Quantitative Analysis of the Antiarrhythmic Effect of Drugs on Canine Ventricular Arrhythmias by the Determination of Minimum Effective Plasma Concentrations : Pharmacology and Clinical Evaluation of Antiarrhythmic Drugs
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概要
- 論文の詳細を見る
Antiarrhythmic effects and minimum antiarrhythimic plasma concentrations (min PC) were examined using three canine ventricular arrhythmia models, i.e., two-stage coronary ligation arrhythmia (Cor), halothane-adrenaline arrhythmia (Adr) and digitalis arrhythmia (Dig). Disopyramide suppressed these three arrhythmias and its min PCs were 5.3 ± 1.8 (Cor), 4.2 ± 1.1 (Adr) and 1.7 ± 0.4 μg/ml (Dig). Procainamide suppressed coronary ligation arrhythmia and its min PC was 27.1 ± 4.0 μg/ml, but was not effective on adrenaline arrhythmia. Aprindine was effective on three arrhythmias and its min PCs were 1.6 ± 0.3 (Cor), 1.0 ± 0.4 (Adr) and 0.8 ± 0.4μg/ml (Dig). Lidocaine was not effective on coronary ligation arrhythmia, but was effective on adrenaline arrhythmia and its min PC was 15 μg/ml. Phenytoin was effective on three arrhythmias and its min PCs were 9.8 ± 2.0 (Cor), 12.1 ± 3.1 (Adr) and 11.3 ± 3.0 μg/ml (Dig). It was not specifically effective on canine digitalis arrhythmia. Propranolol and other β-blockers were effective on adrenaline arrhythmia, but very high doses were necessary for suppressing coronary ligation and digitalis arrhythmias. Verapamil was only effective on adrenaline arrhythmia and its min PC was 0.03 ± 0.01 μg/ml. Canine min PCs of drugs were almost the same as those reported in man except for procainamide and lidocaine. Membrane stabilizing effects seem to be important for suppressing canine ventricular arrhythmias.
- 社団法人日本循環器学会の論文
- 1983-01-20
著者
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HASHIMOTO Keitaro
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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IMAI Shoichi
Department of Pharmacology, Niigata University School of Medicine
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Imai Shoichi
Department Of Phamacology Niigata University School Of Medicine
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Satoh Hiroyasu
Department Of Pharmacology Division Of Molecular And Cellular Biology Nara Medical University
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SHIBUYA TOSHIYUKI
Department of Phamacology, Niigata University School of Medicine
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Satoh Hiroyasu
Department Of Pharmacology Yamanashi Medical College
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Shibuya Toshiyuki
Department Of Phamacology Niigata University School Of Medicine
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Keitaro
Department Of Pharmacology Niigata University School Of Medicine
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Satoh Hiroyasu
Department Of Chemistry School Of Science Kitasato University
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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