydroxyl radicals were directly measured by electron spin resonance spectroscopy with the nitroxide radical 4-hydroxy-2, 2,6,6-tetramethyl-piperidine-N-oxyl. Hydroxyl radicals significantly increased immediately after reperfusion, but were significantly decreased in the allopurinol group. In conclusion, allopurinol reduced myocardial injury after ischemia-reper-fusion by suppressing oxidative stress, but not by salvage of ATP. These findings may lead to the development of new therapeutic strategies for myocardial ischemia-reperfusion injury. (Circ J 2003; 67: 781-787)
- 社団法人日本循環器学会の論文
- 2003-08-20
著者
-
YAMAMOTO Tetsuya
Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba
-
Tsutsui Hiroyuki
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Hokkaido University
-
Ogino Kazuhide
Center for Clinical Residency Program, Tottori University Hospital
-
Furuse Yoshiyuki
Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University
-
Kinugasa Yoshiharu
Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University
-
Hisatome Ichiro
Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of
-
Shigemasa Chiaki
Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University
-
IGAWA Osamu
Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University
-
Shigemasa Chiaki
Department Of Cardiovascular Medicine Faculty Of Medicine Tottori University
-
Igawa Osamu
Sapporo Medical University
-
OGINO Kazuhide
Department of Cardiovascular Medicine, Tottori University Faculty of Medicine
-
Ogino Kazuhide
Center For Clinical Residency Program Tottori University Hospital
-
Tsutsui Hiroyuki
Department Of Cardiovascular Medicine
-
Suga Toshimitsu
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kyushu University
-
Shiomi Tetsuya
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
-
Kinugasa Yoshiharu
Department Of Cardiovascular Medicine Faculty Of Medicine Tottori University
-
Yamamoto Tetsuya
Department Of Chemical Engineering Graduate School Of Engineering Hiroshima University
-
Shiomi Tetsuya
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kyushu University
-
Furuse Yoshiyuki
Department Of Cardiovascular Medicine Faculty Of Medicine Tottori University
-
Igawa Osamu
Department Of Cardiovascular Medicine Faculty Of Medicine Tottori University
-
Yamamoto Tetsuya
Division Of Endocrinology And Metabolism Department Of Internal Medicine Hyogo College Of Medicine
-
Yamamoto Tetsuya
Department Of Astronomy School Of Science The University Of Tokyo
-
Hisatome Ichiro
Department Of Cardiology Kitano Hospital Medical Research Institute
-
Tsutsui Hiroyuki
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
-
TSUTSUI Hiroyuki
Department of Cardiology, Iizuka Hospital
関連論文
- Palladium-catalyzed 1,2-addition of alkylborane reagents to aldehydes
- Body Mass Index can Similarly Predict the Presence of Multiple Cardiovascular Risk Factors in Middle-aged Japanese Subjects as Waist Circumference
- Discharge use of angiotensin receptor blockers provides comparable effects with angiotensin-converting enzyme inhibitors on outcomes in patients hospitalized for heart failure
- Persistent Primitive Olfactory Artery Aneurysm : Case Report
- 7 Anxiety and Poor Social Support are Independently Associated with Adverse Outcomes in Patients with Mild Heart Failure(Is Stress a Risk of Cardiovascular Disease?,Symposium 22 (SY-22) (I),The 73rd Annual Scientific Meeting of The Japanese Circulation So
- Low Peripheral Lymphocyte Count Before Focal Radiotherapy Plus Concomitant Temozolomide Predicts Severe Lymphopenia During Malignant Glioma Treatment
- 7 Anxiety and Poor Social Support are Independently Associated with Adverse Outcomes in Patients with Mild Heart Failure(Is Stress a Risk of Cardiovascular Disease?,Symposium 22 (SY-22) (I),The 73rd Annual Scientific Meeting of The Japanese Circulation So
- Which is most Beneficial for Preserving Cardiac Function and Coronary Microvasculaturein DCM, ACE-I, ARB or Two in Combination? (Cardiac Hypertrophy/Cardiomyopathy 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Eplerenone Prevents Cardiac Fibrosis through the Inhibition of OPN Expression (Cardiac Hypertrophy, Basic (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Osteopontin is Essential for Angiotensin II-Induced Cardiac Fibrosis(Heart Failure, Basic 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Angiotensin II Receptor Blocker, Valsartan, Increases Myocardial Blood Volume and Regresses Hypertrophy in Hypertensive Patients
