EFFECTS ON ATRIO-VENTRICULAR CONDUCTION OF PROPRANOLOL, PINDOLOL AND CARTEOLOL IN THE DOG HEART <I>IN SITU</I> AS ASSESSED BY AUTOMATED DEVICES
スポンサーリンク
概要
- 論文の詳細を見る
In open-chest dogs the heart rate was controlled at 150 beats/min and drugs were given intravenously. Propranolol (30 μg/kg-1 mg/kg) prolonged the atrio-ventricular (A-V) conduction time and functional refractory period of the A-V conduction system (FRP) by blockade of the existing tone of the sympathetic nerves to the heart. The prolongation of the two parameters by the non-specific depressant action of propranolol was evident only at 3 mg/kg. Propranolol (3-30 μg/kg) shortened the A-V conduction time in the heart deprived of the vagal and sympathetic tone, suggesting some sort of sympathomimetic effect. Pindolol in a wide range of doses (0.3-300 μg/kg) exerted virtually no effect on the A-V conduction time and FRP, and its non-specific depressant action was apparent only at 3 mg/kg. Carteolol slightly prolonged the A-V conduction time and FRP only in low doses (1-10 μg/kg), and in high doses (30 μg/kg-1 mg/kg) it shortened the two parameters, reflecting its predominant sympathomimetic action.
- 社団法人 日本薬理学会の論文
著者
-
Satoh Keisuke
Department Of Pathophysiological And Therapeutic Science Division Of Molecular Pharmacology Tottori
-
Yanagisawa Teruyuki
Department Of Molecular Pharmacology Tohoku University Graduate School Of Medicine
-
Taira Norio
Department Of Pharmacology Tohoku University School Of Medicine
-
Iijima Toshihiko
Department Of Life And Medicine Urayasu Hospital Of Juntendo University School Of Medicine
-
NARIMATSU Akihiro
Department of Pharmacology, Tohoku University School of Medicine
-
Satoh Keisuke
Department of Pharmacology, Tohoku University School of Medicine
-
IIJIMA Toshihiko
Department of Pharmacology, Tohoku University School of Medicine
-
TAIRA Norio
Department o f Pharmacology, Tohoku University, School of Medicine
関連論文
- On the Inotropic Actions of Arginine Vasopressin in Ventricular Muscle of the Guinea Pig Heart
- -384-THE EFFECTS OF NICORANDIL AND CROMAKALIM (POTASSIUM CHANNEL OPENERS) ON VENOUS RETURN IN THE DOG : Cardiovascular Drugs : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- A/C^ Gene Polymorphism of the Angiotensin II Type 1 Receptor (AT1) and Ambulatory Blood Pressure : the Ohasama Study
- Analgesic action of loperamide, an opioid agonist, and its blocking action on voltage-dependent Ca^ channels
- EFFECTS OF T-1583 AND ISOPROTERENOL ON MYOCARDIAL CONTRACTILITY AND OXYGEN CONSUMPTION IN ISOLATED BLOOD-PERFUSED CANINE WHOLE HEART PREPARATIONS : Cardiovascular Drugs : 53 Annual Scientific Meeting, Japanese Circulation Society
- Vascular endothelial growth factor broadens lentivector distribution in the heart after neonatal injection
- Modulation by Mibefradil of the Histamine-Induced Ca^ Entry in Human Aortic Endothelial Cells
- Pathophysiological Significance of T-type Ca^ Channels : Properties and Functional Roles of T-type Ca^ Channels in Cardiac Pacemaking
- Sevoflurane Inhibition of the Slowly Activating Delayed Rectifier K^+ Current in Guinea Pig Ventricular Cells
- Pacemaker Mechanism of Porcine Sino-atrial Node Cells(PACEMAKER CELLS IN THE HEART AND GUT)
- Cloning and Functional Expression of a Novel Splice Variant of Rat TRPC4
- Cloning and Functional Expression of a Novel Splice Variant of Rat TRPC4
