Risk Stratification of Chronic Heart Failure Patients by Multiple Biomarkers : Implications of BNP, H-FABP, and PTX3
スポンサーリンク
概要
- 論文の詳細を見る
Background B-type natriuretic peptide (BNP), heart-type fatty acid-binding protein (H-FABP), and pentraxin 3 (PTX3) each predict adverse cardiac events in chronic heart failure (CHF) patients. For prognostic evaluation from different aspects, the utility of combined measurement of the 3 biomarkers in patients with CHF was examined in the present study. Methods and Results Levels of BNP (associated with left ventricular dysfunction, positive if >200pg/ml), H-FABP (marker of myocardial damage, positive if >4.1ng/ml), and PTX3 (marker of inflammation, positive if >4.0ng/ml) were measured in 164 consecutive CHF patients, and patients were prospectively followed with endpoints of cardiac death or rehospitalization. When patients were categorized on the basis of the number of elevated biomarkers, patients with 1,2, and 3 elevated biomarkers had a 5.4-fold (not significant), 11.2-old (p<0.05), and 34.6-fold increase (p<0.01), respectively, in the risk of adverse cardiac events compared with those without elevated biomarkers. Kaplan-Meier analysis revealed that patients with 3 elevated biomarkers had a significantly higher cardiac event rate than patients with a lower number of elevated biomarkers. Conclusion The combination of these 3 biomarkers could reliably risk-stratify CHF patients for prediction of cardiac events.
- 社団法人日本循環器学会の論文
- 2008-10-20
著者
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SUZUKI Satoshi
Department of Neurosurgery, Nippon Steel Yawata Memorial Hospital
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Takeishi Yasuchika
First department of internal medicine, Fukushima Medical University
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KUBOTA Isao
Department of Cardiology, Pulmonology and Nephrology, Yamagata University of School of Medicine
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Watanabe Tetsu
Department of Cardiology, Pulmonology, and Nephrology
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Miyashita Takehiko
Department of Cardiology, Pulmonology and Nephrology, Course of Internal Medicine and Therapeutics,
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Niizeki Takeshi
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
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Kubota Isao
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Kubota Isao
山形大学 医学部循環・呼吸・腎臓内科学
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Niizeki Takeshi
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Niizeki Takeshi
山形大学 医学部循環・呼吸・腎臓内科学
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Niizeki Takeshi
First Department Of Internal Medicine And Division Of Radiology Yamagata University School Of Medici
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Takeishi Y
First Department Of Internal Medicine Fukushima Medical University
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Takeishi Yasuchika
山形大学 医学部循環・呼吸・腎臓内科学
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Takeishi Yasuchika
First Department Of Internal Medicine Fukushima Medical University
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Tsunoda Yuichi
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Tsunoda Yuichi
山形大学 循環器内科
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Tsunoda Yuichi
山形大学 医学部第1内科
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Watanabe Tetsu
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Miyashita Takehiko
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Miyashita Takehiko
山形大学 医学部循環・呼吸・腎臓内科学
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Nitobe Joji
Department of Cardiorogy, Pulmonology, and Nephrology, Yamagata University School of Medicine
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Miyamoto Takuya
Department of Cardiology, Pulmonary and nephrology, Yamagata University School of Medicine
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Bilim Olga
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine
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Kitahara Tatsuro
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine
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Sasaki Toshiki
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
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Kitahara Tatsuro
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Miyamoto Takuya
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Miyamoto Takuya
山形大学 医学部循環・呼吸・腎臓内科学
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Nitobe Joji
山形大学 医学部循環・呼吸・腎臓内科学
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Nitobe Joji
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Nitobe Joji
First Department Of Internal Medicine Yamagata University School Of Medicine
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Takasaki Satoshi
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Sasaki Toshiki
Department Of Pathology Nakadori General Hospital
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Ishino Mitsunori
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University
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Bilim Olga
Department Of Cardiology Pulmonology And Nephrology Yamagata University Faculty Of Medicine
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Sasaki Toshiki
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Suzuki Satoshi
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Kubota Isao
The Fiest Department Of Internal Medicene Yamagata University School Of Medicine
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Takeishi Yasuchika
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Inoue Minoru
Department Of Cardiology Okitama Public General Hospital
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Ishino Mitsunori
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Tominaga Makoto
Department Of Laboratory Yamagata University School Of Medicine
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Tominaga Makoto
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Ishino Mitsunori
Department Of Cardiology Okitama Public General Hospital
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Takeishi Yasuchika
Division Of Cardiology Ishinomaki Red Cross Hospital
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Suzuki Satoshi
Department Of Anesthesiology And Resuscitology Okayama University Medical School
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Kubota Isao
Department Of Cardiology Pulmonology And Nephrology Yamagata University Of School Of Medicine
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Watanabe Tetsu
Department Of Basic Clinical Science And Public Health Tokai University School Of Medicine
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Suzuki Satoshi
Department Of Advanced Cardiac Therapeutics Fukushima Medical University
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Kitahara Tatsuro
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
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