Comparison of Electropharmacological Effects of Bepridil and Sotalol in Halothane-Anesthetized Dogs
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概要
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Background Bepridil is known to have a multiple ion channel-blocking property in the heart, which has been applied for the treatment of atrial fibrillation and drug-refractory ventricular tachyarrhythmias. In this study, the electro-pharmacological effects of bepridil were compared with those of dl-sotalol, a representative class III anti-arrhythmic drug, using the halothane-anesthetized canine model. Methods and Results Cardiovascular and electrophysiological variables were measured under the halothane anesthesia. Intravenous administration of bepridil (0.3 mg/kg, n=4) delayed the intraventricular conduction and prolonged the ventricular effective refractory period, whereas dl-sotalol (0.3 mg/kg, iv, n=4) inhibited atrioventricular conduction and prolonged the atrial and ventricular effective refractory period. The additional administration of 10 times the higher dose of bepridil or dl-sotalol (ie, 3 mg/kg, iv, n=4 for each group) decreased blood pressure, suppressed ventricular contraction and sinus automaticity, and prolonged the atrial and ventricular effective refractory period and monophasic action potential duration, in addition to the effects of the low dose. Conclusions The electropharmacological effects of bepridil and dl-sotalol were similar, although their potency for each cardiovascular variable varied significantly. These findings can be useful when selecting these drugs according to the pathophysiological condition of a patient.
- 社団法人日本循環器学会の論文
- 2008-05-20
著者
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Iwasaki Hiroshi
Department of Pathology, Faculty of Medicine, Fukuoka University
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Iwasaki Hiroshi
Department Of Anesthesiology And Critical Care Medicine Asahikawa Medical College
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Sugiyama Atsushi
Department of Pharmacology, School of Medicine, Toho University, Japan
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Nakamura Yuji
Department of Pharmacology, School of Medicine, Toho University, Japan
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Nakamura Yuji
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Takahara Akira
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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MITSUMORI Yoshitaka
Department of Cardiovascular Surgery, Yamanashi Central Hospital
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Mitsumori Yoshitaka
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Mitsumori Yoshitaka
Department Of Cardiovascular Surgery Yamanashi Central Hospital
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Iwasaki Hiroshi
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Takahara Akira
Department Of Internal Medicine National Kawatana Hospital
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Ishizaka Tomomichi
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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Kise Hiroaki
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical University
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Sugiyama A
Department Of Pharmacology Yamanashi Medical University
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Nakamura Yuji
Department Of Materials Engineering Graduate School Of Engineering The University Of Tokyo:crest Jap
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Kise Hiroaki
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Ishizaka Tomomichi
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical College
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Sugiyama Atsushi
Department Of Pharmacology. University Of Yamanashi Yamanashi Research Center Of Cliniacl Pharmacolo
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Sugiyama Atsushi
Department Of Chemistry College Of Science Rikkyo University
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Nakamura Yuji
Department Of Agricultural Chemistry Faculty Of Agriculture Kyushu University
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Aikawa Tokiko
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Sugiyama Atsushi
Department Of Pharmacology School Of Medicine Toho University
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Sugiyama Atsushi
Department of Biotechnology, Faculty of Engineering, Kansai University
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Takahara Akira
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Toho University
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