A Sensitive Gait Parameter for Quantification of Arthritis in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Quantification of arthritis is helpful for investigating pain mechanisms of arthritis and for developing new drugs. We assessed and identified a feasible parameter for quantification of rat arthritis using a novel gait analyzing system. Knee-joint injection with small doses of λ-carrageenan decreased swing time ratio (STR, swing time of the non-treated hindlimb/swing time of the λ-carrageenan-injected hindlimb) in a dose-dependent manner. Intraperitoneal treatment with indomethacin restored the decreased STR dose-dependently. The arthritis could not be accurately quantified by swing time and swelling, common indices of arthritis. These results show that STR is a sensitive, reliable parameter for quantification of arthritis.
- 社団法人 日本薬理学会の論文
- 2007-01-20
著者
-
Orito Kensuke
Department of Physiology II, School of Veterinary Medicine, Azabu University
-
TANAKA Akane
Laboratory of Veterinary Molecular Pathology and Therapeutics, Graduate School, Institute of Symbiot
-
MATSUDA Hiroshi
Laboratory of Veterinary Molecular Pathology and Therapeutics, Graduate School, Institute of Symbiot
-
Orito Kensuke
Department Of Veterinary Pharmacology Azabu University School Of Veterinary Medicine
-
Sawada Junko
Laboratory Of Veterinary Molecular Pathology And Therapeutics Division Of Animal Life Science Gradua
-
Tanaka Akane
Lab. Of Veterinary Molecular Pathology And Therapeutics Graduate School Inst. Of Symbiotic Sci. And
-
Tanaka Akane
Laboratory Of Veterinary Molecular Pathology And Therapeutics Graduate School Institute Of Symbiotic
-
KUROZUMI Shogo
Department of Artificial Complex Systems Engineering, Graduate School of Engineering, Hiroshima Univ
-
ISHII Idaku
Department of Artificial Complex Systems Engineering, Graduate School of Engineering, Hiroshima Univ
-
Ishii Idaku
Department Of Artificial Complex Systems Engineering Graduate School Of Engineering Hiroshima Univer
-
Kurozumi Shogo
Department Of Artificial Complex Systems Engineering Graduate School Of Engineering Hiroshima Univer
-
Matsuda Hiroshi
Laboratory Of Veterinary Molecular Pathology And Therapeutics Division Of Animal Life Science Gradua
-
Tanaka Akane
Laboratory Of Veterinary Molecular Pathology And Therapeutics Division Of Animal Life Science Institute Of Agriculture Tokyo University Of Agriculture And Technology
-
Matsuda Hiroshi
Laboratory Of Clinical Immunology Department Of Veterinary Medicine Faculty Of Agriculture Tokyo University Of Agriculture And Technology
-
TANAKA Akane
Laboratory of Clinical Immunology, Department of Veterinary Clinic, Faculty of Agriculture, Tokyo University of Agriculture and Technology
-
Orito Kensuke
Department of Pharmacology, Tohoku University School of Medicine
-
ORITO Kensuke
Department of Pharmacology, Azabu University School of Veterinary Medicine
関連論文
- Therapeutic Time Window of Cannabidiol Treatment on Delayed Ischemic Damage via High-Mobility Group Box1-Inhibiting Mechanism
- Neuroprotective Effects of Quercetin and Rutin on Spatial Memory Impairment in an 8-Arm Radial Maze Task and Neuronal Death Induced by Repeated Cerebral Ischemia in Rats
- Effect of NGF on the Motility and Acrosome Reaction of Golden Hamster Spermatozoa In Vitro
- Moment feature-based three-dimensional tracking using two high-speed vision systems
- Cardiac Remodeling and Angiotensin II-Forming Enzyme Activity of the Left Ventricle in Hamsters with Chronic Pressure Overload Induced by Ascending Aortic Stenosis
- Effect of Angiotensin II Type 1 Receptor Blocker on Cardiac Angiotensin-Converting Enzyme and Chymase-Like Activities, and Cardiac Fibrosis in Cardiomyopathic Hamsters
- Chymase is Activated in the Pulmonary Inflammation and Fibrosis Induced by Paraquat in Hamsters
- Suplatast Tosilate Inhibits Human Mast Cell Development from Cord Blood Progenitors
- Prenatal Exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126) Promotes Anxiogenic Behavior in Rats
- Epsilon-Polylysine Microparticle Adjuvant Drives Cytokine Production to Th1 Profile
- A Sensitive Gait Parameter for Quantification of Arthritis in Rats
- P10-04 Changes Detected in Plasma Antiproteases in Paraquat Poisoned Rats Using Micro Two-Dimensional Electrophoretic Analysis
- Behavior abnormalities in rat offspring prenatally exposed to 5-bromo-2'-deoxyuridine (NEREVOUS SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Manipulation by a multifingered hand using high-speed visual feedback
- General-purpose vision chip architecture for real-time machine vision
- Cross-Reactivity of Japanese Encephalitis Virus-Vaccinated Horse Sera in Serodiagnosis of West Nile Virus
- ヒトアトピー性皮膚炎モデルマウスに関する最近の知見
- A Fast Multi-Object Extraction Algorithm Based on Cell-Based Connected Components Labeling
- ATP-Sensitive K+ Channels Are Gradually Recruited in the Vasodepressor Response to Adenosine in Spinally-Anesthetized Dogs.
- Atopic NC/Nga Mice as a Model for Allergic Asthma: Severe Allergic Responses by Single Intranasal Challenge with Protein Antigen.
- A Possibility That the ATP-Sensitive Potassium Channel in Coronary Artery Has a High-Affinity Internal Binding Site for Tetraalkylammonium.