In Vivo Antiarrhythmic Profile of AP-792 Assessed in Different Canine Arrhythmia Models
スポンサーリンク
概要
- 論文の詳細を見る
The antiarrhythmic effects of a novel antiarrhythmic drug AP-792, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-cyclohexylbutyl]piperidine hydrochloride, were analyzed using the epinephrine-, digitalis-and two-stage coronary ligation-induced canine ventricular arrhythmia models. Intravenous administration of AP-792 (0.3 or 1.0 mg/kg) effectively suppressed each of the ventricular arrhythmias, an action that resembles that of a typical cardioselective Ca2+ channel blocker, AH-1058. The antiarrhythmic action of AP-792 was slow in onset and longer-lasting than those in our previous studies using more than 50 antiarrhythmic drugs, including Na+ and Ca2+ channel blockers. These results suggest that AP-792 can become a unique long-acting antiarrhythmic drug.
- 社団法人 日本薬理学会の論文
- 2001-09-01
著者
-
HASHIMOTO Keitaro
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
-
Sugiyama Atsushi
Department of Pharmacology, School of Medicine, Toho University, Japan
-
Hirasawa Akira
Pharmaceutical Research Laboratories Ajinomoto Co. Inc.
-
TAKAHARA Akira
Pharmaceutical Research Laboratories, Ajinomoto Co., Inc.
-
DOHMOTO Hideki
Pharmaceutical Research Laboratories, Ajinomoto Co., Inc.
-
SHOJI Masataka
Pharmaceutical Research Laboratories, Ajinomoto Co., Inc.
-
YOSHIMOTO Ryota
Pharmaceutical Research Laboratories, Ajinomoto Co., Inc.
-
Dohmoto Hideki
Pharmaceutical Research Laboratories Pharmaceuticals Company Ajinomoto Co. Inc.
-
Takahara Akira
Pharmaceutical Research Laboratories Ajinomoto Co. Inc.
-
Shoji Masataka
Pharmaceutical Research Laboratories Ajinomoto Co. Inc.
-
Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical University
-
Yoshimoto Ryota
Pharmaceutical Research Laboratories Pharmaceuticals Company Ajinomoto Co. Inc.
-
Yoshimoto Ryota
Pharmaceutical Research Laboratories Ajinomoto Co. Inc.
-
Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
-
Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
-
Sugiyama Atsushi
Department Of Pharmacology. University Of Yamanashi Yamanashi Research Center Of Cliniacl Pharmacolo
-
Sugiyama Atsushi
Department Of Chemistry College Of Science Rikkyo University
-
Aikawa Tokiko
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
-
Sugiyama Atsushi
Department Of Pharmacology School Of Medicine Toho University
-
HASHIMOTO Keitaro
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
-
HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
-
Sugiyama Atsushi
Department of Biotechnology, Faculty of Engineering, Kansai University
関連論文
- PRACTICAL APPLICATION OF GUINEA PIG TELEMETRY SYSTEM FOR QT EVALUATION
- Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research:In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome: Development of Chronic Atrioventricular Block Model of Microminipig
- Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research:Preface
- In Vivo Electropharmacological Effects of Amiodarone and Candesartan on Atria of Chronic Atrioventricular Block Dogs
- Comparison of Four Rate-Correction Algorisms for the Ventricular Repolarization Period in Assessing Net Effects of I_ Blockers in Dogs
- OJ-071 Chronic Atrioventricular Block Abbreviated the Action Potential Duration of Canine Pulmonary Vein Myocardium(Arrythmia, basic(02)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Analysis of Arrhythmogenic Profile in a Canine Model of Chronic Atrioventricular Block by Comparing In Vitro Effects of the Class III Antiarrhythmic Drug Nifekalant on the Ventricular Action Potential Indices Between Normal Heart and Atrioventricular Bloc
