Combination of Heart-Type Fatty Acid Binding Protein and Brain Natriuretic Peptide Can Reliably Risk Stratify Patients Hospitalized for Chronic Heart Failure

スポンサーリンク

概要

• 論文の詳細を見る

• Background The aim of the present study was to prospectively study whether a combination of markers for myocardial cell injury and left ventricular overload at admission can reliably risk stratify patients hospitalized for chronic heart failure (CHF). Methods and Results Serum concentrations of heart-type fatty acid binding protein (H-FABP) and plasma concentrations of brain natriuretic peptide (BNP) were measured at admission in 186 consecutive patients hospitalized for CHF. During a mean follow-up period of 534±350 days, there were 44 cardiac events, including 16 cardiac deaths and 28 readmissions for worsening heart failure. Normal upper limits for H-FABP and BNP values were determined from the receiver operating characteristic curves (4.3ng/ml for H-FABP and 200pg/ml for BNP). A stepwise Cox regression analysis demonstrated that high H-FABP (hazard ratio 5.416, p=0.0002) and high BNP (hazard ratio 2.411, p=0.0463) were independent predictors of cardiac events. High concentrations of both H-FABP and BNP at admission were associated with the highest incidence of cardiac mortality and cardiac events. Kaplan-Meier analysis also showed that the combination of H-FABP and BNP concentrations could reliably stratify patients for cardiac events. Conclusion Combined measurement of H-FABP and BNP concentrations at admission may be a highly reliable evaluation for risk stratifying patients hospitalized for CHF.

• 社団法人日本循環器学会の論文
• 2005-07-20

著者

• Takeishi Yasuchika

  First department of internal medicine, Fukushima Medical University

• FUKAO Akira

  Department of Public Health, Yamagata University School of Medicine

• Fukui A

  Department Of Internal Medicine Yamagata Prefectural Central Hospital

• TAKAHASHI Hiroki

  First Department of Internal Medicine, Sapporo Medical University, School of Medicine

• Fukui Akio

  Yamagata City Hospital Saiseikan

• Niizeki Takeshi

  First Department of Internal Medicine Yamagata University School of Medicine

• Arimoto Takanori

  First Department of Internal Medicine Yamagata University School of Medicine

• Takahashi Tatsuya

  Department of Diagnostic Information and Socioenvironmental Medicine, Yamagata University School of

• Okuyama Hidenobu

  First Department of Internal Medicine Yamagata University School of Medicine

• Takabatake Noriaki

  First Department of Internal Medicine Yamagata University School of Medicine

• Nozaki Naoki

  First Department of Internal Medicine Yamagata University School of Medicine

• Hirono Osamu

  First Department of Internal Medicine Yamagata University School of Medicine

• Tsunoda Yuichi

  First Department of Internal Medicine Yamagata University School of Medicine

• Shishido Tetsuro

  First Department of Internal Medicine Yamagata University School of Medicine

• Koyama Yo

  First Department of Internal Medicine Yamagata University School of Medicine

• Kubota Isao

  First Department of Internal Medicine Yamagata University School of Medicine

• Fukui Akio

  山形県立中央病院 内科循環器科

• Hirono O

  Department Of Cardiology Yamagata Prefectural Shinjo Hospital

• Hirono Osamu

  山形大学 循環･呼吸･腎臓内科

• Osamu Hirono

  山形大学 1内

• Hirono Osamu

  山形大学 医学部第1内科

• Koyama Yo

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Koyama Yo

  山形大学 医学部循環･呼吸･腎臓内科学

• Koyama Yo

  First Department Of Internal Medicine And Division Of Radiology Yamagata University School Of Medici

• Niizeki Takeshi

  First Department Of Internal Medicine And Division Of Radiology Yamagata University School Of Medici

• Nozaki Naoki

  山形大学 循環･呼吸･腎臓内科

• Nozaki Naoki

  First Department Of Internal Medicine Yamagata University Medical School

• Okuyama Hidenobu

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Okuyama Hidenobu

  山形大学 循環呼吸腎臓内科

• Okuyama Hidenobu

  First Department Of Internal Medicine And Division Of Radiology Yamagata University School Of Medici

• Takeishi Yasuchika

  First Department Of Internal Medicine Fukushima Medical University

• Tsunoda Yuichi

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Tsunoda Yuichi

  山形大学 循環器内科

• Tsunoda Yuichi

  山形大学 医学部第1内科

• Arimoto T

  Department Of Cardiology Pulmonary And Nephrology Yamagata University School Of Medicine