- Effects of Atrial Fibrillation on Long-Term Outcomes in Patients Hospitalized for Heart Failure in Japan : A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)
- Anemia is an Independent Predictor of Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan : A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)
- Characteristics and Outcomes of Hospitalized Patients With Heart Failure and Reduced vs Preserved Ejection Fraction : A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)
- Chronic Kidney Disease as an Independent Risk for Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan : Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)
- 6 Long-term Outcomes of Patients with Preserved Systolic Function Hospitalized for Heart Failure : an Analysis from JCARE-CARD(Pathophysiology and Therapeutic Strategy of Diastolic Dysfunction in Heart Failure,Plenary Session 4 (PL-4) (IHD),The 73rd Annua
- PJ-907 Oxydative Stress Impairs Mitochondrial Respiration in Skeletal Muscle and Limits Exercise Capacity in Diabetic Mice(Metabolism / Biochemistry / Energetics(03)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulatio
- OJ-095 Impairment of insulin signaling by oxidative stress in skeletal muscle causes insulin resistance in mice with heart failure.(Heart failure, basic(02)(M),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soci
- OE-372 Angiotensin II-induced Oxidative Stress Impairs Mitochondrial Energy Metabolism in Lower Extremity Skeletal Muscle and Limits Exercise Capacity in Mice(Neurohumoral factors(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the
- Angiotensin II Type 1 Receptor Blocker Attenuates Myocardial Remodeling and Preserves Diastolic Function in Diabetic Heart
- PJ-120 Exercise Capacity is Limited in Diabetic Mice due to the Impairment of Aerobic Oxidative Capacity in Skeletal Muscle(Metabolism/Biochemistry/Energetics-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 6 Long-term Outcomes of Patients with Preserved Systolic Function Hospitalized for Heart Failure : an Analysis from JCARE-CARD(Pathophysiology and Therapeutic Strategy of Diastolic Dysfunction in Heart Failure,Plenary Session 4 (PL-4) (IHD),The 73rd Annua
- PJ-907 Oxydative Stress Impairs Mitochondrial Respiration in Skeletal Muscle and Limits Exercise Capacity in Diabetic Mice(Metabolism / Biochemistry / Energetics(03)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulatio
- OJ-095 Impairment of insulin signaling by oxidative stress in skeletal muscle causes insulin resistance in mice with heart failure.(Heart failure, basic(02)(M),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soci
- OE-372 Angiotensin II-induced Oxidative Stress Impairs Mitochondrial Energy Metabolism in Lower Extremity Skeletal Muscle and Limits Exercise Capacity in Mice(Neurohumoral factors(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the
- 6 Long-term Outcomes of Patients with Preserved Systolic Function Hospitalized for Heart Failure : an Analysis from JCARE-CARD(Pathophysiology and Therapeutic Strategy of Diastolic Dysfunction in Heart Failure,Plenary Session 4 (PL-4) (IHD),The 73rd Annua
- PJ-907 Oxydative Stress Impairs Mitochondrial Respiration in Skeletal Muscle and Limits Exercise Capacity in Diabetic Mice(Metabolism / Biochemistry / Energetics(03)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulatio
- OJ-095 Impairment of insulin signaling by oxidative stress in skeletal muscle causes insulin resistance in mice with heart failure.(Heart failure, basic(02)(M),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soci
- OE-372 Angiotensin II-induced Oxidative Stress Impairs Mitochondrial Energy Metabolism in Lower Extremity Skeletal Muscle and Limits Exercise Capacity in Mice(Neurohumoral factors(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the