- Effect of the New Class III Antiarrhythmic Drug MS-551 and d-Sotalol on Canine Coronary Ligation-Reperfusion Ventricular Arrhythmias
- In Vivo Antiarrhythmic Profile of AP-792 Assessed in Different Canine Arrhythmia Models
- Comparison of the Electropharmacological Effects of Verapamil and Propranolol in the Halothane-Anesthetized In Vivo Canine Model Under Monophasic Action Potential Monitoring
- Pravastatin Prevents Arrhythmias Induced by Coronary Artery Ischemia/Reperfusion in Anesthetized Normocholesterolemic Rats
- P6-14 Development of telemetry system for QT evaluation in guinea pigs(LIVER AND DIGESTIVE SYSTEM/CIRCULATORY SYSTEM-1/DEVELOPMENT AND REPRODUCTION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Effects of Intravenous Anesthetics on Function and Metabolism in the Reperfused Working Rat Heart
- Constitutional Rho-Kinase Regulates the Electrophysiological and Mechanical Function of the Heart Besides the Coronary Vascular Tone
- Cardiac Effects of a Selective Rho-Associated Kinase Inhibitor, Y-27632, Assessed in Canine Isolated, Blood-Perfused Heart Preparations
- Effects of Sphingosine 1-Phosphate, a Naturally Occurring Biologically Active Lysophospholipid, on the Rat Cardiovascular System
- Antiarrhythmic and Proarrhythmic Effects of Sematilide in Canine Ventricular Arrhythmia Models
- Effects of KB-R9032, a new Na^+/H^+ Exchange Inhibitor, on Canine Coronary Occlusion/Reperfusion-Induced Ventricular Arrhythmias
- Block of Na exchangers on ischemia induced arrhythmias
- Effects of Acute Intravenous Administration of Pentamidine, a Typical hERG-Trafficking Inhibitor, on the Cardiac Repolarization Process of Halothane-Anesthetized Dogs
- DEVELOPMENT OF TELEMETRY SYSTEM IN THE COMMON MARMOSET : CARDIOVASCULAR EFFECTS OF ASTEMIZOLE AND NICARDIPINE
- 0453 INHIBITION OF Na^+/H^+ EXCHANGE SUPPRESSES BOTH REBOUND RECOVERY OF MYOCARDIAL CREATINE PHOSPHATE (Cr-P) AND LETHAL ARRHYTHMIAS DURING REPERFUSION AFTER A BRIEF ISCHEMIA
- Inhibitory Effects of a Newly Synthesized 5-HT_2 Receptor Antagonist, AT-1015 (N-[2-[4-(5H-Dibenzo[a, d]cyclohepten-5-ylidene)piperidino]-ethyl]-1-formyl-4-piperidinecarboxamide Monohydrochloride Monohydrate), on Contraction and Relaxation of Pig Coronary
- Simultaneous Assessment of Pharmacokinetics of Pilsicainide Transdermal Patch and Its Electropharmacological Effects on Atria of Chronic Atrioventricular Block Dogs
- Comparison of Electropharmacological Effects of Bepridil and Sotalol in Halothane-Anesthetized Dogs
- OJ-006 Comparison of Electropharmacological Effects of Sotalol and Bepridil Assessed in the in Vivo Canine Heart(Cardiovascular pharmacology, basic/clinical-2 (H) OJ1,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japan
- Purification and Properties of an Aminopeptidase from a Protamine-degrading Marine Bacterium
- Microbial Transformation of Carbazole to Indole-3-acetic Acid by Flavobacterium sp. OCM-1
- Clinical utility of quantitative RT-PCR targeted to α1,4-N-acetylglucosaminyltransferase mRNA for detection of pancreatic cancer
- Suppressive effect of rice extract on Helicobacter pylori infection in a Mongolian gerbil model
- Eradication of Helicobacter pylori decreases mucosal alterations linked to gastric carcinogenesis in Mongolian gerbils
- Dissolution Process of Copper Sulfate into Water in a Heterogeneous Vertical Magnetic Field
- P400 CAN THE MAP TECHNIQUE BE APPLIED TO DETECT DELAYED AFTERDEPOLARIZATION ? : ELECTROPHYSIOLOGICAL AND PHARMACOLOGICAL EVIDENCE
- 0901 EFFECT OF A CLASS III ANTIARRHYTHMIC DRUG ON REFRATORY PERIOD. : DEMONSTRATION OF REVERSE USE DEPENDENCY ASSESSED BY MONOPHASIC ACTION POTENTIALS.