• Arimoto Takanori

  Departments Of Cardiology Ishinomaki Red Cross Hospital

• Shishido Tetsuro

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Shishido Tetsuro

  山形大学 医学部循環･呼吸･腎臓内科学

• Shishido Tetsuro

  山形大学 循環･呼吸･腎臓内科学

• Shishido Tetsuro

  The First Department Of Internal Medicine Yamagata University School Of Medicne

• Shishido Tetsuro

  First Department Of Internal Medicine And Division Of Radiology Yamagata University School Of Medici

• Takabatake Noriaki

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Takabatake Noriaki

  山形大学 医学部循環･呼吸･腎臓内科学

• Takabatake Noriaki

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Noriaki Takabatake

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Tamura Harutoshi

  山形大学 医学部循環･呼吸･腎臓内科学

• Araki Takao

  Department Of Cardiology Pulmonary And Nephrology Yamagata University School Of Medicine

• Fukui Akio

  Department Of Internal Medicine Yamagata Prefectural Central Hospital

• Fukao Akira

  Department Of Public Health Tohoku University School Of Medicine

• Takahashi Hiroki

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Fukui Akio

  1st Department Of Internal Medicine Yamagata University School Of Medicine

• Takahashi Hiroki

  First Department Of Internal Medicine Sapporo Medical University

• Funayama Akira

  Department Of Cardiology Pulmonary And Nephrology Yamagata University School Of Medicine

• Takahashi Tatsuya

  Department Of Clinical Neuropathology Tokyo Metropolitan Institute For Neuroscience

• Takahashi Tatsuya

  Department Of Applied Chemistry Yokohama National University

• Takahashi Hiroki

  First Department Of Internal Medicine Gunma University School Of Medicine

• Arimoto Takanori

  Division Of Cardiology Ishinomaki Red Cross Hospital

• Nozaki Naoki

  First Department Of Internal Medicine And Division Of Radiology Yamagata University School Of Medici

• Fukao Akira

  Department Of Public Health Graduate School Of Medical Science Yamagata University

