Improvement of Cardiac Performance by Pimobendan, a New Cardiotonic Drug, in the Experimental Failing Dog Heart.
スポンサーリンク
概要
- 論文の詳細を見る
The cardiotonic effect of pimobendan was studied in 6 dog heart-lung preparations in which cardiac function had been severely depressed by pentobarbital. Pimobendan in doses of 1-10mg improved cardiac function in a dose-dependent manner and at 10mg improved it beyond the control. These doses of pimobendan, however, produced neither a significant increase in heart rate nor arrhythmias. The results indicate that the drug may be of use in the treatment of heart failure.
- International Heart Journal刊行会の論文
著者
-
Satoh Keisuke
Department Of Pathophysiological And Therapeutic Science Division Of Molecular Pharmacology Tottori
-
Satoh Yoshinori
Department Of Microbiology And Parasitology Kitasato University School Of Medicine
-
TAIRA Norio
Department o f Pharmacology, Tohoku University, School of Medicine
-
IMAGAWA Jun-ichi
Department of Pharmacology, Tohoku University School of Medicine
-
SATOH Yoshinori
Department of Pharmacology, Tohoku University School of Medicine
関連論文
- Pretreatment of Pseudomonas aeruginosa with a sub-MIC of imipenem enhances bactericidal activity of neutrophils
- -384-THE EFFECTS OF NICORANDIL AND CROMAKALIM (POTASSIUM CHANNEL OPENERS) ON VENOUS RETURN IN THE DOG : Cardiovascular Drugs : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- EFFECTS OF T-1583 AND ISOPROTERENOL ON MYOCARDIAL CONTRACTILITY AND OXYGEN CONSUMPTION IN ISOLATED BLOOD-PERFUSED CANINE WHOLE HEART PREPARATIONS : Cardiovascular Drugs : 53 Annual Scientific Meeting, Japanese Circulation Society
- Apoptosis of intestinal crypt epithelium after Cryptosporidium parvum infection
- Similarity and Dissimilarity in Mode and Mechanism of Action between YT-146, a Selective Adenosine Receptor A_2 Agonist, and Adenosine in Isolated Canine Hearts
- Improvement by Trapidil of Cardiac Function of the Dog Heart-lung Preparation Depressed by Pentobarbital
- DIFFERENTIAL EFFECTS OF NITROGLYCERIN, TRIMETAZIDINE, VERAPAMIL AND SK&F 24260 ON VENOUS RETURN AS REVEALED BY THE OPEN-LOOP METHOD IN THE DOG
- CHARACTERIZATION OF β-ADRENOCEPTORS IN THE DOG SAPHENOUS VEIN
- SIMULTANEOUS ASSESSMENT OF EFFECTS OF CORONARY VASODILATORS ON THE CORONARY BLOOD FLOW AND THE MYOCARDIAL CONTRACTILITY BY USING THE BLOOD-PERFUSED CANINE PAPILLARY MUSCLE
- DUAL EFFECTS OF A NEW CORONARY VASODILATOR, DILTIAZEM, ON THE CONTRACTILE FORCE OF THE BLOOD-PERFUSED PAPILLARY MUSCLE OF THE DOG
- The Improvement of Cardiac Performance by Amrinone, a New Cardiotonic Drug, in an Experimental Failing Heart Preparation of the Dog
- Cardiohemodynamic Effects of SK&F 24260, D 600, Diltiazem, Dilazep, and Trimetazidine in the Dog
- Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity : An experimental rat model
- Urodynamic effects and safety of modified intravesical oxybutynin chloride in patients with neurogenic detrusor overactivity : 3 years experience
- EFFECTS OF AMRINONE ON THE TRACHEAL MUSCULATURE AND VASCULATURE OF THE DOG
- THE EXPERIMENTAL MODEL OF CORONARY VASOSPASM IN THE MONKEY : Coronary Circulation : 46th Annual Scientific Meeting, Japanese Circulation Society
- CIRCUMSTANTIAL EVIDENCE FOR INCREASED POTASSIUM CONDUCTANCE OF MEMBRANE OF CARDIAC MUSCLE BY 2-NICOTINAMIDOETHYL NITRATE (SG-75)
- EFFECTS OF ANISOTROPINE METHYLBROMIDE (VALPIN®) AND ITS MIXTURE WITH SULPYRINE ON VOCALIZATION RESPONSE AND SPASM OF INTESTINE INDUCED BY ACETYLCHOLINE IN DOGS
- Cardiohemodynamic Effects of Nitroglycerin and Several Vasodilators
- EFFECTS ON ATRIO-VENTRICULAR CONDUCTION OF PROPRANOLOL, PINDOLOL AND CARTEOLOL IN THE DOG HEART IN SITU AS ASSESSED BY AUTOMATED DEVICES
- Potentiation of the algogenic action of bradykinin by an inhibitor of angiotensin I converting enzyme, captopril (SQ 14,225).
- PHARMACOLOGICAL FEATURES OF PERIPHERAL VASCULAR BEDS OF BEAGLES
- Effect of 2-nicotinamidethyl nitrate (SG-75) on membrane potentials of canine Purkinje fibers.
- Improvement of pentobarbital-induced heart failure by MCI-154, a novel and potent cardiotonic agent, in the dog heart-lung preparation.
- ATP-Sensitive K+ Channels Are Gradually Recruited in the Vasodepressor Response to Adenosine in Spinally-Anesthetized Dogs.
- Improvement of Cardiac Performance by Pimobendan, a New Cardiotonic Drug, in the Experimental Failing Dog Heart.
- Comparison of the cardiovascular and biochemical profiles of a new positive inotropic drug, AR-L 115 BS, with those of theophylline.
- Cardiac versus coronary vasodilator actions of isobutylmethylxanthine in dogs: Comparison with theophylline.
- Differential effects of isoproterenol on the canine atrial action potential in the presence of carbachol or nicorandil.
- Involvement of cyclic AMP in the positive inotropic effect of OPC-8212, a new cardiotonic agent, on the canine ventricular muscle.
- Voltage- and use-dependent block of the inward calcium current by MCI-176, a new non-dihydropyridine calcium antagonist, in canine ventricular muscles and single ventricular cells of the guinea-pig.
- Amelioration of heart failure by MDL 17043 and MDL 19205, novel positive inotropic drugs, in dog heart-lung preparations.
- Relaxation of airway smooth muscle induced by potassium in the presence of Ca-antagonists.
- Improvement of cardiac performance by AR-L 115 BS, a new cardiotonic drug, in the experimental failing dog heart.
- Comparison of cardiovascular effects of SGB-1534 and prazosin, selective .ALPHA.1-adrenoceptor antagonists, in anesthetized dogs.
- Specific antagonism by glibenclamide of negative inotropic effects of potassium channel openers in canine atrial muscle.
- Cardiohemodynamic effects of nipradilol (K-351) in the dog: Comparison with propranolol, nadolol and prazosin.
- Are the cardiovascular effects of gentamicin similar to those of calcium antagonists?
- Effects of Semotiadil (SD-3211), a Benzothiazine Calcium Antagonist, on Blood Pressure and Atrioventricular Conductivity in Anesthetized Dogs.
- Nicorandil releases acetylcholine-induced sustained coronary arterial constriction in monkeys and baboons.
- A Possibility That the ATP-Sensitive Potassium Channel in Coronary Artery Has a High-Affinity Internal Binding Site for Tetraalkylammonium.
- Changes in membrane potentials and currents of ventricular cells of the guinea pig heart by a new cardiotonic drug, MCI-154.