Effects of cardioplegia induced by a young's solution (YNG solution) on the blood-perfused canine papillary muscle preparation.
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概要
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Experiments were carried out in the blood-perfused canine papillary muscle preparation to evaluate the protective effect of a cardioplegic solution, Young's solution (YNG solution), on the myocardial function. Both in spontaneously contracting preparations and in electrically paced (2Hz) preparations, the time to the cardiac arrest and the time to the maximum blood flow were found to be significantly shorter when the cardiac arrest was induced with cardioplegic solutions than when it was induced with the cold modified Krebs-Ringer's solution (cold cardioplegia). The maximum blood flow of the paced preparation tended to be greater with cardioplegic solutions. The time to resumption of regular contractions was significantly shorter with YNG solution as compared with cold cardioplegia. The developed tension and the blood flow at the time of resumption of the regular contractions tended to approach the control value more quickly with YNG solution, as compared with other cardioplegic solutions and cold cardioplegia. It is concluded that YNG solution represents an optimal cardioplegic solution.
- International Heart Journal刊行会の論文
著者
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Imai Shoichi
Department Of Phamacology Niigata University School Of Medicine
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Katano Yumi
Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine
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Kawada Tomie
Research Institute Of Pharmaceutical Sciences Musashino University
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Satoh Hiroshi
Department Of Biology Faculty Of Science Shizuoka University
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Suzuki Kenichi
Department Of Biochemistry Meiji College Of Pharmacy:central Research Institute Yamanouchi Parmaceut
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OTORII Takeshi
Department of Pharmacology, Yamagata University School of Medicine
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OTORII Takeshi
Department of Phamacology, Niigata University School of Medicine
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YOSHIDA Seiichiro
Department of Pharmacology, Yamagata University School of Medicine
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OHKUBO Kazuhiro
Department of Pharmacology, Yamagata University School of Medicine
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