Cilnidipine Attenuates Renal Nerve Stimulation-Induced Renal Vasoconstriction and Antinatriuresis in Anesthetized Dogs
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概要
- 論文の詳細を見る
We examined the effects of cilnidipine, which is an L and N-type Ca<SUP>2+</SUP> channel blocker, on adrenergically regulated renal functions in anesthetized dogs. Renal nerve stimulation (RNS) at high frequency (3-7 Hz) decreased renal blood flow (RBF) without changes in systemic blood pressure. The RBF response was inhibited by intrarenal arterial (i.r.a.) infusion of cilnidipine at 0.1-0.3 μg/kg/min. Lowfrequency RNS (0.5 -1 Hz) reduced absolute and fractional urinary sodium excretion. These responses were attenuated during i.r.a. infusion of cilnidipine at 0.3 μg/kg/min. An increase in norepinephrine secretion rate induced by low-frequency RNS was also attenuated during cilnidipine infusion. These results suggest that cilnidipine can suppress norepinephrine release from the renal nerve endings and thereby interfere with the neural control of renal functions.
- 社団法人 日本薬理学会の論文
- 1997-09-01
著者
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DOHMOTO Hideki
Pharmaceutical Research Laboratories, Ajinomoto Co., Inc.
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YOSHIMOTO Ryota
Pharmaceutical Research Laboratories, Ajinomoto Co., Inc.
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Satoh Susumu
Department Of Pharmacology Pharmaceutical Institute Tohoku University
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Hisa Hiroaki
Department Of Pharmacology Pharmaceutical Institute Tohoku University
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Dohmoto Hideki
Pharmaceutical Research Laboratories Pharmaceuticals Company Ajinomoto Co. Inc.
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Dohmoto Hideki
Life Science Laboratories Central Research Laboratories Ajinomoto Co. Inc.:pharmaceuticals Research
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Satoh Susumu
Department Of Neurosurgery Yamagata Prefectural Central Hospital
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Yoshimoto Ryota
Pharmaceutical Research Laboratories Pharmaceuticals Company Ajinomoto Co. Inc.
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YOSHIMOTO Ryota
Life Science Laboratories, Central Research Laboratories, Ajinomoto Co., Inc.
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Takahara Akira
Life Science Laboratories, Central Research Laboratories, Ajinomoto Co., Inc.
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Aikawa Tokiko
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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