- 6 Long-term Outcomes of Patients with Preserved Systolic Function Hospitalized for Heart Failure : an Analysis from JCARE-CARD(Pathophysiology and Therapeutic Strategy of Diastolic Dysfunction in Heart Failure,Plenary Session 4 (PL-4) (IHD),The 73rd Annua
- PJ-907 Oxydative Stress Impairs Mitochondrial Respiration in Skeletal Muscle and Limits Exercise Capacity in Diabetic Mice(Metabolism / Biochemistry / Energetics(03)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulatio
- OJ-095 Impairment of insulin signaling by oxidative stress in skeletal muscle causes insulin resistance in mice with heart failure.(Heart failure, basic(02)(M),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soci
- OE-372 Angiotensin II-induced Oxidative Stress Impairs Mitochondrial Energy Metabolism in Lower Extremity Skeletal Muscle and Limits Exercise Capacity in Mice(Neurohumoral factors(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the
- OE-084 Surgical Ventricular Reconstruction Improves Myocardial Oxidative Efficiency Assessed by ^ C-acetate PET and Echocardiography in Patients with Severe Heart Failure(OE15,Cardiac Function (Clinical) (M),Oral Presentation (English),The 73rd Annual
- Low Peripheral Lymphocyte Count Before Focal Radiotherapy Plus Concomitant Temozolomide Predicts Severe Lymphopenia During Malignant Glioma Treatment
- Effects of Single Administration of a Phosphodiesterase III Inhibitor During Cardiopulmonary Bypass : Comparison of Milrinone and Amrinone
- Effect of Post-Processing Treatments on Improvement of the Taste of Silicone Rubber for Beverage Use
- Meningioma Associated With Werner Syndrome
- "Geological survey in southern to eastern peninsular India, 1996"
- Quantification of Retinal Nerve Fiber Defects in Glaucoma : Three-Dimensional Analysis by Heidelberg Retina Tomograph
- Prevalence of Normal-Tension Glaucoma and Primary Open-Angle Glaucoma in Patients With Collagen Diseases
- Asymmetric 1,4-Addition Reaction of Arylboronic Acid to Eneone Catalyzed by Palladium with Ferrocene-based Phosphine Ligand
- Palladium Catalyzed Conjugate 1,4-Addition of Organoboronic Acids to α,β-Unsaturated Ketones
- Clinical trial of autologous formalin-fixed tumor vaccine for glioblastoma multiforme patients
- Slow and Fast MHD Shocks Associated with a Giant Cusp-Shaped Arcade on 1992 January 24
- Simple New Method for Making a Rat Carotid Artery Post-angioplasty Stenosis Model
- A New System to Supply Carbon Dioxide Safely to Glaucoma Patients
- Allopurinol Improves Cardiac Dysfunction After Ischemia-Reperfusion via Reduction of Oxidative Stress in Isolated Perfused Rat Hearts
- Results from Coronary Artery Bypass Surgery Combined Abdominal Aortic Aneurysm Repair
- Mn-Metalloporphyrin Conjugated with Gd-DTPA (Gd-ATN10): Tumor Enhancement Agent for Magnetic Resonance Imaging
- Diurnal Variation of Intraocular Pressure in Suspected Normal-Tension Glaucoma
- Surface Plasmon Excitation and Emitted Light Properties in Otto/Kretschmann Configuration
- Long-term Therapeutic Outcome of Acute Primary Angle Closure in Japanese
- Design of Radial Line Slot Antennas at 8.3 GHz for Large Area Uniform Plasma Generation
- Particle size measurement of standard reference particle candidates and theoretical estimation of uncertainty region
- Nucleation and Growth Process of Polystyrene Particle Investigated by AFM
- AFM Observation of Growing Poly Isobutyl Methacrylate (PiBMA) Particles
- Origin of the apparent long-range attractive force between surfaces in cyclohexane
- JTII-41 Cytological features of malignant Brenner tumor of the ovary in ascitic fluid
- Correlation Between Individual Differences in Intraocular Pressure Reduction and Outflow Facility Due to Latanoprost in Normal-Tension Glaucoma Patients
- Neuroprotective Effects of R(-)-1-(benzo[b]thiophen-5-yl)-2-[2-(N, N-diethylamino)ethoxy]Ethanol Hydrochloride (T-588) Against Retinal Ganglion Cell Death Induced by Elevated Intraocular Pressure in Rat
- Adsorption Properties of Metal Ions onto Sodium Polyacrylate Gel
- ADSORPTION PROPERTIES OF TRIVALENT METAL IONS ONTO HYDROLYZED POLYACRYLAMIDE GEL
