In Vivo Electropharmacological Effects of Amiodarone and Candesartan on Atria of Chronic Atrioventricular Block Dogs
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概要
- 論文の詳細を見る
Electropharmacological effects of chronically administered amiodarone and candesartan on atria that had been remodeled against congestive heart failure were assessed using dogs (about 10 kg in weight) with chronic atrioventricular block. Amiodarone was administered orally in a dose of 200 mg/body per day for the initial 7 days followed by 100 mg for the following 21 days (n = 7). Candesartan was administered in a dose of 12 mg/body per day for 28 days (n = 7). All animals survived the 4-week experimental period, indicating the lack of risks for inducing cardiohemodynamic collapse or torsade de pointes by these drugs. The plasma amiodarone concentration was 353 ng/ml at 4 weeks of treatment. Before candesartan treatment (control), intravenous administration of 30 ng/kg of angiotensin II increased the mean blood pressure by 18 mmHg, which was significantly decreased to 1 mmHg by 4 weeks of treatment. Amiodarone prolonged the atrial effective refractory period without affecting inter-atrial conduction time and decreased the duration of the burst pacing-induced atrial fibrillation, whereas candesartan hardly affected these variables. These results indicate that amiodarone should become a pragmatic pharmacological strategy against atrial fibrillation in patients with chronically compensated heart failure and suggest that a much higher dose of candesartan may be needed to exert its efficacy in this model.
- 社団法人 日本薬理学会の論文
- 2007-02-20
著者
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Aonuma Kazutaka
Division of Cardiovascular Medicine. Tsukuba University
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MATSUMOTO Masahiko
Department of Biochemistry, School of Medicine, Tokai University
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Sugiyama Atsushi
Department of Pharmacology, School of Medicine, Toho University, Japan
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Nakamura Yuji
Department of Pharmacology, School of Medicine, Toho University, Japan
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Nakamura Yuji
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Takahara Akira
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Aonuma Kazutaka
Division Of Cardiology Graduate School Of Comprehensive Human Science University Of Tsukuba
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WANG Kai
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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Wang Kai
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Wang Kai
Department Of Electric And Electronic Engineering Graduate School Of Engineering Miyazaki University
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Matsumoto Masahiko
Department Of Biochemistry School Of Medicine Tokai University
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Takahara Akira
Department Of Internal Medicine National Kawatana Hospital
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical University
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Sugiyama A
Department Of Pharmacology Yamanashi Medical University
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Matsumoto Masahiko
Department Of Surgery Interdisciplinary Graduate School Of Medicine And Engineering University Of Ya
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Nakamura Yuji
Department Of Materials Engineering Graduate School Of Engineering The University Of Tokyo:crest Jap
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Wang Kai
Department Of Biostatistics University Of Iowa
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Nakamura Yuji
Department Of Anesthesiology Shimane Medical University
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical College
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Sugiyama Atsushi
Department Of Pharmacology. University Of Yamanashi Yamanashi Research Center Of Cliniacl Pharmacolo
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Sugiyama Atsushi
Department Of Chemistry College Of Science Rikkyo University
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Nakamura Yuji
Department Of Agricultural Chemistry Faculty Of Agriculture Kyushu University
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Aikawa Tokiko
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Sugiyama Atsushi
Department Of Pharmacology School Of Medicine Toho University
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Sugiyama Atsushi
Department of Biotechnology, Faculty of Engineering, Kansai University
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Takahara Akira
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Toho University
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