- Similarity and Dissimilarity in Mode and Mechanism of Action between YT-146, a Selective Adenosine Receptor A_2 Agonist, and Adenosine in Isolated Canine Hearts
- Recent Advances in Molecular Pharmacology of the Histamine Systems : Roles of C-terminal Tails of Histamine Receptors
- Improvement by Trapidil of Cardiac Function of the Dog Heart-lung Preparation Depressed by Pentobarbital
- DIFFERENTIAL EFFECTS OF NITROGLYCERIN, TRIMETAZIDINE, VERAPAMIL AND SK&F 24260 ON VENOUS RETURN AS REVEALED BY THE OPEN-LOOP METHOD IN THE DOG
- CHARACTERIZATION OF β-ADRENOCEPTORS IN THE DOG SAPHENOUS VEIN
- SIMULTANEOUS ASSESSMENT OF EFFECTS OF CORONARY VASODILATORS ON THE CORONARY BLOOD FLOW AND THE MYOCARDIAL CONTRACTILITY BY USING THE BLOOD-PERFUSED CANINE PAPILLARY MUSCLE
- DUAL EFFECTS OF A NEW CORONARY VASODILATOR, DILTIAZEM, ON THE CONTRACTILE FORCE OF THE BLOOD-PERFUSED PAPILLARY MUSCLE OF THE DOG
- The Improvement of Cardiac Performance by Amrinone, a New Cardiotonic Drug, in an Experimental Failing Heart Preparation of the Dog
- DIFFERENTIAL EFFECTS OF D 600 ON RELEASE OF CATECHOLAMINES BY ACETYLCHOLINE, HISTAMINE, TYRAMINE AND BY CYCLIC AMP FROM CANINE ADRENAL MEDULLA
- Cardiohemodynamic Effects of SK&F 24260, D 600, Diltiazem, Dilazep, and Trimetazidine in the Dog
- Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity : An experimental rat model
- Urodynamic effects and safety of modified intravesical oxybutynin chloride in patients with neurogenic detrusor overactivity : 3 years experience
- EFFECTS OF AMRINONE ON THE TRACHEAL MUSCULATURE AND VASCULATURE OF THE DOG
- THE EXPERIMENTAL MODEL OF CORONARY VASOSPASM IN THE MONKEY : Coronary Circulation : 46th Annual Scientific Meeting, Japanese Circulation Society
- CIRCUMSTANTIAL EVIDENCE FOR INCREASED POTASSIUM CONDUCTANCE OF MEMBRANE OF CARDIAC MUSCLE BY 2-NICOTINAMIDOETHYL NITRATE (SG-75)
- PJ-576 Arrhythmogenic Effect of Endothelin by Differential Inhibition of Transient Outward Currents of Kv1.4 and Kv4.3(Arrhythmia, Basic and Diagnosis/Pathophysiology/EPS (A) : PJ96)(Poster Session (Japanese))
- IS THE INCREASED K CONDUCTANCE IN CELL MEMBRANE RESPONSIBLE FOR THE INHIBITORY EFFECT OF ACETYLCHOLINE ON ATRIOVENTRICULAR CONDUCTION? : Antiarrhythmic Drugs : IV Auditorium : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION S
- ABSENCE OF A NEURALLY-MEDIATED PROCESS IN SALIVATION AND VASODILATION CAUSED BY McN-A-343 IN THE DOG SUBMAXILLARY GLAND
- EFFECTS OF ANISOTROPINE METHYLBROMIDE (VALPIN®) AND ITS MIXTURE WITH SULPYRINE ON VOCALIZATION RESPONSE AND SPASM OF INTESTINE INDUCED BY ACETYLCHOLINE IN DOGS
- Efficacy of Metformin in Non-Obese Type 2 Diabetic Patients with Secondary Failure to Sulfonylurea Therapy
- DECREASES IN ARTERIAL PRESSURE AND HEART RATE ELICITED BY ELECTRICAL STIMULATION OF THE ANTERIOR HYPOTHALAMUS OF PENTOBARBITAL ANESTHETIZED DOGS
- DEPRESSION BY CARBACHOL OF CALCIUM-DEPENDENT ACTION POTENTIALS IN THE CANINE VENTRICULAR MUSCLE DEPOLARIZED BY POTASSIUM
- Cardiohemodynamic Effects of Nitroglycerin and Several Vasodilators
- EFFECTS ON ATRIO-VENTRICULAR CONDUCTION OF PROPRANOLOL, PINDOLOL AND CARTEOLOL IN THE DOG HEART IN SITU AS ASSESSED BY AUTOMATED DEVICES
- Potentiation of the algogenic action of bradykinin by an inhibitor of angiotensin I converting enzyme, captopril (SQ 14,225).