関連論文

• OE-296 Metabolic Regulation of Coronary Vascular Tone : Role of Hydrogen Peroxide, Adenosine 5'-diphosphate, and Angiotensin(OE50,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Oral Presentation (English),The 73rd Annual Scientific M
• DPJ-072 Regulation of Coronary Vascular Tone via Redox Modulation in the Alpha1-Adrenergic-Angiotensin-Endothelin Axis of the Myocardium(DPJ12,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Digital Poster Session (Japanese),The 73rd
• Health Practices and Mortality in Japan : Combined Effects of Smoking, Drinking, Walking and Body Mass Index in the Miyagi Cohort Study
• Body Mass Index and Mortality in Japan : The Miyagi Cohort Study
• Walking and Mortality in Japan : The Miyagi Cohort Study
• Leukoencephalopathy during administration of etanercept for refractory rheumatoid arthritis
• A Case Control Study on the Effectiveness of Breast Cancer Screening by Clinical Breast Examination in Japan
• PE-361 Prognosis of Extremely Aged Patients (85 years and over) with Acute Myocardial Infarction(Acute myocardial infarction, clinical (diagnosis/treatment)(06)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation So
• PE-217 Altered Restitution Property of Activation Recovery Interval Predicts the Vulnerability of Ventricular Arrhythmia in Patients with Structural Heart Diseases(Arrhythmia, diagnosis/pathophysiology/EPS-9 (A) PE37,Poster Session (English),The 70th Anni
• Combination of Heart-Type Fatty Acid Binding Protein and Brain Natriuretic Peptide Can Reliably Risk Stratify Patients Hospitalized for Chronic Heart Failure
• The Increment of A-A Interval in Common Atrial Flutter Fluctuation Relates to Paroxysmal Atrial Fibrillation (ECG/Body Surface Potential Mapping/Holter 5 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Hyperuricemia is Associated with Cardiac Events in the Elderly CHF Patients(Heart Failure, Clinical 6 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• H-FABP is Associated with Cardiac Events in the Elderly CHF Patients(Cardiomyopathy, Clinical 6 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Serum Levels of Fibrin-monomer Directly Reflect the Left Atrial Appendage Flow Pattern Alterations and Predict the Occurrence of Cardioembolic Stroke(Cerebrovascular Circulation/Stroke 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation
• Serum Levels of Fibrin-monomer Reflect the Atheromatous Plaque Rupture in the Arch in Patients with Aortogenic Brain Embolism(Atherosclerosis, Clinical 9 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Prognostic Value of Heart-type Fatty Acid Binding Protein in Heart Failure Patients with Preserved Left Ventricular Systolic Function(Heart Failure, Clinical 7 (M) The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Risk Stratification Using a Combination of Heart-type Fatty Acid Binding Protein and Brain Natriuretic Peptide in Chronic Heart Failure Patients(Neurohumoral Factors 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Elevated Serum Cystatin C Level is a Predictor of Cardiac Events in Chronic Heart Failure Patients with Normal Creatinine Level(Clinical and Basic Research in Heart Failure (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PE-446 Carotid vascular remodeling is responsible for the aortic multiple vortex flow that contributes to the occurrence of acute cerebral embolism(Cerebrovascular Circulation/Stroke 2 (H) : PE76)(Poster Session (English))
• OE-183 Clinical Importance of Serum Heart-type Fatty Acid Binding Protein Levels in Heart Failure Patients : Comparisons with Sympathetic Nervous Activity(Heart Failure, Clinical 1 (M) : OE22)(Oral Presentation (English))
• OE-022 Prognostic Importance of ^I-MIBG Dynamic SPECT In Patients with Chronic Heart Failure(Nuclear Cardiology 1 (I) : OE3)(Oral Presentation (English))
• FRS-070 Isolated pulmonary arteriovenous shunt is a main embolic source in aged patients with cryptogenic stroke : A trans-esophageal contrast echocardiographic study(New Diagnostic Strategies (I) : FRS9)(Featured Research Session (English))
• Increased Serum Levels of H-FABP in Patients with Severe Congestive Heart Failure
• ^I-MIBG Dynamic SPECT in Patients with Congestive Heart Failure
• Direct evidence of apoptosis in patients with dilated cardiomyopathy : Elevated caspase activities in circulating blood
• ^I-BMIPP dynamic SPECT in patients with congestive heart failure
• Personality and Gastric Cancer Screening Attendance : A Cross-Sectional Analysis from the Miyagi Cohort Study
• Alcohol consumption and mortality in Japan : the Miyagi cohort study
• PJ-229 Optimal Pacing Site of Right Ventricular in Patients with Preserved Left Ventricular Function(PJ039,Cardiac Function (Clinical) 2 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Direct Evidence that Sustained Dysfunction of Left Atrial Appendage Contributes to the Occurrence of Cardiogenic Brain Embolism in Patients with Paroxysmal Atrial Fibrillation
