Effects of a new cardiotonic agent 1,2-dihydro-6-methyl-2-oxo-5-(imidazo(1,2-a)pyridin-6-yl)-3-pyridine carbonitrile hydrochloride monohydrate (E-1020) on contractile force and cyclic AMP metabolism in canine ventricular muscle.
スポンサーリンク
概要
- 論文の詳細を見る
E-1020, a newly synthesized imidazopyridinylpyridine or imidazopyridine derivative (structurally closely related to the bipyridine derivative milrinone) increased the force of contraction and cyclic AMP levels in a concentration-dependent manner in the isolated canine ventricular trabeculae electrically driven at 0.5 Hz at 37°C. The concentration-response curve for the increase in force of contraction by E-1020 was biphasic. The maximal positive inotropic effect (PIE) of E-1020 is comparable to that of milrinone, and its potency is 3-fold less than that of milrinone, but 10-fold higher than that of amrinone. The time course of increases in force of contraction induced by E-1020 was coincident with that of cyclic AMP accumulation. The concentration-response curve for the PIE of E-1020 was superimposable to that of cyclic AMP accumulation. Aβ-adrenoceptor antagonist, (±)-bupranolol (3×10<SUP>-7</SUP> mol/l), did not affect the PIE of E-1020. The increase in the force of contraction and accumulation of cyclic AMP produced by E-1020 were inhibited by a muscarinic receptor agonist, carbachol. The relationship between the force of contraction and cyclic AMP levels in the presence of E-1020 was not modified by addition of carbachoi or isoproterenol. E-1020 shifted the concentration-response curve for isoproterenol to the left. E-1020 shortened the total duration of contraction and relaxation time of isometric contractions. These findings indicate that cyclic AMP is essentially involved in the PIE of E-1020 on the canine ventricular muscle, although the possible involvement of a cyclic AMPindependent mechanism can not be excluded.
- 公益社団法人 日本薬理学会の論文
著者
-
Satoh Hiroshi
Department Of Biology Faculty Of Science Shizuoka University
-
Endoh Masao
Department Of Cardiovascular Pharmacology Yamagata University School Of Medicine
-
ENDOH Masao
Department of Pharmacology, Yamagata University School of Medicine
-
SATOH Hiroshi
Department of Pharmacology, Yamagata University School of Medicine
関連論文
- Receptor Subtypes Mediating the Inotropic Effects and Ca2+ Signaling Induced by Endothelin-1 Through Crosstalk With Norepinephrine in Canine Ventricular Myocardium
- Factors Influencing Adherence in Outpatients Using Beclomethasone Dipropionate Inhaler for Bronchial Asthma
- Reproducibility of Nocturnal Blood Pressure Assessed by Self-Measurement of Blood Pressure at Home
- Epidemiology of Hypertension Based on Ambulatory Blood Pressure Monitoring and Self-Measurement of Blood Pressure at Home
- PE-222 The Decrease of Plaque Volume during PCI Has Negative Impact on Coronary Flow in Acute Myocardial Infarction(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 12 (IHD) : PE38)(Poster Session (English))
- Slow-Flow Phenomenon during Percutaneous Coronary Intervention in Acute Myocardial Infarction : An Intravascular Ultrasound Study
- The Influences of Hemodialysis and AV-Shunt on Bilateral Internal Thoracic Artery Flows : An Ultrasound Study
- Cardiac-specific Overexpression of Diacylglycerol Kinase ζ Prevents Angiotensin II-induced Cardiac Hypertrophy in Transgenic Mice(Cardiac Hypertrophy 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-062 Evaluation of Low- Non- Enhancement Myocardium on Cardiac Multi-Detector Row Computed Tomography (MDCT) in the Diagnosis of Myocardial Viability(PJ011,CT/MRI (Myocardium) 4 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Jap
- PE-309 Anemia in Chronic Kidney Disease (CKD) Deteriorates Left Ventricular Diastolic Function without Increasing Left Ventricular Mass Index (LVMI)(PE052,Kidney/Renal Circulation/CKD 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of Th
