ATP-Sensitive K+ Channels Are Gradually Recruited in the Vasodepressor Response to Adenosine in Spinally-Anesthetized Dogs.
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概要
- 論文の詳細を見る
Vasodepressor mechanisms of adenosine were investigated in spinally-anesthetized dogs. An i.v.-infusion of adenosine (0.1-10 μmol/kg/min) caused a slowly developing and sustained decrease in blood pressure (BP). This vasodepression was antagonized by glibenclamide, a blocker of ATP-sensitive K<SUP>+</SUP> (K<SUB>ATP</SUB>) channels. On the other hand, a transient decrease in BP caused by a single bolus i.v.-injection of adenosine was not antagonized by glibenclamide in our previous study. These results suggested that the opening of K<SUB>ATP</SUB> channels is gradually recruited in the vasodepressor mechanisms for adenosine-induced sustained vasodepression.
- 公益社団法人 日本薬理学会の論文
著者
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Orito Kensuke
Department of Physiology II, School of Veterinary Medicine, Azabu University
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Satoh Keisuke
Department Of Pathophysiological And Therapeutic Science Division Of Molecular Pharmacology Tottori
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TAIRA Norio
Department o f Pharmacology, Tohoku University, School of Medicine
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