• Aortic Atherosclerosis and Abnormalities of Blood Flow Conditions Are Important as Risk Factor for Ischemic Stroke in Non-Valvular Atrial Fibrillation
• Aortic Vortex Flow Represented by Contrast Echography Is a Useful Tool to Visualize Blood Viscosity in Acute Cerebral Embolism
• Ongoing myocardial damage relates to cardiac sympathetic nervous disintegrity in patients with heart failure
• Combination of conventional biomarkers for risk stratification in chronic heart failure
• PJ-779 8-Hydroxy-2'-Deoxyguanosine Predicts Adverse Clinical Outcomes in Patients with Heart Failure(PJ131,Heart Failure (Laboratory/Biomarkers) 2 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Risk Stratification of Chronic Heart Failure Patients by Multiple Biomarkers : Implications of BNP, H-FABP, and PTX3
• PJ-779 8-Hydroxy-2'-Deoxyguanosine Predicts Adverse Clinical Outcomes in Patients with Heart Failure(PJ131,Heart Failure (Laboratory/Biomarkers) 2 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Diminution of angiotensin II-induced contraction of the abdominal aorta isolated from Watanabe heritable hyperlipidemic rabbits
• A Role for Signal Transducer and Activator of Transcription 3, Mitogen-Activated Protein Kinases, and Akt for Cardiac Phenotypes in Vivo
• Pressure and Volume Overload-Induced Cardiac Hypertrophy Is Associated with Distinct Activation of Signal Transduction Pathways
• Artial Enlargement Induced by Volume Overload Is Associated with Altenations of Wnt Signaling Proteins
• Comparison of Nitric Oxide Production in Response to Carbachol Between Macrovascular and Microvascular Cardiac Endothelial Cells
• Protein kinase C-Calcineurin pathway is Involved in Insulin-Like Growth Factor-1-Induced Hypertrophy of Cultured Adult Rat Ventricular Myocytes
• Role of Calcineurin in Insulin-Like Growth Factor-1-Induced Hypertrophy of Cultured Adult Rat Ventricular Myocytes
• PE-493 Rapid Improvement of Impaired Endothelium-Dependent Vasodilation and Rac1/NADPH Oxidase-Derived ROS Generation in Vivo by Pravastatin(PE083,Cardiovascular Pharmacology (Basic), Cost-health Care System/DPC/Laws (H),Poster Session (English),The 73rd
• OE-091 Involvement of Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) in Advanced Glycation End Products (AGE)/RAGE-Signaling Pathways(OE16,Diabetes (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Risk of Breast Cancer in Japanese Women with Benign Breast Disease
• Risk Factors for Benign Breast Disease according to Histopathological Type : Comparisons with Risk Factors for Breast Cancer
• Trends in the Incidence of Female Breast and Cervical Cancers in Miyagi Prefecture, Japan, 1959-1987
• A Cohort Study on the Relation of Lifestyle, Personality and Biologic Markers to Cancer in Miyagi, Japan : Study Design, Response Rate and Profiles of the Cohort Subjects
• Dementia and Physical Disability as Competing Risks for Mortality in a Community-Based Sample of the Elderly Japanese
• Mast Cells Contribute to Flow Restoration by Bone Marrow Cell Transplantation in Rats With Ischemic Limbs
• RELATIONSHIP OF THALLIUM-201 DEFECT AND LEFT VENTRICULAR FUNCTION AFTER DIPYRIDAMOLE INFUSION
• Quantitative Assessment of Myocardial ^Tc-sestamibi Uptake During Exercise : Usefulness of Response Rate for Assessing Severity of Coronary Artery Disease
• OE-073 Quantitative Analysis of Change in Early Diastolic Strain Rate for Adenosine-Induced Myocardial Dysfunction(OE13,Echo/Doppler (New Technology) (I),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Impaired myocardial fatty acid metabolism detected by ^I-BMIPP in patients with unstable angina pectoris: Comparison with perfusion imaging by ^Tc-sestamibi
• PE-322 SPECT/CTCA Fusion Image is Useful for the Diagnosis of Coronary Artery Stenosis with Calcification(PE054,CT/MRI (New Technology) (I),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• DPJ-024 Serum NT-proBNP Level for Diagnosis of Diastolic Heart Failure in Japanese Population(DPJ04,Heart Failure (Diagnosis) (M),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• OE-027 Adaptive Servo Ventilation Improves Cardiac Function in Heart Failure Patients with Cheyne-Stokes Respiration(OE05,Obesity/SAS (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Dynamic ^I-MIBG SPECT reflects sympathetic nervous integrity and predicts clinical outcome in patients with chronic heart failure
• PE-429 Phosphorylation-independent regulation in cell distribution of signal transducer and activator of transcription (stat) in hypertrophied rabbit heart.(Cardiomyopathy, Basic and Clinical 1 (M) : PE73)(Poster Session (English))
• PE-321 A Pivotal Involvement of Toll-like Receptor-2 in the Pathogenesis of Cuff Induced Vascular Injury(Atherosclerosis, Basic 5 (IHD) : PE55)(Poster Session (English))
