HYPOTENSIVE EFFECT OF CAPTOPRIL IN RELATION TO PLASMA RENIN ACTIVITY IN ANESTHETIZED RATS
スポンサーリンク
概要
- 論文の詳細を見る
The effect of captopril (D-3-mercapto-2-methylpropanoyl-L-proline), a converting enzyme inhibitor, on the systemic blood pressure in pentobarbital anesthetized rats was investigated. Experiments were performed in four groups of rats : untreated, Na-restricted, furosemide treated and bilaterally nephrectomized, respectively. Intravenous injection of 1 mg/kg of captopril caused a significant hypotensive effect in the three groups of rats but not in the nephrectomized group. Individual values for the hypotensive effect produced by captopril and plasma renin activity obtained just before injection of captopril showed a highly significant correlation.
- 公益社団法人日本薬学会の論文
著者
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SATOH Hiroko
Department of Chemistry, Gunma University
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Suzuki Mizue
Department Of Environmental Biochemistry Shizuoka College Of Pharmacy
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Suzuki Mizue
Department Of Pharmacology Pharmaceutical Institute Tohoku University
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Satoh Susumu
Department Of Neurosurgery Yamagata Prefectural Central Hospital
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Satoh Hiroko
Department Of Pharmacology Pharmaceutical Institute Tohoku University
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Satoh Hiroko
Department Of Chemistry Gunma University
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SATOH Hiroko
Department of Biochemical Toxicology, School of. Pharmaceutical Sciences, Showa University
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