- -P159- Effects of Sodium and Calcium Channel Blockers on Monophasic Action Potential(MAP)Recordings Assessed by the Canine Isolated, Blood-Perfused Ventricular Tissue Preparation(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATIO
- -P157- Electrophysiological and Pharmacological Characteristics of Digitalis-induced Triggered Activity in the Canine Isolated, Blood-perfused Ventricular Muscle Preparation.(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SO
- Effect of the Sarcolemmal K_ Channel Blocker HMR1098 on Arrhythmias Induced by Programmed Electrical Stimulation in Canine Old Myocardial Infarction Model : Comparison With Glibenclamide
- KB-R7943, a Na^+/Ca^ Exchange Inhibitor, Does Not Suppress Ischemai/Reperfusion Arrhythmias nor Digitalis Arrhythmias in Dogs
- Inhibitory Effects of Pre-ischemic and Post-ischemic Treatment With FR 168888, a Na^+/H^+ Exchange Inhibitor, on Reperfusion-Induced Ventricular Arrhythmias in Anesthetized Rat
- Slowing Na^+ Channel Inactivation Prolongs QT Interval and Aggravates Adrenaline-Induced Arrhythmias
- Comparison of the sensitivity of various in vivo animal models for detecting the drug-induced QT interval prolongation(General toxicology, Test methods (1), Proceedings of the 32nd Annual Meeting)
- A Red Wine Vinegar Beverage can Inhibit the Renin-Angiotensin System : Experimental Evidence in Vivo(Pharmacology)
- The Endothelium-Dependent Vasodilator Action of a New Beverage Made of Red Wine Vinegar and Grape Juice(Pharmacology)
- Dangerous QT Prolongation Can be Assayed with Two Types of In Vivo Models ; Halothane-Anesthetized Dog and Chronic Atrioventricular Block Dog(Cardiovascular Pharmacology, Basic/Clinical 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation
- The Antipsychotic and Antiemetic Drug Prochlorperazine Delays the Ventricular Repolarization of the In Situ Canine Heart
- Electropharmacological Effects of a Spironolactone Derivative, Potassium Canrenoate, Assessed in the Halothane-Anesthetized Canine Model
- Cardiovascular Effects of an L/N-type Ca^ Channel Blocker Cilnidipine Assessed in the Chronic Atrioventricular Conduction Block Dogs
- PE-353 Mexiletine Decreased the Ventricular Electrical Vulnerability in the Canine Model of Sparfloxacin-Induced Long QT Syndrome(Cardiovascular Pharmacology, Basic/Clinical 3 (H) : PE60)(Poster Session (English))
- OE-275 A Spironolactone Derivative, Potassium Canrenoate, Prolongs the QT Interval but Shortens the Electrically Vulnerable Period of In Vivo Canine Hearts(Cardiovascular Pharmacology, Basic/Clinical 1 (H) : OE34)(Oral Presentation (English))
- The QT-Prolonging Effects of a Histamine H1 Receptor Antagonist Terfenadine Assessed in the In Vivo Canine Heart Model: Comparison of the Rate-Correcting Methods for the Ventricular Repolarization Periods
- Relationship Between Phosphodiesterase Inhibition Induced by Several Kampo Medicines and Smooth Muscle Relaxation of Gastrointestinal Tract Tissues of Rats
- N- Plus L-Type Ca^ Channel Blocker Cilnidipine Decreased the Proarrhythmic Potential of the Canine Sudden Cardiac Death Model
- Effects of Clinically Available Blended Herbal Medicines (Kampo Extracts) on the Phosphodiesterase Activity in Rat Hearts
- Cardiovascular and Adenylate Cyclase Stimulating Effects of Colforsin Daropate, a Water-Soluble Forskolin Derivative, Compared With Those of Isoproterenol, Dopamine and Dobutamine