• PE-203 AT-1 Receptor Blockade Prevents Cardiac Hypertrophy through Inhibiting Protein Kinase C ε and Extracellular Signal-regulated Kinase in Renal Failure.(Kidney/Renal Circulation 1 (H) : PE35)(Poster Session (English))
• PE-005 Induction of atrial tachyarrythmia was associated with down-regulation of connexin family in dilated left atrium by volume overload(Arrhythmia, Basic 2 (A) : PE1)(Poster Session (English))
• OJ-532 Pitavastatin Inhibits Cardiac Hypertrophy in Rat Model of Progressive Renal Injury through Preventing the Activation of Extracellular-signal Regulated Kinase (ERK)(Kidney/Renal Circulation 3 (H) : OJ65)(Oral Presentation (Japanese))
• Dissimilar Contractile Responses of Right and Left Ventricles to Inotropic Interventions
• Protein Kinase C (PKC) and Extracellular-Signal Regulated Kinase (ERK) Are Involved in Cardiac Hypertrophy of Rat Chronic Renal Failure Model
• Increased Caspase Activity in Circulating Blood from Patients with Acute Myocardial Infarction
• -0841- DECREASE IN LEFT VENTRICULAR DISTENSIBILITY FOLLOWING STIFFENING OF THE RIGHT VENTRICULAR FREE WALL(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• Higher Efficacy of Urinary Bone Resorption Marker Measurements in Assessing Response to Treatment for Osteoporosis in Postmenopausal Women
• The Relationship of Thyroid Cancer with Radiation Exposure from Nuclear Weapon Testing in the Marshall Islands
• Associated factors of rehospitalization among schizophrenic patients
• Smoking, alcohol drinking, green tea consumption and the risk of esophageal cancer in Japanese men.
• A Prospective Cohort Study on National Health Insurance Beneficiaries in Ohsaki, Miyagi Prefecture, Japan : Study Design, Profiles of the Subjects and Medical Cost During the First Year
• Effects of Misclassification and Temporal Change of Response in Food Frequency on Risk Ratio
• Cost-Effectiveness Analysis of Mass Screening for Cervical Cancer in Japan
• Factors Related to the Desire to Enter a Nursing Home among Elderly Japanese
• Effects of Family-Togetherness on the Food Selection by Primary and Junior High School Students : Family-Togetherness Means Better Food
• Comparison of False Negative Rates among Breast Cancer Screening Modalities with or without Mammography: Miyagi Trial
• A new conceptualization for Mikulicz's disease as an IgG4-related plasmacytic disease
• -0718-FUNCTIONAL LEFT VENTRICULAR INTERACTION IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTION
• A case of systemic lupus erythematosus with postpartum hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome and concomitant high phosphatidylserine-dependent anti-prothrombin antibody levels
• Evaluation of the Effectiveness of Cervical Cancer Screening : A Case-Control Study in Miyagi, Japan
• Rheumatoid arthritis associated with ulcerative colitis
• Induction of nonspecific cross-reacting antigen mRNA by interferon-γ and anti-fibronectin receptor antibody in colon cancer cells
• Enhanced regional washout of technetium-99m-sestamibi in patients with coronary spastic angina
• Enhanced ^Tc-Sestamibi Washout in Patients with Coronary Spastic Angina
• Myocardial ^Tc-Sestamibi Washout in Patients with Dilated Cardiomyopathy : Comparisons with Endomyocardial Biopsy
• -1280-EFFECT OF HEART RATE ON THE LEFT VENTRICULAR END-SYSTOLIC PRESSUREVOLUME RELATIONSHIP : CHANGES IN REGIONAL PRELOAD : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -1260-THE EFFECT OF LEFT VENTRICULAR DIASTOLIC PRESSURE ON MYOCARDIAL FLOW DISTRIBUTION : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -450-PHASE ANALYSIS OF MYOCARDIAL SQUEEZING IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY : Coronary Circulation : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -407-EFFECT OF CALCIUM-BLOCKER (NIFEDIPINE) ON CORONARY VASODILATOR RESERVE IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY : Cardiomyopathy : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• OE-014 Toll-like Receptor-2 Modulates Cytokine Production After Myocardial Infarction(Vasoactive Compound/Growth Factor/Cytokine 1 (H) : OE2)(Oral Presentation (English))
• Fatty Acid Metabolic Imaging and Expression of Fatty Acid Utilization Enzymes in Eccentric Cardiac Hypertrohpy by Volume-Overload
• Differential Regulation of Akt Caused by Two Types of Hemodynamic Overload in Vivo
• Absence of Toll-Like Receptor-2 Modulates Ventricular Remodeling after Myocardial Infarction
• Efficacy and safety of rebamipide for the treatment of dry mouth symptoms in patients with Sjogren's syndrome : a double-blind placebo-controlled multicenter trial
• Presence of the 55 KDa glycosylation inhibiting factor in human serum
• Direct Evidence that Sustained Dysfunction of Left Atrial Appendage Contributes to the Occurrence of Cardiogenic Brain Embolism in Patients with Paroxysmal Atrial Fibrillation
• Iodine-123-metaiodobenzylguanidine imaging can predict future cardiac events in heart failure patients with preserved ejection fraction

もっと見る 閉じる

スポンサーリンク