- OE-133 Thiol-Mediated Responses Contribute to the Biphasic Effects of Nitric Oxide (NO) on Mitochondrial Permeability Transition Pore(OE23,Heart Failure (Pathophysiology) (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese C
- FRS-065 Regulation of Mitochondrial Permeability Transition Pore by Glycogen Synthase Kinase 3β (GSK3β) is Related to Mitochondria-bound Hexokinase Activity(FRS13,Novel Molecular Mechanisms of Heart Failure 2 (M),Featured Research Session (English),The 73
- PJ-734 Global and Regional Analyses of 99mTc-sestamibi (MIBI) Imaging and Cardiac Magnetic Resonance Imaging (MRI) in Dilated Cardiomyopathy (DCM)(Nuclear cardiology(10)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circul
- PJ-627 Anemia Augments Left Ventricular Dysfunction in Patients with Chronic Kidney Disease(Cardiac function, basic/clinical(04)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-217 Different Effects of Palmitoyl-L-carnitine and Palmitoyl-CoA on Mitochondrial Function in Rat Myocytes(Metabolism/Biochemistry/Energetics(02)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-051 Dual Effects of Nitric Oxide on Mitochondrial Permeabillity Transition in Rat Ventricular Myocytes(Myocarditis, basic/clinical(M),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- P392 Effects of Mg^ on the Ca^ birnding capacity and Ca^ uptake activity of the sarcoplasmic reticulum
- EFFECTS OF SODIUM SELENITE ON DISTRIBUTION AND PLACENTAL TRANSFER OF MERCURIC MERCURY IN MICE OF LATE GESTATIONAL PERIOD
- PJ-337 The significance of Delayed Enhancement MRI to Evaluate Global and Local Left Ventricular Wall Function in Hypertrophic Cardiomyopathy(Cardiomyopathy, basic/clinical-5 (M) PJ57,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meetin
- OJ-002 Influence of Genetic Polymorphisms of OATP-C on Cholesterol Lowering Effect of Pravastatin(Cardiovascular pharmacology, basic/clinical-2 (H) OJ1,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation
- 4 Inhibition of Type-5 Phosphodiesterase : Promising Therapy for Pulmonary Hypertension(Which drug is useful for the treatment of pulmonary hypertension?,Topic 4 (TP4) (M),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Long-Term Survival in Patients with Pulmonary Hypertension Treated with a Type 5 Phosphodiesterase Inhibitor Sildenafil(Pulmonary Circulation 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OE-271 Pharmacokinetic and pharmacodynamic interactions between simvastatin and diltiazem in patients with hypercholesterolaemia and hypertension(Cardiovascular Pharmacology, Basic/Clinical 1 (H) : OE34)(Oral Presentation (English))
- Inhibition by Green Tea Extract of Diethylnitrosamine-initiated but Not Choline-deficient, L-Amino Acid-defined Diet-associated Development of Putative Preneo-plastic, Glutathione S-Transferase Placental Form-positive Lesions in Rat Liver
- Inhibition of Type 5 Phosphodiesterase : Promising Therapy for Pulmonary Hypertension
- A potential role of sildenafil in the management of pulmonary hypertension
- Nitric oxide : a negative feedback on endothelium-derived vascular relaxing factors
- Relationship between the β_3-Adrenoceptor Gene Variant and Body Fat in Japanese Children
- Protective Effect of Melatonin on Methylmercury-Induced Mortality in Mice
- ACUTE TOXICITY OF SODIUM SELENITE IN MICE OF LATE GESTATIONAL PERIOD
- PJ-541 The Species Dependence of Non-genomic Effects of Aldosterone : Analysis of [Na^+] _i and pH_i in Rat and Guinea Pig Ventricular Myocytes(Neurohumoral factors-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Determinants of Circadian Blood Pressure Variation : A Community-Based Study in Ohasama
- Predictive Value of Home Blood Pressure Measurement in Relation to Stroke Morbidity: A Population-Based Pilot Study in Ohasama, Japan
- Effects of Hair Treatment on Hair Mercury-The Best Biomarker of Methylmercury Exposure?