- Effects of Disopyramide and Mexiletine on the Terminal Repolarization Process of the In Situ Heart Assessed Using the Halothane-Anesthetized In Vivo Canine Model
- Comparison of the In Vivo Electrophysiological and Proarrhythmic Effects of Amiodarone With Those of a Selective Class III Drug, Sematilide, Using a Canine Chronic Atrioventricular Block Model
- Effects of a Novel Vesamicol Receptor Ligand, m-(Iodobenzyl)trozamicol, on the Canine Isolated, Blood-Perfused Atrioventricular Node Preparation
- -0933- Measurement of Adenylyl Cyclase Activity in the Contractile and Conductive Elements of the Canine Heart : Comparison of the Regional Adenylyl Cyclase Activity after the Treatment by Purinergic or Cholinergic Agonists.(PROCEEDINGS OF THE 59th ANNUAL
- Measurements of Cardiac Ion Channel Subunits in the Chronic Atrioventricular Block Dog
- Development of a Halothane-Adrenaline Arrhythmia Model Using In Vivo Guinea Pigs
- In Vitro and ex Vivo Ca-Antagonistic Effect of 2-Methoxyethyl (E)-3-phenyl-2-propen-1-yl (±)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl) pyridine-3,5-dicarboxylate (FRC-8653), a New Dihydropyridine Derivative
- Effect of High Glucose Concentration on Mitochondrial Metabolism in Neuronal Cells
- 一次救命のための新たな携帯型人工呼吸器の開発
- Quantitative Analysis of the Antiarrhythmic Effect of Drugs on Canine Ventricular Arrhythmias by the Determination of Minimum Effective Plasma Concentrations : Pharmacology and Clinical Evaluation of Antiarrhythmic Drugs
- PERIPHERAL EFFECTS OF GUANFACINE COMPARED TO THOSE OF CLONIDINE THE DOG
- Cardiovascular Effects of Orally Administered HNS-32, an Originally Synthesized Azulene-1-carboxamidine Derivative, Assessed in the In Vivo Rat Model
- Pharmacological and Electrophysiological Characterization of Junctional Rhythm During Radiofrequency Catheter Ablation of the Atrioventricular Node : Possible Involvement of Neurotransmitters From Autonomic Nervous System
- Electrophysiological, Anatomical and Histological Remodeling of the Heart to AV Block Enhances Susceptibility to Arrhythmogenic Effects of QT-Prolonging Drugs
- Molecular Mechanisms of Cardiostimulatory Effects of Sildenafil
- Effects of Sildenafil (Viagra TM) on the Cyclic AMP Hydrolyzing Phosphodiesterase Activity in the Canine Heart Assessed Using a Modified Enzymatic Fluorometric Assay Technique
- Effects of ONO : 2235, an Aldose Reductase Inhibitor, on Muscarinic Receptors and Contractile Response of the Urinary Bladder in Rats with Streptozotocin : Induced Diabetes
- Physical and Pharmacological Regulation of Atrial Natriuretic Peptide Release from the Isolated, Blood-Perfused Right Atrium of the Dog
- Neuronal Ca^ Channel Blocking Action of an Antihypertensive Drug, Cilnidipine, in IMR-32 Human Neuroblastoma Cells
- Effects of L/N-Type Calcium Channel Antagonist, Cilnidipine on Progressive Renal Injuries in Dahl Salt-Sensitive Rats(Pharmacology)
- Neuroprotective Effects of a Dual L/N-type Ca^ Channel Blocker Cilnidipine in the Rat Focal Brain Ischemia Model(Pharmacology)
- Suppression of Formalin-Induced Nociception by Cilnidipine, a Voltage-Dependent Calcium Channel Blocker