- PHARMACOLOGICAL FEATURES OF PERIPHERAL VASCULAR BEDS OF BEAGLES
- Interaction of PICK1 with C-Terminus of Growth Hormone–Releasing Hormone Receptor (GHRHR) Modulates Trafficking and Signal Transduction of Human GHRHR
- Effect of 2-nicotinamidethyl nitrate (SG-75) on membrane potentials of canine Purkinje fibers.
- Improvement of pentobarbital-induced heart failure by MCI-154, a novel and potent cardiotonic agent, in the dog heart-lung preparation.
- ATP-Sensitive K+ Channels Are Gradually Recruited in the Vasodepressor Response to Adenosine in Spinally-Anesthetized Dogs.
- Improvement of Cardiac Performance by Pimobendan, a New Cardiotonic Drug, in the Experimental Failing Dog Heart.
- Comparison of the cardiovascular and biochemical profiles of a new positive inotropic drug, AR-L 115 BS, with those of theophylline.
- Cardiac versus coronary vasodilator actions of isobutylmethylxanthine in dogs: Comparison with theophylline.
- Differential effects of isoproterenol on the canine atrial action potential in the presence of carbachol or nicorandil.
- Involvement of cyclic AMP in the positive inotropic effect of OPC-8212, a new cardiotonic agent, on the canine ventricular muscle.
- Voltage- and use-dependent block of the inward calcium current by MCI-176, a new non-dihydropyridine calcium antagonist, in canine ventricular muscles and single ventricular cells of the guinea-pig.
- Amelioration of heart failure by MDL 17043 and MDL 19205, novel positive inotropic drugs, in dog heart-lung preparations.
- Relaxation of airway smooth muscle induced by potassium in the presence of Ca-antagonists.
- IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses
- Improvement of cardiac performance by AR-L 115 BS, a new cardiotonic drug, in the experimental failing dog heart.
- Specific antagonism by glibenclamide of negative inotropic effects of potassium channel openers in canine atrial muscle.
- Cardiohemodynamic effects of nipradilol (K-351) in the dog: Comparison with propranolol, nadolol and prazosin.
- Are the cardiovascular effects of gentamicin similar to those of calcium antagonists?
- Effects of Semotiadil (SD-3211), a Benzothiazine Calcium Antagonist, on Blood Pressure and Atrioventricular Conductivity in Anesthetized Dogs.
- Nicorandil releases acetylcholine-induced sustained coronary arterial constriction in monkeys and baboons.
- Sevoflurane Inhibition of the Slowly Activating Delayed Rectifier K+ Current in Guinea Pig Ventricular Cells
- A Possibility That the ATP-Sensitive Potassium Channel in Coronary Artery Has a High-Affinity Internal Binding Site for Tetraalkylammonium.
- Changes in membrane potentials and currents of ventricular cells of the guinea pig heart by a new cardiotonic drug, MCI-154.
- Effect of adenine on twitch and other contractile responses of single fibers of amphibian fast skeletal muscle.
- Postnatal Changes in mRNA Expression of the K+ Channel in Rat Cardiac Ventricles.
- Interaction of PICK1 with C-Terminus of Growth Hormone-Releasing Hormone Receptor (GHRHR) Modulates Trafficking and Signal Transduction of Human GHRHR