- Prevalence of prostatitis-like symptoms in Japanese men : Population-based study in a town in Hokkaido
- An S-Nitrosylated Hemoglobin Derivative Protects the Rat Hippocampus From Ischemia-Induced Long-Term Potentiation Impairment With a Time Window
- Effects of Family-Togetherness on the Food Selection by Primary and Junior High School Students : Family-Togetherness Means Better Food
- Peak Systolic Blood Pressure in Exercise Testing is Associated With Scintigraphic Severity of Myocardial Ischemia in Patients With Exercise-Induced ST-Segment Depression
- Relationship of dysregulation of glucose metabolism with white-coat hypertension : the Ohasama study
- A Simple Risk Score for Predicting In-hospital Mortality in Patients with Acute Myocardial Infarction who Underwent Emergency Coronary Angiography
- Drug Compliance in Patients with Bronchial Asthma : Relation among Compliance with Different Types of Antiasthmatic Drug and Association with Daily Administration Frequency
- Analysis of Drug Compliance in Adult Patients with Bronchial Asthma
- The Brain Histamine (HA) and Putuitary Luteinizing Hormone (LH) Levels in Female Rats Anesthetized with Ether on Proestrus
- Cardiac Ca^ Signaling and Ca^ Sensitizers
- The Tohoku Study of Child Development : A Cohort Study of Effects of Perinatal Exposures to Methylmercury and Environmentally Persistent Organic Pollutants on Neurobehavioral Development in Japanese Children
- A Novel Noninvasive Method to Evaluate Baroreceptor Sensitivity (BRS) Using Impulse Response Function (IRF) with Autoregression Model
- I-123 MIBG Scintigraphy for the Evaluation of Cardiac Sympathetic Nerve Activity (SNA) : Comparison with Impulse Response Function (IRF)
- Sildenafil, a Type-5 Phosphodiesterase Inhibitor, Improves Vascular Response to Reactive Hyperemia in Patients with Raynaud's Phenomenon
- OJ-048 Usefulness of Delayed Enhancement Magnetic Resonance Imaging to Differentiate Dilated phase of Hypertrophic Cardiomyopathy from Dilated Cardiomyopathy(Cardiomyopathy, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation
- PE-612 Non-genomic Effects of Aldosterone on Intracellular Ion Regulation and Cell Function in Rat Ventricular Myocytes(Neurohumoral factors-2 (H) PE108,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation So
- PE-597 Protein Kinase A (PKA)-induced Alterations in Mitochondrial Function is Regulated by Reactive Oxygen Species in Rat Cardiomyocytes(Metabolism/Biochemistry/Energetics-2 (M) PE105,Poster Session (English),The 70th Anniversary Annual Scientific Meetin
- PE-187 The Interaction of NO and 20-HETE in the Reduction of Cerebral Blood Flow Following Subarachnoid Hemorrhage in Rats(Cerebrovascular circulation/Stroke-2 (IHD) PE32,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japan
- PE-073 Novel Property of Amlodipine to Improve Disturbed Endothelial Barrier Function by Mechanisms Other than the Effect on Voltage-dependent Calcium Channel(Cardiovascular pharmacology, basic/clinical-3 (H) PE13,Poster Session (English),The 70th Anniver
- PE-028 The Extensive Epicardial Delayed Potential Relates to Induction of Ventricular Fibrillation in Asymptomatic Patients with Brugada Syndrome(Arrhythmia, diagnosis/pathophysiology/EPS-7 (A) PE5,Poster Session (English),The 70th Anniversary Annual Scie
- Factors Affecting Hand Tremor and Postural Sway in Children
- HISTOGENETIC STUDIES ON ALLERGIC DERMATITIS OF HORSES I. : SYNTHETIC EXAMINATION OF BIOPSY FINDINGS
- PATHOLOGICAL STUDIES ON SO-CALLED "KIRIYOI DISEASE"
- GASTRIC EROSION IN HORSES AFFECTED WITH JAPANESE ENCEPHALITIS
- Is SPECT Cost-Effective in Managing Ischemic Heart Disease (IHD) in Japan? Comparison with Exercise ECG-Testing (EET) and Coronary Angiography (CAG)
- 3 Stress Myocardial SPECT Is Cost-effective in Diagnosis And Management of Ischemic Heart Disease (IHD) in Diagnosis Procedure Combination (DPC) Era(Plenary Session 6 (PL6) (I) : Role of Diagnostic Imaging in the Management of Coronary Artery Disease and
- Distribution of Selenium in Human Plasma Detected by High Performance Liquid Chromatography-Plasma Ion Source Mass Spectrometry
- Growth Reacceleration of School Children in the City of Sendai, Japan