- A Novel Approach to the Prevention of Postoperative Delirium in the Elderly After Gastrointestinal Surgery
- Joint Frequency-Domain Equalization and Despreading for Multi-Code DS-CDMA Using Cyclic Delay Transmit Diversity
- "Migmatite and Granulites in the patapatnam-Tekkali area, Eastern Ghats, India"
- Cataract Development After Trabeculectomy With Mitomycin C : A 1-Year Study
- Effect of Trabeculectomy on Visual Field in Progressive Normal-Tension Glaucoma
- Enhancement of apoptotic damage of squamous cell carcinoma cells by inhibition of the mitochondrial DNA repairing system
- Reactive oxygen species (ROS) control the expression of Bcl-2 family proteins by regulating their phosphorylation and ubiquitination
- The Upregulation by Peplomycin of Signal Transduction in Human Cells
- Manganese Superoxide Dismutase Negatively Regulates the Induction of Apoptosis by 5-Fluorouracil, Peplomycin and γ-Rays in Squamous Cell Carcinoma Cells
- Expression of p53 and p21 Proteins in Oral Squamous Cell Carcinoma : Correlation with Lymph Node Metastasis and Response to Chemoradiotherapy
- Suppression by Azelastine Hydrochloride of NF : kB Activation Involved in Generation of Cytokines and Nitric Oxide
- Combination Adoptive Immunotherapy with Chemoradiotherapy in Oral Carcinomas
- Effect of Mitomycin C Dissolved in Reversible Thermo-Setting Gel on the Outcome of Filtering Surgery in the Rabbit
- Near-Field Distribution of Radial Line Slot Antenna for Surface-Wave-Coupled Plasma Generation
- Production of Large-Diameter Uniform Plasma in mTorr Range Using Microwave Discharge
- -P144- STUDIES ON CARDIAC SYMPATHETIC NERVE INVOLVEMENT IN THE PATIENTS WITH DIABETES MELLITUS : CORRELATION BETWEEN ^I-MIBG SPECT FINDINGS AND POWERSPECTRAL ANALYSIS OF THE HEART RATE VARIABILITY(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF
- Agreement Between Peripheral Anterior Chamber Depth Evaluation Using the van Herick Technique and Angle Width Evaluation Using the Shaffer System in Japanese
- Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion : Evaluation by Diffusion Tensor Imaging : Three Case Reports
- Target Intraocular Pressure for Stability of Visual Field Loss Progression in Normal-Tension Glaucoma
- Amino Acid Exchange Reaction of Bis(pyridoxylidene-amino acidato)cobalt(III) Complex Promoted by the α-Hydroxylation
- A Novel Transamination Induced by Terpyridine Ligand Coordinated on Cobalt(III) Ion
- A New Transformation, α-Hydroxylation, of Pyridoxylidene-Amino Acid Mediated on Co(III) Complex
- Role of Cl or I Codoping in Li-Doping Enhancement in ZnSe
- Influence of Antioxidative Hindered Phenols on the Taste of Beverages in the Presence of Free Chlorine
- Frequency-Domain Block Signal Detection for Single-Carrier Transmission
- A Full-Wave Analysis of a Complete Model for a Radial Line Slot Antenna
- A prospective analysis of anti-desmoglein antibody profiles in patients with rheumatoid arthritis treated with thiol compounds
- Topographic Characteristics of the Optic Nerve Head Measured with Scanning Laser Tomography in Normal Japanese Subjects
- Temporal Modulation Transfer Function in Normal-Tension Glaucoma Patients
- Effects of Corneal Thickness on Intraocular Pressure Measured with Three Different Tonometers
- Decreased Nasal-Temporal Asymmetry of the Second-Order Kernel Response of Multifocal Electroretinograms in Eyes with Normal-Tension Glaucoma
- Efficacy of Keishibukuryogan, a Traditional Japanese Herbal Medicine, in Treating Cold Sensation and Numbness After Stroke : Clinical Improvement and Skin Temperature Normalization in 22 Stroke Patients
- Migraine impact reduction with decreased cutaneous electroconductivity after administration of Japanese herbal medicine goshuyuto : two case reports
- Superior Segmental Optic Hypoplasia Found in Tajimi Eye Health Care Project Participants
- Pathological Changes After Autologous Formalin-Fixed Tumor Vaccine Therapy Combined With Temozolomide for Glioblastoma : Three Case Reports
- Effects of graded load of artificial gravity on vestibulospinal and vestibulo-ocular functions
- Combined Transmastoid/Middle Fossa Approach for Intracranial Extension of Middle Ear Cholesteatoma