The Na+-Ca2+ Exchanger Contributes to .BETA.-adrenoceptor Mediated Positive Inotropy in Mouse Heart.
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概要
- 論文の詳細を見る
The L-type Ca2+ current (ICa,L) plays an important role in the regulation of cardiac contractility. However, there is little data with regard to the significance of the ICa,L-independent mechanism of β-adrenoceptor mediated positive inotropy. The effects of isoproterenol (ISO) on ICa,L and contractility in the presence of Ca2+ channel blockers (nifedipine, verapamil) were examined in adult mouse ventricular myocytes. ISO increased contractility over the level before the administration of Ca2+ channel blocker, although it had a very limited effect on ICa,L. The positive inotropy of ISO disappeared after administration of Ni2+, an inhibitor of the Na+-Ca2+ exchanger. The addition of ISO after nifedipine pretreatment also increased the [Ca2+]i transient over the control level and the application of Ni2+ or KB-R7943, a selective Na+-Ca2+ exchange inhibitor (reverse mode), abolished the increase in [Ca2+]i transient. Therefore, an ICa,L-independent mechanism plays a significant role in β-adrenoceptor mediated positive inotropy. The Na+-Ca2+ exchanger is necessary for the development of this action.
- International Heart Journal刊行会の論文
著者
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Kubota Isao
First Department of Internal Medicine Yamagata University School of Medicine
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Tomoike Hitonobu
First Department Of Internal Medicine Yamagata University Medical School
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Endoh Masao
Department Of Cardiovascular Pharmacology Yamagata University School Of Medicine
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Sakurai Kiyoharu
Department of Cardiology, Tohoku Central Hospital of the Mutual Aid Association of Public School Teachers, Japan
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Han Xinquiang
Cardiovascular Division, Brigham and Women's Hospital
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Sakurai Kiyoharu
Department of Pharmacology, Yamagata University School of Medicine
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