- The Usefulness of Delayed Enhancement Magnetic Resonance Imaging for Diagnosis of Cardiac Sarcoidosis (Cardiomyopathy, Clinical 5 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Differential Diagnosis of Dilated Phase of Hypertrophic Cardiomyopathy by Using Delayed Enhancement Magnetic Resonance Imaging (DE-MRI)(Cardiomyopathy, Clinical 7 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Characterization of Spotted Fever Group Rickettsiae Detected in Dogs and Ticks in Okinawa, Japan
- First Detection of Ehrlichia platys in Dogs and Ticks in Okinawa, Japan
- Seroprevalence of Antibodies against Spotted Fever Group Rickettsia among Dogs and Humans in Okinawa, Japan
- Non-genomic Effects of Aldosterone on Intracellular Na^+ Concentration in Rat Ventricular Myocytes : Analysis Using Sodium-green With Laser Scanning Confocal Microscopy(Neurohumoral Factors 3 (H), The 69th Annual Scientific Meeting of the Japanese Circula
- Direct Effects of Protein Kinase A on Mitochondrial Membrane Potential and Redox State are Mediated by Reactive Oxygen Species(ROS)(Metabolism/Biochemistry/Energetics 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-037 Myocardial perfusion imaging SPECT (MPI) and pressure wire-derived fractional flow reserve (FFRmyo) are discordant in coronary ischemia(Nuclear Cardiology 5 (I) : PE7)(Poster Session (English))
- Microwave Digestion Using Dual PTFE Containers for Analysis of Trace Elements in Small Amounts of Biological Samples
- Analysis of Trace Elements in the Central Nerve Tissues with Inductively Coupled Plasma-Mass Spectrometry
- Spatial difference of Ca^ transients in ventricular myocyts of adult and new born rabbits
- The Roles of Mitochondrial Permeability Transition Pore in Regulation of Mitochondrial Ca^ Concentration in Skinned Rat Myocytes
- Confocal Imaging of the Opening of Mitochondrial Permeability Transition Pore in Cardiac Myocytes
- A Preliminary Note on the Karyotypes of Giant Flying Squirrels Petaurista alborufus and P. petaurista
- CORTICAL CEREBELLAR ATROPHY OF GRANULAR TYPE IN JAPANESE CATTLE
- Developmental Neurotoxicity Following Prenatal Exposures to Methylmercury and PCBs in Humans from Epidemiological Studies
- Dietary Habits and Selenium Intake of Residents in Mountain and Coastal Communities in Japan
- Role of basic fibroblast growth factor in the healing of gastric ulcer in rats
- METALLOTHIONEIN (MT-1, -2) DEFICIENCY INDUCED DOWN-REGULATION OF DOPAMINERGIC NEURON IN METALLOTHIONEIN-KNOCKOUT AND/OR Hg^0-EXPOSURED MICE BRAIN
- Acute Mercury Poisoning by Intentional Ingestion of Mercuric Chloride
- ELECTRON MICROSCOPIC OBSERVATIONS OF THE EQUINE PARATHYROID GLANDS WITH PARTICULAR REFERENCE TO THOSE OF EQUINE OSTEODYSTROPHIA FIBROSA
- THE PATHOLOGICAL STUDY OF PARATUBERCULOSIS IN GOATS, CENTERED AROUND THE FORMATION OF REMOTE LESIONS
- Novel method of confocal imaging of mitochondrial Ca in saponin-permeabilized cardiac myocytes
- EFFECTS OF SELENITE ON BIOTRANSFORMATION OF METHYLMERCURY IN PREGNAMT MICE (The 6th Meeting for the Study of Toxic Effect)
- DISCOVERY OF A CASE OF TRICHINOSIS IN JAPAN
- Distribution of Melanocytes in Feather Germs of a Plumage Mutant Bh (Black at Hatch) Embryo of Japanese Quail (Coturnix coturnix japonica)
- Bh (black at hatch) gene appears to be expressed in melanocytes of feather germs in the Japanese quail (Coturnix coturnix japonica)
- Bh (black at hatch) Gene Appears to Cause Hemorrhage in the Homozygous Quail Embryo Lung
- AN OBSERVATION ON BOVINE MALIGNANT CATARRH IN JAPAN
- Effects of corticotropin-releasing factor relating peptide, urocortin, on cell contraction and Ca^ in isolated rat ventricular myocytes
- Comparison of Gastrointestinal Adverse Effects of Ketoprofen between Adult and Young Cats
- Fries rearrangement in calixarene esters. A new entry for the synthesis of p-substituted calixarenes.
- Changes of Blood Biochemical Values in Ponies Recovering from Hyperlipemia in Japan
- Effects of a new cardiotonic agent 1,2-dihydro-6-methyl-2-oxo-5-(imidazo(1,2-a)pyridin-6-yl)-3-pyridine carbonitrile hydrochloride monohydrate (E-1020) on contractile force and cyclic AMP metabolism in canine ventricular muscle.
- Effects of cardioplegia induced by a young's solution (YNG solution) on the blood-perfused canine papillary muscle preparation.
- The sequence and correlation of the changes in several parameters of energy metabolism induced by ischemic insult in heart muscle.
- Drinking Habits Influence the Relationship between Apolipoprotein AII and Body Mass Index.
- Aldosterone-to-renin ratio and home blood pressure in subjects with higher and lower sodium intake : the Ohasama Study