Cardiac Effects of a Selective Rho-Associated Kinase Inhibitor, Y-27632, Assessed in Canine Isolated, Blood-Perfused Heart Preparations
スポンサーリンク
概要
- 論文の詳細を見る
Chronotropic, inotropic and coronary effects of Y-27632 ((+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl) cyclohexanecarboxamide dihydrochloride, monohydrate), a specific inhibitor of Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK), were assessed using canine isolated, blood-perfused heart preparations. Y-27632 slightly enhanced sinoatrial automaticity and significantly increased coronary blood flow, while it decreased ventricular contraction. The concentrations of Y-27632 needed to cause the currently observed changes were similar to those inhibiting ROCK in a previous in vitro study. These results suggest that the constitutional ROCK in the heart mainly regulates the ventricular contractility and coronary vascular tone rather than the sinoatrial automaticity.
- 社団法人 日本薬理学会の論文
- 2002-03-01
著者
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矢冨 裕
Department Of Clinical Laboratory The University Of Tokyo Hospital
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Yatomi Yutaka
山梨大学 医学部臨床検査医学
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Yatomi Yutaka
Department Of Pharmacology University Of Yamanashi Faculty Of Medicine
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Yatomi Yutaka
山梨大学 薬理
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矢冨 裕
山梨医科大学臨床検査医学
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矢冨 裕
山梨医科大学 医学部 臨床検査医学講座
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HASHIMOTO Keitaro
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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Sugiyama Atsushi
Department of Pharmacology, School of Medicine, Toho University, Japan
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Satoh Y
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Yatomi Yutaka
Department Of Clinical Laboratory Medicine Graduate School Of Medicine The University Of Tokyo
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Takahara Akira
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Satoh Yoshioki
Department of Pharmacology, Yamanashi Medical University
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Satoh Yoshioki
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Yatomi Yutaka
Department Of Laboratory Medicine Graduate School Of Medicine University Of Tokyo
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Takahara Akira
Department Of Internal Medicine National Kawatana Hospital
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical University
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Sugiyama A
Department Of Pharmacology Yamanashi Medical University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Sugiyama Atsushi
Department Of Pharmacology. University Of Yamanashi Yamanashi Research Center Of Cliniacl Pharmacolo
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Sugiyama Atsushi
Department Of Chemistry College Of Science Rikkyo University
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Aikawa Tokiko
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Sugiyama Atsushi
Department Of Pharmacology School Of Medicine Toho University
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Yatomi Yutaka
Department Of Clinical Laboratory Graduate School Of Medicine The University Of Tokyo
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HASHIMOTO Keitaro
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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Yatomi Yutaka
Department Clinical Laboratory Medicine, Graduate School of Medicine and Faculty of Medicine, University of Tokyo
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Sugiyama Atsushi
Department of Biotechnology, Faculty of Engineering, Kansai University
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YATOMI Yutaka
Department of Clinical and Laboratory Medicine, Yamanashi Medical College
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Takahara Akira
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Toho University
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