- Clinical Study of Delapril Hydrochloride in Patients with Acute Myocardial Infarction: Effects of Early ACE Inhibition foflowing Effective Thrombofytic Coronary Recanalizati
- Enzymatic Fluorometric Assay for Adenylyl Cyclase Activity Comparison with Radioimmunoassay and Original [alpha-32P] ATP Salomon Method
- Effects of Mexiletine on the Canine Cardiovascular System Complicating Cisapride Overdose: Potential Utility of Mexiletine for the Treatment of Drug-Induced Long QT Syndrome
- Effect of Magnesium Sulfate on the Haloperidol-Induced QT Prolongation Assessed in the Canine In Vivo Model Under the Monitoring of Monophasic Action Potential
- Effects of a Class III Antiarrhythmic Drug, Dofetilide, on the In Situ Canine Heart Assessed by the Simultaneous Monitoring of Hemodynamic and Electrophysiological Parameters
- Role of Circulating Catecholamines in Reflex Tachycardia Induced by Ca Antagonists
- Cardiac Effects of Clinically Available Kampo Medicine Assessed With Canine Isolated, Blood-Perfused Heart Preparations
- Cardiac Ca^ Channel-Blocking Effects of the Cyproheptadine Derivative AH-1058 in Isolated Guinea Pig Cardiomyocytes
- 1050 INHIBITORY EFFECTS OF CILNIDIPINE, A DHP CALCIUM ANTAGONIST, ON NOREPINEPHRINE RELEASE AND N-TYPE CALCIUM CURRENTS
- EFFECTS OF PROSTAGLANDINS ON LATE CORONARY LIGATION ARRHYTHMIAS IN THE DOG
- Famotidine neither affects action potential parameters nor inhibits human ether-a-go-go-related gene (hERG) K^+ current
- Characterization of the Halothane-Anesthetized Guinea-Pig Heart as a Model to Detect the K^+ Channel Blocker-Induced QT-Interval Prolongation(Pharmacology)
- PJ-719 Beat-to-beat Variability of Ventricular Repolarization Period Can Predict Onset of Acquired Long QT Syndrome(Arrhythmia, basic-6 (A) PJ121,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-345 Long-term Blockade of N-type Ca^ Channels Reversed the Ventricular Electrical Remodeling in the Canine Model of Long QT Syndrome(Cardiovascular pharmacology, basic/clinical-4 (H) PJ58,Poster Session (Japanese),The 70th Anniversary Annual Scient
- Halothane Sensitizes the Guinea-Pig Heart to Pharmacological I_ Blockade : Comparison With Urethane Anesthesia
- A Simple In Vivo Atrial Fibrillation Model of Rat Induced by Transesophageal Atrial Burst Pacing
- ON THE HISTAMINE RECEPTOR OF THE CANINE MYOCARDIUM AND CORONARY VASCULATURE
- Cardiac Effects of Salvia Miltiorrhiza/Dalbergia Odorifera Mixture, an Intravenously Applicable Chinese Medicine Widely Used for Patients With Ischemic Heart Disease in China
- Effect of New Type β-blocker, Tilisolol Hydrochloride,on the Cardiovascular System in Healthy Young Volunteers
- P8-24 Time-course of cardiovascular adaptation in the complete atrioventricular conduction block model(CIRCULATORY SYSTEM-2/ACTIVE OXYGEN)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Cardiovascular Effects of L-158,809, a New Angiotensin Type 1 Receptor Antagonist, Assessed Using the Halothane-Anesthetized In Vivo Canine Model
- Utilization of Telemetry System to Assess the Cardiovascular Profile of AH-1058, a New Cardioselective Ca^ Channel Blocker, in Conscious Dogs
- Electrophysiological and Cardiohemodynamic Effects of AH-1058, a New Type Calcium Channel Blocker, Assessed by the In Vivo Canine Model
- Cilnidipine Attenuates Renal Nerve Stimulation-Induced Renal Vasoconstriction and Antinatriuresis in Anesthetized Dogs