Diverse Relaxation Responses of Canine Large and Small Conductive Coronary Arteries to Glyceryl Trinitrate and Nitric Oxide on the One Hand and to 8-Bromoguanosine 3':5' Cyclic Monophosphate on the Other
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概要
- 論文の詳細を見る
Glyceryl trinitrate (GTN) and nitric oxide (NO) preferentially relaxed the large (2 mm in diameter) conductive coronary artery (CCA) of the dog, while 8-bromoguanosine 3′:5′ cyclic monophosphate preferentially relaxed the small one (0.6 mm in diameter). Nither L-cysteine nor L-acetylcysteine affected GTN-induced relaxation in small- and large-CCA. These results indicate that not different biotransformation of GTN to NO, but a process or processes operative between activation of guanylate cyclase and that of cyclic GMP-dependent protein kinase seems to be responsible for the preferential dilatation of large-CCA.
- 社団法人 日本薬理学会の論文
著者
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Ishibashi Takaharu
新潟大学 薬理
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Ishibashi Takaharu
Department Of Pharmacology Asahikawa Medical College
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Imai Shoichi
Department Of Phamacology Niigata University School Of Medicine
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Imai S
Department Of Pharmacology Niigata University School Of Medicine
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Kitagawa Toshikazu
Department Of Energy And Hydrocarbon Chemistry Graduate School Of Engineering Kyoto University
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Kitagawa Toshikazu
Department Of Pharmacology Niigata University School Of Medicine
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Kitagawa Toshikazu
Department of Chemistry for Materials, Graduate School of Engineering, Mie University, Tsu 514-8507, Japan
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ISHIBASHI Takaharu
Department of Pharmacology, Niigata University School of Medicine
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ISHIBASHI Takaharu
Department of Pharmacology and, Niigata University School of Medicine
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